Retrospective Study on the Features and Outcomes of a Tuscany COVID-19 Hospitalized Patients Cohort: Preliminary Results
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Le résumé fourni par la source
Background: A few months after the COVID-19 pandemic onset, knowledge of SARS-CoV-2 infection and outcomes and treatments blew up. This paper aimed to evaluate the features of a Tuscany COVID-19 hospitalized cohort and to identify risk factors for COVID-19 severity. Methods: This retrospective observational COVID-19 cohort study (1 March 2020–1 March 2021) was conducted on patients ≥ 18 years old, admitted to Tuscany Hospital, and subjected to follow-up within 12 months after discharge. Patients were enrolled at Pisana, Senese and Careggi University Hospitals, and South East, North West, and Center Local Hospitals. Results: 2888 patients (M = 58.5%, mean age = 66.2 years) were enrolled, of whom 14.3% (N = 413) were admitted to an intensive care unit. Smokers were 25%, and overweight and obese 65%. The most used drugs were corticosteroids, antacids, antibiotics, and antithrombotics, all antiviral drugs, with slight differences between 2020 and 2021. A strong association was found between outcomes of evolution towards critical COVID-19 (non-invasive mechanical ventilation (NIV) and/or admission to intensive care) and smoking (RR = 4.91), ex-smoking (RR = 3.48), overweight (RR = 1.30), obese subjects (RR = 1.62), comorbidities (aRR = 1.38). The alteration of liver enzymes (aspartate aminotransferase, alanine aminotransferase, or gamma-glutamyl transpeptidase) was associated with NIV (aOR = 2.28). Conclusions: Our cohort, characterized by patients with a mean age of 66.2 years, showed 65% of patients were overweight and obese. Smoking/ex-smoking, overweight/obesity, and other comorbidities were associated with COVID-19 adverse outcomes. The findings also demonstrated that alterations in liver enzymes were associated with worse outcomes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Retrospective Study on the Features and Outcomes of a Tuscany COVID-19 Hospitalized Patients Cohort: Preliminary Results
- Date Crossref
- 07/08/2024
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Siena Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Ospedale San Donato pays non établi dans la noticeÉtablissement de santé
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Azienda Ospedaliera Universitaria Senese pays non établi dans la noticeÉtablissement de santé
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Ospedale San Giuseppe pays non établi dans la noticeÉtablissement de santé
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University of Florence Department of Experimental and Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
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Regional Health Agency of Tuscany Epidemiology Unit pays non établi dans la noticeOrganisme public
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Infectious Diseases Unit pays non établi dans la noticeInstitution
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Apuane Hospital AUSL Toscana Nord-Ovest pays non établi dans la noticeÉtablissement de santé
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Pisa University Hospital Pneumology Unit pays non établi dans la noticeUniversité ou école supérieure
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Diabetes and Metabolic Diseases Unit pays non établi dans la noticeInstitution
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Siena University Department Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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San Giuseppe Hospital Internal Medicine II and Stroke Unit pays non établi dans la noticeÉtablissement de santé
Department of Medicine — University of Siena, Ospedale San Donato et Azienda Ospedaliera Universitaria Senese, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.