Stability of Epinephrine in a Normal Saline Solution
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Objective: Dilution of concentrated epinephrine prior to intravenous use during clinical emergencies can delay urgent interventions. The objective of this study was to determine whether diluted epinephrine remains stable and sterile over time in common hospital settings. Methods: Epinephrine samples were prepared by clinically relevant double dilution techniques. Samples were stored in 10-mL syringes and incubated under 1 of 4 simulated hospital environments with a mixture of lighting and temperature settings: 4°C/20°C, with or without fluorescent lighting. Samples were incubated for 0, 15, 30, 60, or 90 days. Capillary zonal electrophoresis was used to quantify the concentration of epinephrine and/or presence of any degradation products. All samples were tested for the presence of bacterial growth using blood agar cultures. Results: Diluted epinephrine samples remained stable for up to 90 days in all 4 simulated clinical storage conditions. No bacterial colony-forming units were detected in any of the environmental samples regardless of incubation duration, light, or temperature conditions. Conclusion: Diluted epinephrine for anticipated clinical emergencies may remain clinically useful for up to 90 days, thus improving patient safety, access to medications, and overhead costs by reducing waste.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Stability of Epinephrine in a Normal Saline Solution
- Date Crossref
- 01/09/2024
- Éditeur
- American Dental Society of Anesthesiology (ADSA)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of North Carolina at Chapel Hill pays non établi dans la noticeUniversité ou école supérieure
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The Ohio State University Division of Biosciences pays non établi dans la noticeUniversité ou école supérieure
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The Ohio State University Wexner Medical Center pays non établi dans la noticeÉtablissement de santé
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University of North Carolina Adams School of Dentistry Division of Pediatric and Public Health pays non établi dans la noticeUniversité ou école supérieure
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Ohio Agricultural Research and Development Center Metabolite Analysis Cluster pays non établi dans la noticeInstitution
University of North Carolina at Chapel Hill, Division of Biosciences — The Ohio State University et The Ohio State University Wexner Medical Center, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.