Combined diet and exercise training decreases serum lipids associated with insulin resistance
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVE: Circulating lipids are linked with insulin resistance and increased cardiovascular disease risk. We previously reported that dihydroceramides, a specific type of sphingolipid, are elevated in insulin-resistant individuals; however, little is known regarding whether insulin-sensitizing lifestyle interventions can improve profiles of sphingolipids and other lipid species. METHODS: A total of 21 individuals with obesity participated in a 3-month lifestyle intervention of combined weight loss and exercise training. Insulin sensitivity was assessed by hyperinsulinemic-euglycemic clamps, and serum lipidomics was conducted. RESULTS: peak and insulin sensitivity increased by 12% and 57%, respectively; and total serum triacylglycerol (TAG), diacylglycerol, dihydroceramides, sphingosine-1-phosphate, and sphinganine-1-phosphate were significantly reduced, as were specific species of dihydroceramides (C18:0 and C24:1). Individuals with higher preintervention TAG concentrations had significant decreases in serum lipids, which were not significantly changed in individuals with lower preintervention TAG. CONCLUSIONS: These data show that serum sphingolipid species previously linked to insulin resistance in humans can be reduced with insulin-sensitizing lifestyle interventions. Furthermore, individuals with elevated serum TAG may significantly benefit from lifestyle interventions that increase insulin sensitivity due to a greater decrease in serum lipids related to insulin resistance.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Combined diet and exercise training decreases serum lipids associated with insulin resistance
- Date Crossref
- 26/11/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Colorado Anschutz pays non établi dans la noticeUniversité ou école supérieure
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Colorado State University Department of Health and Exercise Science pays non établi dans la noticeUniversité ou école supérieure
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Eli Lilly (United States) pays non établi dans la noticeEntreprise
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Oregon State University pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine and Diabetes pays non établi dans la noticeUniversité ou école supérieure
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Eli Lilly and Company Indianapolis Indiana USA pays non établi dans la noticeEntreprise
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School of Exercise pays non établi dans la noticeUniversité ou école supérieure
University of Colorado Anschutz, Department of Health and Exercise Science — Colorado State University et Eli Lilly (United States), avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.