Insomnia and sleep duration for kidney function: Mendelian randomization study
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Le résumé fourni par la source
Objectives Extensive researches highlight the detrimental impact of sleep disorders such as insomnia and insufficient sleep duration on kidney function. However, establishing a clear causal relationship between insomnia, sleep duration, and kidney function remains challenging. This study aims to estimate this relationship using Mendelian randomization (MR).Methods Independent genetic variants strongly associated with insomnia (N = 462,341) and sleep duration (N = 460,099) were selected as instrumental variables from corresponding genome-wide association studies (GWAS). Kidney function parameters, including serum creatinine, estimated glomerular filtration rate by cystatin C (eGFRcys), acute renal failure (ARF), chronic renal failure (CRF), kidney injury molecule-1, neutrophil gelatinase associated lipocalin, microalbuminuria, cystatin C, and β2 microglobulin, were derived from GWAS databases. A two-sample MR study was conducted to assess the causal relationship between sleep disorders and kidney function, and multivariable MR was used to identify potential mediators. The inverse-variance weighted was used as the primary estimate.Results MR analysis found robust evidence indicating that insomnia and short sleep duration were associated with an increased risk of elevated serum creatinine, regardless of adjusting for obesity. Causal links between sleep duration and eGFRcys or cystatin C were also identified. While genetically predicted insomnia and sleep duration were found to potentially impact ARF, CRF, microalbuminuria, and β2 microglobulin, the p-values in multivariable MR analysis became nonsignificant. No pleiotropy was detected.Conclusions This study demonstrates a causal impact of insomnia on the risk of elevated serum creatinine and a positive effect of sleep duration on serum creatinine, eGFRcys, and cystatin C. Our findings also suggest their potential indirect effects on ARF, CRF, microalbuminuria, and β2 microglobulin mediated by obesity.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Insomnia and sleep duration for kidney function: Mendelian randomization study
- Date Crossref
- 12/08/2024
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sun Yat-sen University Department of Kidney Transplantation pays non établi dans la noticeUniversité ou école supérieure
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Third Affiliated Hospital of Sun Yat-sen University pays non établi dans la noticeÉtablissement de santé
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Wenzhou Medical University Department of Urology pays non établi dans la noticeUniversité ou école supérieure
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Quzhou City People's Hospital pays non établi dans la noticeÉtablissement de santé
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Quzhou University pays non établi dans la noticeUniversité ou école supérieure
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Key Laboratory of Guangdong Province pays non établi dans la noticeStructure de recherche
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Guangdong Provincial Key Laboratory of Diabetology pays non établi dans la noticeStructure de recherche
Department of Kidney Transplantation — Sun Yat-sen University, Third Affiliated Hospital of Sun Yat-sen University et Department of Urology — Wenzhou Medical University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.