Assessment of PAX1 and JAM3 methylation triage efficacy across HPV genotypes and age groups in high-risk HPV-positive women in China
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Le résumé fourni par la source
Objective: methylation (CISCER) test in triaging high-risk human papillomavirus (hrHPV)-positive women. Methods: We enrolled women who underwent opportunistic screening at Cervical Disease outpatient clinics of Xuzhou Maternity and Child Health Hospital, and Yueyang Central Hospital from December 2022 to May 2024. The effectiveness of CISCER and cytology tests in triaging hrHPV+ patients was analyzed. Results: Among the 436 study participants, 283 (64.9%) had no cervical intraepithelial neoplasia (CIN), while 53 (12.2%) had CIN1, 40 (9.2%) had CIN2, 34 (7.8%) had CIN3, and 26 (5.9%) had cervical cancers. The CISCER tests identified all cases of cervical cancer, particularly 2 hrHPV-negative adenocarcinoma cases. In 396 hrHPV+ individuals, the sensitivity of CISCER tests for detecting CIN2+ lesions was 92.6% (95% CI: 87.2-97.9%), with a specificity of 95.7% (95% CI: 93.4-98%), and an area under the receiver operating characteristic curve (AUC) of 0.941 (95% CI: 0.903-0.979), outperforming cytology tests in both HPV16/18+ and non-16/18 hrHPV+ women. Notably, CISCER demonstrated 100% (95% CI: 90-100%) sensitivity in women aged≥50 and 100% (95%CI: 93.6-100%) specificity in women aged<30. Among CIN2+ women, 37.2% (including 3 cancer) showed low-grade cytological changes that could be detected by CISCER. Meanwhile, 52% of CIN2- women exhibited cytological abnormalities but had negative CISCER results. The immediate CIN3+ risk based on positive CISCER results was 54% (95% CI: 43.8-63.9%). Conclusion: methylation detection using cervical exfoliated cells showed superior triage performance for hrHPV-positive patients compared to traditional strategies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Assessment of PAX1 and JAM3 methylation triage efficacy across HPV genotypes and age groups in high-risk HPV-positive women in China
- Date Crossref
- 26/11/2024
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Maternal and Child Health Hospital of Xuzhou pays non établi dans la noticeÉtablissement de santé
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Shanghai University of Traditional Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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Yueyang Hospital pays non établi dans la noticeÉtablissement de santé
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OriginWater (China) pays non établi dans la noticeEntreprise
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Hunan Normal University Department of Gynecology pays non établi dans la noticeUniversité ou école supérieure
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Xuzhou Maternity and Child Health Hospital Department of Cervical Disease pays non établi dans la noticeÉtablissement de santé
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Yueyang Central Hospital Department of Gynecology pays non établi dans la noticeÉtablissement de santé
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Department of Medical Laboratory pays non établi dans la noticeStructure de recherche
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Department of Clinical Laboratory pays non établi dans la noticeStructure de recherche
Maternal and Child Health Hospital of Xuzhou, Shanghai University of Traditional Chinese Medicine et Yueyang Hospital, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.