Survival among people with HIV and their families in Denmark 1995–2021: a nationwide population-based cohort study
Rattachement africain : dk. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Survival among people with HIV (PWH) has vastly improved globally over the last few decades but remains lower than among the general population. We aimed to estimate time trends of survival among PWH and their families from 1995 to 2021. Methods: We conducted a registry-based, nationwide, population-based, matched cohort study. We included all Danish-born PWH from 1995 to 2021 who had been on antiretroviral therapy for 90 days, did not report intravenous drug use, and were not co-infected with hepatitis C (n = 4168). We matched population controls from the general population 10:1 to PWH by date of birth and sex (n = 41,680). For family cohorts, we identified siblings, mothers, and fathers of PWH and population controls. From Kaplan-Meier tables with age as time scale, we estimated survival from age 25. We compared PWH with population controls and families of PWH with families of population controls to calculate mortality rate ratios adjusted for sex, age, comorbidities, and education (aMRR). Findings: The median age of death among PWH increased from 27.5 years in 1995-1997 to 73.9 years (2010-2014), but thereafter survival increased only marginally. From 2015 to 2021, mortality was increased among PWH (aMRR 1.87 (95% CI: 1.65-2.11)) and siblings (aMRR: 1.25 (95% CI: 1.07-1.47)), mothers (aMRR: 1.30 (95% CI: 1.17-1.43)), and fathers (aMRR: 1.15 (95% CI: 1.03-1.29)) of PWH compared to their respective control cohorts. Mortality among siblings of PWH who reported heterosexual route of HIV transmission (aMRR: 1.51 (95% CI: 1.16-1.96)) was higher than for siblings of PWH who reported men who have sex with men as route of HIV transmission (aMRR 1.19 (95% CI: 0.98-1.46)). Interpretation: Survival among PWH improved substantially until 2010, after which it increased only marginally. This may partly be due to social and behavioural factors as PWH families also had higher mortality. Funding: Preben and Anna Simonsen's Foundation and Independent Research Fund Denmark.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Survival among people with HIV and their families in Denmark 1995–2021: a nationwide population-based cohort study
- Date Crossref
- 01/08/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Statens Serum Institut Department of Infectious Disease Epidemiology and Prevention pays non établi dans la noticeStructure de recherche
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Aarhus University Hospital Department of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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Copenhagen University Hospital Department of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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Rigshospitalet pays non établi dans la noticeÉtablissement de santé
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Hvidovre Hospital pays non établi dans la noticeÉtablissement de santé
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University of Southern Denmark Research Center of Infectious Diseases pays non établi dans la noticeUniversité ou école supérieure
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Odense University Hospital Department of Infectious Diseases pays non établi dans la noticeOrganisme public
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Zealand University Hospital Department of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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Aalborg University Hospital Department of Clinical Medicine pays non établi dans la noticeÉtablissement de santé
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Aalborg University pays non établi dans la noticeUniversité ou école supérieure
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Herlev Hospital pays non établi dans la noticeÉtablissement de santé
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Aarhus University pays non établi dans la noticeUniversité ou école supérieure
Department of Infectious Disease Epidemiology and Prevention — Statens Serum Institut, Department of Infectious Diseases — Aarhus University Hospital et Department of Infectious Diseases — Copenhagen University Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.