Associations of treatment with hypnotics with suicide and attempted suicide: A nationwide cohort study
Rattachement africain : dk, gb, us, au. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Hypnotics have been linked to suicidal behaviors. While existing evidence has established findings of associations, more knowledge is needed regarding benzodiazepine (BZD) and non-benzodiazepine (n-BZD) hypnotics. AIM: To examine whether individuals in treatment with hypnotics had higher rates of suicide and suicide attempts than those not in treatment. METHODS: A longitudinal nationwide cohort design was applied to individual-level register data, including all individuals aged 15+ years who lived in Denmark from 1995 to 2021. Incidence rate ratios (IRR) for suicide and suicide attempts were estimated using Poisson regression models. Using the National Prescription Registry, individuals who redeemed prescriptions for hypnotics at pharmacies were identified. Death by suicide was identified in the Cause of Death Register. RESULTS: A total of 7,311,630 individuals were observed over 122,681,369 person-years. In all, 678 males and 553 females died by suicide while in treatment with BZD, resulting in respective adjusted IRRs of 2.1 (95% CI: 1.9-2.4) and 2.6 (95% CI: 2.3-3.0), when compared to those not in treatment. A total of 1774 males and 1212 females died by suicide while in treatment with n-BZD and the adjusted IRRs were 3.4 (95% CI: 3.1-3.7) and 3.6 (95% CI: 3.4-3.9), respectively. CONCLUSIONS: While confounding by indication is likely to be a major contributor, the fact that individuals in treatment with BZD or n-BZDs had higher rates of suicide and suicide attempts when compared to those not in treatment emphasizes the need to carefully monitor their mental state.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Associations of treatment with hypnotics with suicide and attempted suicide: A nationwide cohort study
- Date Crossref
- 02/01/2025
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Copenhagen University Hospital Copenhagen Research Center for Mental Health – CORE pays non établi dans la noticeÉtablissement de santé
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Danish National Centre for Social Research pays non établi dans la noticeStructure de recherche
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Danish Research Institute for Suicide Prevention pays non établi dans la noticeOrganisation à but non lucratif
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University of Edinburgh Center for Clinical Brain Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of Copenhagen pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins University Department of Psychiatry and Behavioral Sciences pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins Medicine pays non établi dans la noticeÉtablissement de santé
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University of Oxford Center for Suicide Research pays non établi dans la noticeUniversité ou école supérieure
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Australian National University pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Health and Medical Sciences Section of Epidemiology pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins Bloomberg School of Public Health Department of Mental Health pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins Center on Aging and Health pays non établi dans la noticeInstitution
Copenhagen Research Center for Mental Health – CORE — Copenhagen University Hospital, Danish National Centre for Social Research et Danish Research Institute for Suicide Prevention, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.