O03 Developing an electrical impedance sensor to identify platelet content in acute ischemic stroke clots: results from the ex vivo clotbase international registry
Rattachement africain : ie, fr, es, jp, rs, pl. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Introduction Development of a medical device that uses an electrical impedance signature to identify clot characteristics that influence success of treatment could improve stroke patient outcomes. Aim of Study To assess how well electrical impedance platelet signature identified platelet composition of acute ischemic stroke (AIS) clots, which may be negatively associated with successful first-pass effect. Methods Blood clots from 423 patients were analysed in the Clotbase International Registry. Impedance measurements were taken following clot retrieval by thrombectomy. Clot samples were fixed in formalin, paraffin-embedded and platelet composition quantified with anti-CD42b antibody in 3 μm sections using immunohistochemistry. Expression was quantified using Orbit Image Analysis and correlated with impedance estimation. Spearman’s correlation coefficient was calculated using a training set of 305 clots. Mann-Whitney U-test assessed statistically significant differences between groups. Results Impedance-based platelet estimations correlated well with the platelet content determined by CD42b immunohistochemistry, with a slope of 0.6 and Spearman’s correlation of r=0.5 (p<0.0001). In 221 cases, clot was removed successfully in 1 pass with mTICI 2c or better (FPE). FPE was not achieved in 202 cases (including mTICI 0-2b and clot requiring >1 pass). Platelet content was significantly lower in FPE than non-FPE cases as assessed using histology (p=0.02) and impedance signature (p=0.04). Conclusion Electrical impedance estimation of platelet content in AIS clots is consistent with histological findings. Further work will continue to improve the specificity of the impedance signature, advancing development of a medical device that could guide clinical decision making in the stroke acute care setting. Acknowledgments: SFI CÚRAM: 13/RC/2073_P2, SENSOME. Disclosure of Interest no.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- O03 Developing an electrical impedance sensor to identify platelet content in acute ischemic stroke clots: results from the ex vivo clotbase international registry
- Date Crossref
- 01/09/2024
- Éditeur
- BMJ Publishing Group Ltd.
- Type
- proceedings-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Science Foundation Ireland pays non établi dans la noticeOrganisation à but non lucratif
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Ollscoil na Gaillimhe – University of Galway Centre for Research in Medical Devices (CÚRAM)- Science Foundation Ireland (SFI) pays non établi dans la noticeUniversité ou école supérieure
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Laboratoire Ingénierie pays non établi dans la noticeStructure de recherche
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Centre Hospitalier Universitaire de Toulouse pays non établi dans la noticeÉtablissement de santé
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Vall d'Hebron Hospital Universitari pays non établi dans la noticeÉtablissement de santé
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Kobe City Medical Center General Hospital Department of Neurosurgery pays non établi dans la noticeÉtablissement de santé
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Bicêtre Hospital Department of Interventional Neuroradiology pays non établi dans la noticeÉtablissement de santé
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Center for Health pays non établi dans la noticeInstitution
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University Clinical Centre pays non établi dans la noticeÉtablissement de santé
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Centar za Promociju Nauke pays non établi dans la noticeOrganisme public
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Sensome pays non établi dans la noticeInstitution
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Centre Hospitalier Universitaire (CHU) de Toulouse Department of Diagnostic and Therapeutic Neuroradiology pays non établi dans la noticeÉtablissement de santé
Science Foundation Ireland, Centre for Research in Medical Devices (CÚRAM)- Science Foundation Ireland (SFI) — Ollscoil na Gaillimhe – University of Galway et Laboratoire Ingénierie, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.