Grip-Strength-Lean-Mass Index (GSLMI) as a valuable tool for sarcopenia diagnosis and survival prognosis in cancer patients: a nationwide multicenter cohort study
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Le résumé fourni par la source
OBJECTIVES: To identify whether the Grip-Strength-Lean-Mass Index (GSLMI) can precisely diagnose sarcopenia and predict prognosis for cancer patients in clinical settings. DESIGN: A nationwide multicenter cohort study. SETTING AND PARTICIPANTS: 8,831 inpatients aged 18 years and older, histologically diagnosed with cancer and receiving anti-cancer therapy. MEASUREMENTS: The GSLMI is the ratio of hand grip strength (HGS) divided by lean mass (LM), calculated by the formula: GSLMI = HGS (kg) / LM (kg). Kaplan-Meier curves and Cox models were used to estimate the association between the GSLMI and survival. RESULTS: A total of 3,071 (48.40%) male and 3,274 (51.60%) female patients were enrolled in the study. The prevalence of GLIS-defined sarcopenia was 2,646 (41.70%). The optimal sex-specific thresholds with the best diagnostic performance to identify a low GSLMI were determined to be <0.61 for males and <0.47 for females based on the ROC curves. According to Kaplan-Meier curves, patients with a high GSLMI exhibited better overall survival than those with a low GSLMI (HR = 0.664, 95%CI = 0.604-0.729, log-rank P < 0.001). Multivariable survival analysis revealed that the GSLMI showed an independent association with a lower hazard of death as a continuous variable (HR = 0.70, 95% CI = 0.51-0.96). CONCLUSIONS: The GSLMI may serve as a novel diagnostic tool for identifying sarcopenia and may have prognostic value for cancer patients. Using the GSLMI represents a feasible and promising option for better managing the health of patients with cancer.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Grip-Strength-Lean-Mass Index (GSLMI) as a valuable tool for sarcopenia diagnosis and survival prognosis in cancer patients: a nationwide multicenter cohort study
- Date Crossref
- 01/01/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Army Medical University Department of Clinical Nutrition pays non établi dans la noticeUniversité ou école supérieure
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Daping Hospital pays non établi dans la noticeÉtablissement de santé
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Third People 's Hospital of Chongqing pays non établi dans la noticeÉtablissement de santé
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Zhengzhou University pays non établi dans la noticeUniversité ou école supérieure
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Beijing Shijitan Hospital pays non établi dans la noticeÉtablissement de santé
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Department of Clinical Nutrition pays non établi dans la noticeÉtablissement de santé
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College of Public Health Department of Epidemiology pays non établi dans la noticeUniversité ou école supérieure
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Capital Medical University Department of Gastrointestinal Surgery and Department of Clinical Nutrition pays non établi dans la noticeUniversité ou école supérieure
Department of Clinical Nutrition — Army Medical University, Daping Hospital et Third People 's Hospital of Chongqing, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.