Accès ouvert déclaré
2025
article
The impact of a tailored nutrition intervention delivered for the duration of hospitalisation on daily energy delivery for patients with critical illness (INTENT): a phase II randomised controlled trial
Emma J. Ridley, Michael Bailey, Marianne J. Chapman, Lee‐anne S. Chapple, Adam M. Deane, Marlene Gojanovic, Alisa M. Higgins, Carol Hodgson, Victoria King, Andrea P. Marshall, Eliza G. Miller, Shay McGuinness, Rachael Parke, Eldho Paul, Andrew Udy, Farisha Ali, Rebecca Baskett, Magdalena Butler, Keri-Anne Cowdrey, Eileen Gilder, Lex Gillan, Su-Zahn Koorts, Brittany L. Mason, Ellie McMahon, Karina O’Connor, Melissa Robertson, Samantha Ryan, Anna Small, Andrew Xia, Megan Berner, Christine Choong, Glenn M. Eastwood, Kate Hamilton, Daryl Jones, Leah Peck, Helen Young, Lauren Ballantyne, Catherine Boschert, Cameron Knott, Bridget Roberts, Julie Smith, Zoe Flick, Kalpesh Gandhi, Barbara Hannah, Yvonne Li, Kiran Nand, Treena Sara, Sylvia Wei, Lina Briek, Graeme Duke, Kym Gellie, Stephanie Hunter, Nicole Robertson, Jonathan Barrett, Brydie Cleeve, Caroline Guille, Gabrielle Hanlon, Sarah Jelly-Butterworth, Julie O’Donnell, Carmel Zoanetti, Zhoe Coram, Karen Edis, Mike Gomez, Alice Goodman, Kavi Haji, Jenny Moss, Jodie Prendergast, Janet C. L. Tam, Ravindranath Tiruvoipati, Fiona Turnbull, Julie Cussen, Maimoonbe Gough, Sarah L. Lovelock, Lisa Mahoney, David Pearson, Mandy Tallott, Emily Ainslie, Kate Flynn, Kerri Gordon, Tim Stewart, Larissa Telfer, Victoria Williams, Vishwanath Biradar, Hanaa Chahine, Edda Jessen, Matia Kapsambelis, Melissa Lydyard, Ashlee Martin, Julie Puccini, Natalie Soar, Leah Sommerfield, Bronwyn Bartholomew, Peter Collins, Claire Filet, Mackenzie Finnis, Chloe Jobber, Katherine Jongebloed, I. Anne Leditschke, Kimberley Browning, Jennifer Chang, Dinu Girijadevi, Areege Hussein, Vivian Lai, Rima Song, Tony Williams, Oshara de Silva, Ashlee Gervasoni, Carolyn Hall, Lauren Hanna, Sheree Phillips, Yahya Shehabi, Rebecca Gresham, Matin Jamei, Sheeja Joy, Julie Lowrey, Kristy Masters, Ian Seppelt, Wendy Tu, Christina Whitehead, Tina Aboltins, Hayley Collins, Rachael A Evans, Angaj Ghosh, Simone Said, Vivian Tsang, Lynette M. De Groot, Ra’eesa Doola, Meg Harward, Cassie Jones, Josephine Mackay, Jason Meyer, Tahnie G. Takefala, James Walsham, Stuart Baker, Anthony Khoo, Shannon Lewis, Nissen Aj, Alexis Tabah, Alicia Wiese, Lewis Campbell, Mei Chin, Rebecca Garcia, Kirsty Smyth, Annabel Thallon, Emma Bidgood, Jessica L. Browne, Kathleen Byrne, Kate Fetterplace, Hilda Griffin, Sarah Phillips, Kym Wittholz, Jasmin Board, Peta Bretag, Aidan Burrell, Adam F. Cunningham, Dashiell Gantner, Ramez Hanna, Kate Lambell, Karina Lay, Elisa Licari, Lee Lin Loh, Emma Martin, Phoebe McCracken, J Obeid, Caitlin Rabel, Peter Thanhauser, Chloe Vadiveloo, Cyndi Wong, Meredith Young, Cameron French, Greta Hollis, Adrian Powlesland, Kiran Shekar, MC Vasudevan, Emma Whitmore, Tennealle Direen, Martine Hatzi, Cathy Kurenda, Sandra Peake, A. R. Thatcher, Patricia Williams, Michelle Horton, Nima Kakho, Matthew J. Maiden, Tania Salerno, Jemma Trickey
22Citations signalées — pas une note de qualité
31Institutions déclarées
2Pays d’affiliation déclarés
Résumé fourni par la source
BACKGROUND: Nutrition interventions commenced in ICU and continued through to hospital discharge have not been definitively tested in critical care to date. To commence a program of research, we aimed to determine if a tailored nutrition intervention delivered for the duration of hospitalisation delivers more energy than usual care to patients initially admitted to the Intensive Care Unit (ICU). METHODS: A multicentre, unblinded, parallel-group, phase II trial was conducted in twenty-two hospitals in Australia and New Zealand. Adult patients, requiring invasive mechanical ventilation (MV) for 72-120 h within ICU, and receiving < 80% estimated energy requirements from enteral nutrition (EN) were included. The intervention (tailored nutrition) commenced in ICU and included EN and supplemental parenteral nutrition (PN), and EN, PN, and/or oral nutrition after liberation from MV, and was continued until hospital discharge or study day 28. The primary outcome was daily energy delivery from nutrition (kcal). Secondary outcomes included duration of hospital stay, ventilator free days at day 28 and total blood stream infection rate. MAIN RESULTS: The modified intention to treat analysis included 237 patients (n = 119 intervention and n = 118 usual care). Baseline characteristics were balanced; the median [interquartile range] intervention period was 19 [14-35] and 19 [13-32] days in the tailored nutrition and usual care groups respectively. Energy delivery was 1796 ± 31 kcal/day (tailored nutrition) versus 1482 ± 32 kcal/day (usual care)-adjusted mean difference 271 kcal/day, 95% CI 189-354 kcal. No differences were observed in any secondary outcomes. CONCLUSIONS: A tailored nutrition intervention commenced in the ICU and continued until hospital discharge achieved a significant increase in energy delivery over the duration of hospitalisation for patients initially admitted to the ICU. Trial registration ClinicalTrials.gov Identifier NCT03292237 . First registered 25th September 2017. Last updated 10th Feb 2023.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The impact of a tailored nutrition intervention delivered for the duration of hospitalisation on daily energy delivery for patients with critical illness (INTENT): a phase II randomised controlled trial
- Date Crossref
- 06/01/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Clinical Nutrition and GastroenterologyNutrition and Health in AgingRespiratory Support and Mechanisms