“They Have to Make an Effort Too”: What Decliners Can Teach Us About HIV Cure/Remission-Related Clinical Trials? Results from a French Qualitative Study
Rattachement africain : fr, gb, be. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Only one study to date has focused on people living with HIV (PLWH) who refused to participate in a HIV cure/remission-related clinical trial (HCCT)-"decliners" hereafter-that included analytical treatment interruption (ATI). Exploring why these persons refuse may provide valuable information to ensure more ethical recruitment and support in HCCTs within the bigger picture of improving HIV cure research. The qualitative component of the AMEP-EHVA-T02/ANRS-95052 study, called AMEP-Decliners, documented the experiences of French PLWH who refused to participate in EHVA-T02/ANRS-VRI07, a phase II randomized, placebo-controlled HCCT with ATI. AMEP-Decliners comprised semi-structured individual interviews with six decliners in two HIV care sites in France between September 2022 and March 2023. The interviews documented their expectations regarding HCCTs, reasons for refusal, and perceived factors that might have led them to participate. Audio files were transcribed, and an inductive thematic analysis was performed. Surprisingly, the main reason for refusal was not ATI but the trial monitoring. Besides the frequency of appointments, respondents emphasized the incompatibility with their active life. One underlying reason for refusal was that participating would have meant "break[ing] the carefree attitude about the disease," reflecting the substantial psychological burden associated with participation. Finally, respondents perceived that the trial's clinical team did not sufficiently recognize their "normal life" and the level of commitment required to participate, leading them to call for greater involvement by the team: "they have to make an effort too." Results from decliners' discourses highlighted that two levels of commitment to participation must be considered when developing HCCTs: psychological burden and logistical constraints. We suggest allowing home examinations and flexible appointment times, prioritizing face-to-face invitations in order to address the psychological burden associated with HCCT participation, and explaining the reasons for monitoring constraints when they cannot be alleviated. Further studies are necessary to confirm our results.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- “They Have to Make an Effort Too”: What Decliners Can Teach Us About HIV Cure/Remission-Related Clinical Trials? Results from a French Qualitative Study
- Date Crossref
- 10/01/2024
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
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Inserm pays non établi dans la noticeOrganisme public
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Economic & Social Sciences pays non établi dans la noticeStructure de recherche
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Institut de Recherche pour le Développement pays non établi dans la noticeOrganisme public
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Université Paris-Est Créteil Vaccine Research Institute pays non établi dans la noticeUniversité ou école supérieure
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Institut de Recherche Vaccinale pays non établi dans la noticeStructure de recherche
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Hôpital Albert-Chenevier pays non établi dans la noticeÉtablissement de santé
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Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes pays non établi dans la noticeStructure de recherche
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Centre d'Immunologie et des Maladies Infectieuses pays non établi dans la noticeStructure de recherche
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Université Paris Cité pays non établi dans la noticeUniversité ou école supérieure
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Hôtel-Dieu de Paris pays non établi dans la noticeÉtablissement de santé
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Inserm, Economic & Social Sciences et Institut de Recherche pour le Développement, avec 9 autres affiliations.
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