Cross-Vendor Multiparametric Mapping of the Human Brain Using 3D-QALAS: A Multicenter & Multivendor Study

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Motivation: To address the unmet need for a cross-vendor, multiparametric technique to facilitate data pooling across sites. Goal(s): To evaluate a vendor-standardized multiparametric mapping scheme based on 3D-QALAS for whole-brain T1, T2, and proton density (PD) mapping. Approach: Intra-scanner repeatability and inter-vendor reproducibility were evaluated in vivo on five different 3T systems from four vendors (GE, Philips, Siemens, and Canon). Patients with multiple sclerosis were scanned on systems from different vendors to assess the feasibility of the scheme in real-world clinical settings. Results: 3D-QALAS provided T1, T2, and PD with coefficient of variations <4.0% using 3T scanners from different manufacturers. Impact: The four major vendors used in this study constitute a considerable portion of the global installation base, demonstrating the value of cross-vendor quantitative technique 3D-QALAS for imaging in clinical sites with multiple vendors, as well as in multicenter research settings.

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