Evaluating the Iron Deficiency Anemia in Type-II Diabetic Patients Taking Metformin and its Association with Oxidative Stress
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Le résumé fourni par la source
Introduction: Iron deficiency anemia (IDA) is a prevalent nutritional deficiency worldwide, particularly affecting vulnerable groups with chronic illnesses, such as type 2 diabetes mellitus (T2DM). T2DM, characterized by insulin resistance and hyperglycemia, impacts numerous physiological processes and is linked with increased oxidative stress. Objective: This study aims to examine the prevalence of iron deficiency anemia in T2DM patients taking metformin and to investigate its association with oxidative stress. Methodology: Conducted at Shalamar Hospital, Lahore, this cross-sectional study took place from September 2023 to September 2024 and included 255 patients aged 30–70 years. Exclusion criteria were patients with chronic kidney disease, liver dysfunction, gastrointestinal disorders affecting nutrient absorption, or those taking iron supplements or medications influencing iron metabolism. Results: Among the participants, 40.9% (92 patients) were diagnosed with IDA, with a mean hemoglobin level of 11.5 g/dL. In contrast, 59.1% (133 patients) without IDA had a higher mean hemoglobin of 14.3 g/dL. IDA patients showed significantly elevated malondialdehyde (MDA) levels at 3.8 μmol/L, compared to 2.5 μmol/L in non-IDA patients (p < 0.05), suggesting increased lipid peroxidation. Antioxidant enzyme levels were also lower in the IDA group, with superoxide dismutase (SOD) and glutathione peroxidase (GPx) at 150 U/mL and 80 U/mL, respectively, versus 200 U/mL and 100 U/mL in non-IDA patients. Conclusion: This study concludes that iron deficiency anemia is common among T2DM patients on metformin and is significantly associated with increased oxidative stress
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Evaluating the Iron Deficiency Anemia in Type-II Diabetic Patients Taking Metformin and its Association with Oxidative Stress
- Date Crossref
- 31/12/2024
- Éditeur
- Indus Publishers
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Combined Military Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Services Hospital Department of Gastroenterology and Liver Disease pays non établi dans la noticeÉtablissement de santé
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Jinnah Postgraduate Medical Center pays non établi dans la noticeÉtablissement de santé
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Shalamar Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Gulab Devi Hospital Department of Internal Medicine pays non établi dans la noticeStructure de recherche
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HBS General Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Jinnah Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
Department of Internal Medicine — Combined Military Hospital, Department of Gastroenterology and Liver Disease — Services Hospital et Jinnah Postgraduate Medical Center, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.