Impact of COVID-19, lockdowns and vaccination on immune responses in a HIV cohort in the Netherlands
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Le résumé fourni par la source
Introduction: During the COVID-19 pandemic, major events with immune-modulating effects at population-level included COVID-19 infection, lockdowns, and mass vaccinations campaigns. As immune responses influence many immune-mediated diseases, population scale immunological changes may have broad consequences. Methods: We investigated the impact of lockdowns, COVID-19 infection and vaccinations on immune responses in the 2000HIV study including 1895 asymptomatic virally-suppressed people living with HIV recruited between October 2019 and October 2021. Their inflammatory profile was assessed by targeted plasma proteomics, immune responsiveness by cytokine production capacity of circulating immune cells, and epigenetic profile by genome-wide DNA methylation of immune cells. Results: Past mild COVID-19 infection had limited long-term immune effects. In contrast, COVID-19 vaccines and especially lockdowns significantly altered both the epigenetic profile in immune cells at DNA methylation level and immune responses. Lockdowns resulted in a strong overall exaggerated immune responsiveness, while COVID-19 vaccines moderately dampened immune responses. Lockdown-associated immune responsiveness alterations were confirmed in 30 healthy volunteers from the 200FG cohort that, like the 2000HIV study, is part of the Human Functional Genomics Project. Discussion: Our data suggest that lockdowns have unforeseen immunological effects. Furthermore, COVID-19 vaccines have immunological effects beyond anti-SARS-CoV-2 activity, and studies of their impact on non-COVID-19 immune-mediated pathology are warranted.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Impact of COVID-19, lockdowns and vaccination on immune responses in a HIV cohort in the Netherlands
- Date Crossref
- 18/12/2024
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Radboud University Nijmegen Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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Radboud University Medical Center Department of Internal Medicine and Radboud Center for Infectious Diseases pays non établi dans la noticeOrganisme public
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Elisabeth-TweeSteden Ziekenhuis pays non établi dans la noticeÉtablissement de santé
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Medizinische Hochschule Hannover pays non établi dans la noticeUniversité ou école supérieure
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Helmholtz Centre for Infection Research pays non établi dans la noticeStructure de recherche
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Centre for Individualised Infection Medicine pays non établi dans la noticeStructure de recherche
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Center for Experimental and Clinical Infection Research pays non établi dans la noticeStructure de recherche
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Erasmus MC pays non établi dans la noticeÉtablissement de santé
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Erasmus University Rotterdam Department of Internal Medicine and Department of Medical Microbiology and Infectious diseases pays non établi dans la noticeUniversité ou école supérieure
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OLVG pays non établi dans la noticeÉtablissement de santé
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Nijmegen Institute for Scientist Practitioners in Addiction pays non établi dans la noticeInstitution
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Donders Institute for Brain pays non établi dans la noticeStructure de recherche
Department of Psychiatry — Radboud University Nijmegen, Department of Internal Medicine and Radboud Center for Infectious Diseases — Radboud University Medical Center et Elisabeth-TweeSteden Ziekenhuis, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.