Danilo Tacconi

Molecular evidence of neuroinvasive Sindbis virus infection in humans: detection in cerebrospinal fluid by next generation sequencing

Maria Grazia Cusi, Gianni Gori Savellini, Chiara Cassol, Cesira Nencioni et autres

Sindbis virus (SINV) is a mosquito-borne alphavirus causing seasonal outbreaks in northern Europe, Africa, and Russia. Neurological involvement in humans is poorly documented, and detection in cerebrospinal fluid (CSF) has not previously been reported. This study provides the first unequivocal evidence of …

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Current practices and challenges in the management of acute bacterial skin and skin structure infections (ABSSSI): results from an Italian multicentre survey with expert discussion

Lidia Gazzola, Matteo Augello, Silvia Cavinato, Antonio Briozzo et autres

Background and objectives: Acute bacterial skin and skin structure infections (ABSSSI) are common infections associated with relevant clinical and organizational burden. Their management requires appropriate antibiotic therapy and integrated healthcare organization; however, real-world practices remain heterogeneous. The objective was to explore current …

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Changing in blood cells for infection detection: “Monocyte distribution width” acts as a key determinant in differentiating localized and blood stream infections

Agostino Ognibene, Maria Lorubbio, Sara Montemerani, Giulio Camarlinghi et autres

BACKGROUND: Early identification of bloodstream infections (BSI) in the Emergency Department (ED) remains a clinical challenge. Monocyte Distribution Width (MDW), a novel biomarker available from the complete blood count, was prospectively evaluated for its diagnostic and prognostic utility in patients with suspected …

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Durability of Long‐Acting Cabotegravir + Rilpivirine in Virologically Suppressed Adults Living With HIV: A Multicenter Observational Cohort in Tuscany (LAHIV)

Filippo Lagi, Giuseppe Formica, Massimiliano Fabbiani, Barbara Rossetti et autres

To evaluate the durability of long-acting cabotegravir (CAB) plus rilpivirine (RPV), available in Italy since June 2022, for maintaining HIV-1 virological suppression. This multicentric observational study included 191 virologically suppressed adults (HIV-RNA < 50 copies/mL) from 11 centers in Tuscany, followed from …

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Changing in Blood Cells for Infection Detection: The Significance of “Monocyte Distribution Width” in Sepsis Prevention

Agostino Ognibene, Maria Lorubbio, Sara Montemerani, Tommaso Novi et autres

Background/Objectives: Blood is often the first organ to show changes during local or systemic infection, but common definitions of sepsis rarely include CBC findings in risk assessment tools. Infection remains the main cause of sepsis, which Sepsis-3 defines as life-threatening organ dysfunction …

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Evaluation of short and long-term laboratory and instrumental findings in COVID-19 patients hospitalized in Tuscany

Caterina Silvestri, Cristina Stasi, Francesco Profili, Simone Bartolacci et autres

BACKGROUND: The World Health Organization defined long coronavirus disease 2019 (COVID-19) as the continuation or development of new symptoms 3 months after the initial severe acute respiratory syndrome coronavirus 2 infection, with these symptoms lasting for at least 2 months with no …

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P95 Metabolic and immunological outcomes after switching to long-acting cabotegravir + rilpivirine: a 44-week multicenter observational study (LAHIV)

Filippo Lagi, Marco Fognani, Giuseppe Formica, G Gasparro et autres

SC30 Real-world discontinuation and virological outcomes of long-acting cabotegravir + rilpivirine in virologically suppressed adults living with HIV: a multicenter observational study in Tuscany (LAHIV)

Filippo Lagi, Giuseppe Formica, Massimiliano Fabbiani, Barbara Rossetti et autres

The Uprise of Human Leishmaniasis in Tuscany, Central Italy: Clinical and Epidemiological Data from a Multicenter Study

Anna Barbiero, Michele Spinicci, Andrea Aiello, Martina Maruotto et autres

Human leishmaniasis is facing important epidemiological changes in Southern Europe, driven by increased urbanization, climate changes, emerging of new animal reservoirs, shifts in human behavior and a growing population of immunocompromised and elderly individuals. In this evolving epidemiological landscape, we analyzed the …

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Retrospective Study on the Features and Outcomes of a Tuscany COVID-19 Hospitalized Patients Cohort: Preliminary Results

Caterina Silvestri, Cristina Stasi, Francesco Profili, Simone Bartolacci et autres

Background: A few months after the COVID-19 pandemic onset, knowledge of SARS-CoV-2 infection and outcomes and treatments blew up. This paper aimed to evaluate the features of a Tuscany COVID-19 hospitalized cohort and to identify risk factors for COVID-19 severity. Methods: This …

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Hepatitis C epidemiology and treatment outcomes in Italy: Impact of the DAA era and the COVID ‐19 pandemic

Maria Paola Tramonti Fantozzi, Luca Ceccarelli, Davide Petri, Erica De Vita et autres

HCV infection poses a global health threat, with significant morbidity and mortality. This study examines HCV trends in a large Italian region from 2015 to 2022, considering demographic changes, evolving clinical profiles, treatment regimens and outcomes, including the impact of the COVID-19 …

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Hepatitis C Virus (HCV) genotypes distribution in South-Eastern Tuscany: a ten-year retrospective study.

Agostino Ognibene, Giulio Camarlinghi, Maria Lorubbio, Manuela Mafucci et autres

Italy is recognized as having the highest Hepatitis C virus (HCV) prevalence in Europe. The Tuscany region, where the prevalence of HCV infection is approximately 0.8%, implemented two programs for the control of chronic hepatitis C in Tuscany from 2018 to 2022. …

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