Accès ouvert déclaré
2024
article
Clinical Significance of Myocardial Injury in Patients Hospitalized for COVID-19
Hunain Shiwani, Jessica Artico, James Moon, Miroslawa Gorecka, Gerry P McCann, Giles Roditi, Andrew Morrow, Kenneth Mangion, Elena Lukaschuk, Mayooran Shanmuganathan, Chris Miller, Amedeo Chiribiri, Mohammed Alzahir, Sara Ramírez, Andrew Lin, Peter Swoboda, Adam K McDiarmid, Robert Sykes, Trisha Singh, Chiara Bucciarelli‐Ducci, Dana Dawson, Marianna Fontana, Charlotte Manisty, Thomas A. Treibel, Eylem Levelt, Robin Young, Alex McConnachie, Stefan Neubauer, Stefan K. Piechnik, Rhodri Davies, Vanessa M. Ferreira, Marc R. Dweck, Colin Berry, John P. Greenwood, J.P. Greenwood, C. Berry, M. Dweck, Connie Miller, Swati Prasad, Dean Dawson, Colin Berry, Giles Roditi, Robin Young, Bernard Kelly, Peter W. Macfarlane, Miroslawa Goreka, Kathryn Somers, R Byrom-Goulthorp, Michelle A. Anderson, Laura E. Britton, Fiona Richards, Laura Jones, Alastair J. Moss, Jude Fisher, Joanne Wormleighton, Kelly Parke, Rachel Wright, Jian L Yeo, Judith Falconer, Paula Henderson, Trisha Singh, David Newby, Iulia A. Popescu, Qiang Zhang, Betty Raman, Keith M. Channon, Catherine Krasopoulos, Claudia Nunes, H. Nixon, Athanasia Panopoulou, Alison Fletcher, Peter Manley, Kirsty Fallon, Ammani Brown, Laura Kelly-Corless, Christopher McGinley, Michael Briscoe, Rosemary Woodward, Tracey Hopkins, Evonne McLennan, Nicola Tynan, Laura Dymock, Judith Wright, Donna Exley, Richard P. Steeds, S.M. MacDonald, Abhishek Shetye, Christopher M. Miller, Christopher Orsborne, William Woodville-Jones, Susan A. Ferguson, Konstantinos Bratis, Timothy Fairbairn, Michail Sionas, Peris Widdows, Pei G. Chew, CA Marsden, Tom Collins, Linsha George, Andrew Flett, Simon Smith, Alice Zhenge, Jake Harvey, Liliana Inacio, Tomas Hanam-Penfold, Yousuf Razvi, Jacolene Crause, Nina M. Davies, James Brown, Liza Chaco, Rishi Patel, Tushar Kotecha, Dan S. Knight, Thomas Green, David P Ripley, Maria Thompson, Ugochi Akerele, Elna Cifra, Ebraham Alskaf, Richard Crawley, Adriana Villa, Angus K. Nightingale, Kim Wright, Esther D. Bonnick, Emma Hopkins, Jessy George, Linta Joseph, Graham Cole, Kavitha Vimalesvaran, Nadine Ali, Alexandra Ross, Clara King, Sanjay Prasad, Zohreh Farzad, Sara Salmi, Kevin G. Kirby, Hannah Stevenson, Pamela S. Matsvimbo, Lency Joji, Margaret Fearby, Benjamin Brown, Nicholas Bunce, Robert B. Jennings, Vennessa Sookhoo, Prathap Kanagala, Sandra Fullalove, Catherine Toohey, Kate Fenlon, Nicholas G. Bellenger, Jingzhou He, Sarah Statton, Nicola Pamphilon, Anna Steele, Claire Ball, Ann McGahey, Silvia Balma, Michelle Walter, Adrian Ionescu, Tishi Ninan, Suzanne H Richards, Marie Williams, Khaled Alfakih, Samia Pilgrim, George Joy, Ifza Hussain
6Citations signalées — pas une note de qualité
23Institutions déclarées
2Pays d’affiliation déclarés
Résumé fourni par la source
BACKGROUND: Hospitalized COVID-19 patients with troponin elevation have a higher prevalence of cardiac abnormalities than control individuals. However, the progression and impact of myocardial injury on COVID-19 survivors remain unclear. OBJECTIVES: This study sought to evaluate myocardial injury in COVID-19 survivors with troponin elevation with baseline and follow-up imaging and to assess medium-term outcomes. METHODS: This was a prospective, longitudinal cohort study in 25 United Kingdom centers (June 2020 to March 2021). Hospitalized COVID-19 patients with myocardial injury underwent cardiac magnetic resonance (CMR) scans within 28 days and 6 months postdischarge. Outcomes were tracked for 12 months, with quality of life surveys (EuroQol-5 Dimension and 36-Item Short Form surveys) taken at discharge and 6 months. RESULTS: Of 342 participants (median age: 61.3 years; 71.1% male) with baseline CMR, 338 had a 12-month follow-up, 235 had a 6-month CMR, and 215 has baseline and follow-up quality of life surveys. Of 338 participants, within 12 months, 1.2% died; 1.8% had new myocardial infarction, acute coronary syndrome, or coronary revascularization; 0.8% had new myopericarditis; and 3.3% had other cardiovascular events requiring hospitalization. At 6 months, there was a minor improvement in left ventricular ejection fraction (1.8% ± 1.0%; P < 0.001), stable right ventricular ejection fraction (0.4% ± 0.8%; P = 0.50), no change in myocardial scar pattern or volume (P = 0.26), and no imaging evidence of continued myocardial inflammation. All pericardial effusions (26 of 26) resolved, and most pneumonitis resolved (95 of 101). EuroQol-5 Dimension scores indicated an overall improvement in quality of life (P < 0.001). CONCLUSIONS: Myocardial injury in severe hospitalized COVID-19 survivors is nonprogressive. Medium-term outcomes show a low incidence of major adverse cardiovascular events and improved quality of life. (COVID-19 Effects on the Heart; ISRCTN58667920).
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clinical Significance of Myocardial Injury in Patients Hospitalized for COVID-19
- Date Crossref
- 01/11/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
COVID-19 Clinical Research StudiesLong-Term Effects of COVID-19Pericarditis and Cardiac Tamponade