Correlation between serum advanced glycation end-products and vascular complications in patient with type 2 diabetes
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Advanced glycation end-products (AGEs) formation increases with metabolic disorders, leading to higher serum AGE levels in patients with progressive vascular complications. Measuring AGE levels in biological samples requires multiple pre-analytical processing steps, rendering analysis of multiple samples challenging. This study evaluated the progression of diabetic complications by analyzing AGE levels using a pre-analytical processing strategy based on a fully automated solid phase-extraction system. Serum samples from patients with diabetes, with or without macrovascular complications (Mac or non-Mac) or microvascular complications (Mic or non-Mic), were processed with the established methods. Free and total AGE levels in sera were measured using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). In patients with diabetes, both free and total AGE levels were elevated in those with complications compared to those without complications. In Mac and Mic groups, free and total AGE levels and z-scores (the sum of normalized AGE levels) also increased. AGE z-scores were markedly higher than those of single AGE levels in distinguishing each complication. Our study demonstrated that the free AGE z-score, measured using a new analytical method without hydrolysis, correlated with the presence of vascular complications and may serve as a marker of disease complications.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Correlation between serum advanced glycation end-products and vascular complications in patient with type 2 diabetes
- Date Crossref
- 12/08/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kyushu Tokai University pays non établi dans la noticeUniversité ou école supérieure
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Kumamoto University pays non établi dans la noticeUniversité ou école supérieure
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Tokai University pays non établi dans la noticeUniversité ou école supérieure
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Graduate School of Bioscience Laboratory of Food and Regulation Biology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Life Science Department of Metabolic Medicine pays non établi dans la noticeUniversité ou école supérieure
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School of Agriculture Laboratory of Food and Regulation Biology pays non établi dans la noticeUniversité ou école supérieure
Kyushu Tokai University, Kumamoto University et Tokai University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.