Assessment of lesion insertion tool in pelvis PET/MR data with applications to attenuation correction method development
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Le résumé fourni par la source
BACKGROUND: In modern positron emission tomography (PET) with multi-modality imaging (e.g., PET/CT and PET/MR), the attenuation correction (AC) is the single largest correction factor for image reconstruction. One way to assess AC methods and other reconstruction parameters is to utilize software-based simulation tools, such as a lesion insertion tool. Extensive validation of these simulation tools is required to ensure results of the study are clinically meaningful. PURPOSE: To evaluate different PET AC methods using a synthetic lesion insertion tool that simulates lesions in a patient cohort that has both PET/MR and PET/CT images. To further demonstrate how lesion insertion tool may be used to extend knowledge of PET reconstruction parameters, including but not limited to AC. METHODS: Lesion quantitation is compared using conventional Dixon-based MR-based AC (MRAC) to that of using CT-based AC (CTAC, a "ground truth"). First, the pre-existing lesions were simulated in a similar environment; a total of 71 lesions were identified in 18 pelvic PET/MR patient images acquired with a time-of-flight simultaneous PET/MR scanner, and matched lesions were inserted contralaterally on the same axial slice. Second, synthetic lesions were inserted into four anatomic target locations in a cohort of four patients who didn't have any observed clinical lesions in the pelvis. RESULTS: The matched lesion insertions resulted in unity between the lesion error ratios (mean SUVs), demonstrating that the inserted lesions successfully simulated the original lesions. In the second study, the inserted lesions had distinct characteristics by target locations and demonstrated negative max-SUV%diff trends for bone-dominant sites across the patient cohort. CONCLUSIONS: The current work demonstrates that the applied lesion insertion tool can simulate uptake in pelvic lesions and their expected SUV values, and that the lesion insertion tool can be extended to evaluate further PET reconstruction corrections and algorithms and their impact on quantitation accuracy and precision.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Assessment of lesion insertion tool in pelvis PET/MR data with applications to attenuation correction method development
- Date Crossref
- 04/09/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Southern California pays non établi dans la noticeUniversité ou école supérieure
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iSono Health (United States) pays non établi dans la noticeEntreprise
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Washington University in St. Louis pays non établi dans la noticeUniversité ou école supérieure
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University of California pays non établi dans la noticeUniversité ou école supérieure
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University of Washington pays non établi dans la noticeUniversité ou école supérieure
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University of Utah pays non établi dans la noticeUniversité ou école supérieure
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Keck School of Medicine of USC pays non établi dans la noticeUniversité ou école supérieure
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iSono Health Inc. South San Francisco California USA pays non établi dans la noticeEntreprise
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GE Healthcare Waukesha Wisconsin USA pays non établi dans la noticeInstitution
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Washington University School of Medicine in St. Louis St. Louis Missouri USA pays non établi dans la noticeUniversité ou école supérieure
University of Southern California, iSono Health (United States) et Washington University in St. Louis, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.