RETRACTED: Phytochemical screening, HPLC fingerprinting and in vitro assessment of therapeutic potentials of different apricot cultivars against diabetes, Alzheimer's disease and cancer
Rattachement africain : in, sa, bd. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
) cultivars. High-performance liquid chromatography (HPLC) was utilized to determine the concentrations of bioactive compounds across 10 distinct apricot cultivars. Initial phytochemical screening revealed a significant content of secondary metabolites. Subsequently, methanolic extracts from these cultivars were evaluated for their therapeutic potential against several human cancer cell lines, including prostate cancer (PC-3), lung cancer (A-549), breast cancer (MCF-7), cervical cancer (HELA), and kidney cancer (HEK). Notably, the breast cancer cell line MCF-7 showed a pronounced inhibition rate post-treatment with the apricot extracts. Correlation analysis exhibited phenols are highly correlated with flavonoids (r = 0.92), DPPH (r = 0.95), and alpha-amylase (%) inhibition (r = 0.96), and showed a significant correlation with other parameters. Principal Component Analysis (PCA) revealed that PC1 explained 43.31 % of the variance, while PC2 explained 12.88 %, together explaining 80.033 % of the total variance. PC1 was identified as the dominant axis, indicating the primary pattern of variation among the variables. Hierarchical Cluster Analysis (HCA) divided the cultivars into 2 main clusters, with cluster 2 further subdivided into various sub-clusters and sub-sub-clusters. This analysis highlighted distinct genetic similarities and differences among the apricot cultivars. Among the tested cultivars, 'Irani' and 'Tilton' were found to contain the highest levels of bioactive constituents. This research marks the first comprehensive examination of the impacts of these two apricot cultivars. The findings from this study provide a robust scientific foundation for the future isolation and purification of therapeutic compounds, potentially leading to their application in pharmaceuticals or dietary supplements. This research contributes significantly to the understanding of the pharmacological properties of apricot cultivars and establishes a basis for further investigation into their clinical benefits.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- RETRACTED: Phytochemical screening, HPLC fingerprinting and in vitro assessment of therapeutic potentials of different apricot cultivars against diabetes, Alzheimer's disease and cancer
- Date Crossref
- 01/10/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu Division of Fruit Sciences pays non établi dans la noticeUniversité ou école supérieure
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Shri Venkateshwara University pays non établi dans la noticeUniversité ou école supérieure
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King Abdulaziz University Princess Dr. NajlaBint Saud Al-Saud Center for Excellence Research in Biotechnology pays non établi dans la noticeUniversité ou école supérieure
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Chandigarh University pays non établi dans la noticeUniversité ou école supérieure
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King Saud bin Abdulaziz University for Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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Daffodil International University Department of Public Health pays non établi dans la noticeUniversité ou école supérieure
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School of Applied Sciences pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Science Department of Biological Sciences pays non établi dans la noticeUniversité ou école supérieure
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University Centre for Research and Development (UCRD) pays non établi dans la noticeUniversité ou école supérieure
Division of Fruit Sciences — Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Shri Venkateshwara University et Princess Dr. NajlaBint Saud Al-Saud Center for Excellence Research in Biotechnology — King Abdulaziz University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.