Experimental inoculation of pigs with monkeypox virus results in productive infection and transmission to sentinels
Rattachement africain : us, Ouganda. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Monkeypox virus (MPXV) is a re-emerging zoonotic poxvirus responsible for producing skin lesions in humans. Endemic in sub-Saharan Africa, the 2022 outbreak with a clade IIb strain has resulted in ongoing sustained transmission of the virus worldwide. MPXV has a relatively wide host range, with infections reported in rodent and non-human primate species. However, the susceptibility of many domestic livestock species remains unknown. Here, we report on a susceptibility/transmission study in domestic pigs that were experimentally inoculated with a 2022 MPXV clade IIb isolate or served as sentinel contact control animals. Several principal-infected and sentinel contact control pigs developed minor lesions near the lips and nose starting at 12 through 18 days post-challenge (DPC). No virus was isolated and no viral DNA was detected from the lesions; however, MPXV antigen was detected by IHC in tissue from a pustule of a principal infected pig. Viral DNA and infectious virus were detected in nasal and oral swabs up to 14 DPC, with peak titers observed at 7 DPC. Viral DNA was also detected in nasal tissues or skin collected from two principal-infected animals at 7 DPC post-mortem. Furthermore, all principal-infected and sentinel control animals enrolled in the study seroconverted. In conclusion, we provide the first evidence that domestic pigs are susceptible to experimental MPXV infection and can transmit the virus to contact animals.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Experimental inoculation of pigs with monkeypox virus results in productive infection and transmission to sentinels
- Date Crossref
- 11/06/2024
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kansas State University pays non établi dans la noticeUniversité ou école supérieure
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Animal and Plant Health Inspection Service pays non établi dans la noticeOrganisme public
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United States Department of Agriculture pays non établi dans la noticeOrganisme public
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Centers for Disease Control and Prevention pays non établi dans la noticeOrganisme public
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Centers for Disease Control and Prevention Ouganda (code pays fourni par la source)Organisme public
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Louisiana State University pays non établi dans la noticeUniversité ou école supérieure
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Agricultural Research Service pays non établi dans la noticeOrganisme public
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College of Veterinary Medicine Department of Diagnostic Medicine/Pathobiology pays non établi dans la noticeUniversité ou école supérieure
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Foreign Animal Disease Diagnostic Laboratory pays non établi dans la noticeStructure de recherche
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Foreign Arthropod-Borne Animal Diseases Research Unit pays non établi dans la noticeStructure de recherche
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School of Veterinary Medicine Louisiana Animal Disease Diagnostic Laboratory and Department of Pathobiological Sciences pays non établi dans la noticeUniversité ou école supérieure
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Zoonotic and Emerging Disease Research Unit pays non établi dans la noticeStructure de recherche
Kansas State University, Animal and Plant Health Inspection Service et United States Department of Agriculture, avec 9 autres affiliations. Pays d’affiliation : Ouganda.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.