Role of Fiberoptic Bronchoscopy in Decision‐Making in the Management of Post‐Hematopoietic Stem Cell Transplant Patients Presenting with Pulmonary Infiltrates: A Retrospective Cohort Study
Rattachement africain : sa, Égypte. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: The role of fiberoptic bronchoscopy (FOB) in the management of patients presenting with pulmonary infiltrates after hematopoietic stem cell transplant (HSCT) remains unclear. We aimed to evaluate the diagnostic value and safety of FOB at our center. METHODS: This retrospective study included all patients with post-HSCT pulmonary infiltrates who underwent FOB between 2016 and 2019. The demographic, clinical, interventional, microbiological, and histological data and changes in management and the 6-month outcome were recorded. RESULTS: A total of 86 consecutive HSCT recipients were included. The median patient age was 34 years (range: 14-67), 53 patients (61.6%) were males. The median interval between symptom onset and FOB was 7 days (IQR: 2-17). FOB yielded a positive result in 53 patients (61.6%). The pathogen was a virus, bacteria, fungus in 29 (33.7%), 19 (22.1%), and 11 (12.8%) patients, respectively. The treatment was modified in 52 patients (60.5%) according to the FOB result. An imaging finding of "tree-in-bud" was associated with a positive FOB yield (p = 0.05). The timing of bronchoscopy (<4 vs. ≥5 days), graft-versus-host disease, neutropenia, and antimicrobial use had no significant effect (p > 0.05). No serious complications were encountered. CONCLUSION: FOB led to changes in management in over half of the patients. Delay up to 1 week after presentation and empirical antimicrobials did not have any effect on the yield. FOB is a safe diagnostic tool in the post-HSCT patients with pulmonary infiltrates.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Role of Fiberoptic Bronchoscopy in Decision‐Making in the Management of Post‐Hematopoietic Stem Cell Transplant Patients Presenting with Pulmonary Infiltrates: A Retrospective Cohort Study
- Date Crossref
- 18/01/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Alfaisal University pays non établi dans la noticeUniversité ou école supérieure
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King Faisal Specialist Hospital & Research Centre pays non établi dans la noticeÉtablissement de santé
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National Water Research Center Égypte (code pays fourni par la source)Structure de recherche
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King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia pays non établi dans la noticeStructure de recherche
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National Research Center Cairo Egypt National Research Center Cairo Egypt, Égypte (pays nommé en fin d’affiliation)Structure de recherche
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King Faisal Specialist Hospital and Research Center Madinah Saudi Arabia pays non établi dans la noticeStructure de recherche
Alfaisal University, King Faisal Specialist Hospital & Research Centre et National Water Research Center (Égypte), avec 3 autres affiliations. Pays d’affiliation : Égypte.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.