Jan van Lunzen

Dolutegravir plus lamivudine downregulates cellular stress responses vs. three-drug HIV regimens

Victoria Rios-Vazquez, Wilhelm A. J. W. Vos, Marc J. T. Blaauw, Louise E. van Eekeren et autres

OBJECTIVE: To compare the systemic and immune effects of two-drug regimens (2DR) and three-drug regimens (3DR) in people with HIV (PWH). DESIGN: In a cross-sectional study, multiomics data were analyzed in dolutegravir (DTG) plus lamivudine (3TC) 2DR and 3DR comprising DTG with …

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Distinct metabolic perturbations link liver steatosis and incident CVD in lean but not obese PWH

Louise E. van Eekeren, Nadira Vadaq, Marc J. T. Blaauw, Albert L. Groenendijk et autres

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a key risk factor for cardiovascular disease (CVD), potentially driven by shared metabolic mechanisms. Metabolic perturbations associated with MASLD and CVD remain underexplored in people with HIV (PWH). METHODS: We used data from the …

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Persistent Viral Control Status is Associated with Enhanced Innate Immune Responses in People Living with Hiv-1

Jéssica Cristina dos Santos, Albert L. Groenendijk, Suzanne D. E. Ruijten, Rainer Knoll et autres

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Impact of COVID-19, lockdowns and vaccination on immune responses in a HIV cohort in the Netherlands

Twan Otten, Xun Jiang, Manoj Kumar Gupta, Nadira Vadaq et autres

Introduction: During the COVID-19 pandemic, major events with immune-modulating effects at population-level included COVID-19 infection, lockdowns, and mass vaccinations campaigns. As immune responses influence many immune-mediated diseases, population scale immunological changes may have broad consequences. Methods: We investigated the impact of lockdowns, …

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Plasma proteomic signatures of liver steatosis and fibrosis in people living with HIV: a cross-sectional study

Louise E. van Eekeren, Quirijn de Mast, Elise M. G. Meeder, Adriana Navas et autres

Background Insights into the mechanisms driving metabolic dysfunction-associated steatotic liver disease (MASLD) in people living with HIV (PLHIV) remain limited. Plasma proteomics holds promise for biomarker discovery and the elucidation of biological mechanisms. Methods We performed cross-sectional analyses on data from 1036 …

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Mental health and its consequences in people living with HIV: A network approach

Elise M. G. Meeder, Louise E. van Eekeren, Marc J. T. Blaauw, Albert L. Groenendijk et autres

OBJECTIVES: Psychiatric symptoms occur frequently in people living with human immunodeficiency virus (PLWH), which may affect quality of life, sexual risk behavior, and adherence to antiretroviral therapy (ART). Data from large cohorts are limited, and symptoms are often analyzed in isolation. Therefore, …

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Risk of Non–AIDS–Defining Events Is Lower in Antiretroviral Therapy (ART)–Naive HIV Controllers Than in Normal Progressors on Suppressive ART

Albert L. Groenendijk, Pedro Miranda Afonso, Ferdinand W N M Wit, Louise E. van Eekeren et autres

BACKGROUND: We aimed to compare the non-AIDS event (nADE) risk between normal progressors using antiretroviral therapy (NP-ART) and people with human immunodeficiency virus (HIV, PWH) who naturally control HIV infection (HIV controllers), as well as the risk of nADE following ART in …

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Dynamics of virological and immunological markers of HIV persistence after allogeneic haematopoietic stem-cell transplantation in the IciStem cohort: a prospective observational cohort study

María Salgado, Cristina Gálvez, Monique Nijhuis, Mi Kwon et autres

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HIV immunological non-responders are characterized by extensive immunosenescence and impaired lymphocyte cytokine production capacity

Wilhelm A. J. W. Vos, Adriana Navas, Elise M. G. Meeder, Marc J. T. Blaauw et autres

Introduction Immunological non-responders (INR) are people living with HIV (PLHIV) who fail to fully restore CD4+ T-cell counts despite complete viral suppression with antiretroviral therapy (ART). INR are at higher risk for non-HIV related morbidity and mortality. Previous research suggest persistent qualitative …

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Liver Steatosis is Prevalent in Lean People With HIV and Associated With Exposure to Antiretroviral Treatment—A Cross-sectional Study

Louise E. van Eekeren, Nadira Vadaq, Wilhelm A. J. W. Vos, Marc J. T. Blaauw et autres

Abstract Background Steatotic liver disease is suggested to have a higher prevalence and severity in people with HIV (PHIV), including in those with a normal body mass index (BMI). In this study, we used data from the 2000HIV cohort to (1) assess …

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Cardiometabolic Differences in People Living with HIV Receiving Integrase Strand Transfer Inhibitors Compared to Non-nucleoside Reverse Transcriptase Inhibitors: Implications for Current ART Strategies

Wilhelm A. J. W. Vos, Nadira Vadaq, Vasiliki Matzaraki, Twan Otten et autres

In people living with HIV (PLHIV), integrase strand transfer inhibitors (INSTIs) are part of the first-line combination antiretroviral therapy (cART), while non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens are alternatives. Distinct cART regimens may variably influence the risk for non-AIDS comorbidities. We aimed …

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Psychiatric symptoms in people living with HIV: prevalences, interactions and consequences

Elise M. G. Meeder, Marc J. T. Blaauw, Louise E. van Eekeren, Albert L. Groenendijk et autres

Introduction People living with HIV (PLHIV) experience higher levels of mental health issues compared to the general population. Especially depression, anxiety, impulsivity and substance use occur frequently in PLHIV. This is thought to have important consequences for quality of life, sexual risk …

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