Accès ouvert déclaré 2024 article

Effects of icosapent ethyl according to baseline residual risk in patients with atherosclerotic cardiovascular disease: results from REDUCE-IT

P.M. Burger, Deepak L. Bhatt, Jannick A N Dorresteijn, Stefan Koudstaal, Arend Mosterd, Fabrice M A C Martens, Philippe Gabríel Steg, Frank L.J. Visseren, Joanne Ladner, Lily Kakish, Ashley Kakish, Amy L. Little, Jaime Gerber, Nancy J. Hinchion, Janet Guarino, Denise Raychok, Susan Budzinski, Kathleen Kelley-Garvin, April Beckord, Jessica Schlinder, Arthur Z. Schwartzbard, Stanley E. Cobos, Deborah Freeman, David Abisalih, Dervilla McCann, Kylie Guy, Jennifer Chase, Stacey Samuelson, Madeline A. Cassidy, Marissa Tardif, Jaime Smith, Brenna Sprout, Nanette Riedeman, Julie Goza, Lori A Johnson, Chad Kraske, Sheila Hastings, Chris Dutka, Stephanie Shintani Smith, Toni McCabe, Kathleen H. Maloney, Paul Alfieri, Vinay Hosemane, Chanhsamone Syravanh, Cindy Ta Pau, April Limcoiloc, Tabitha Carreira, Taryn S. Kurosawa, Razmig Krumian, Krista Preston, Ashraf H. Nashed, Daria Schneidman-Fernandez, Jack Patterson, John Tsakonas, J Esaki, Lynn Sprafka, Porous Patel, Brian J. Mitchell, Erin M. Ross, Donna Miller, Akash Prashad, Kristina M. Feyler, Natasha Juarbe, Sandra Rocio Herrera, Sarah M. Keiran, Becky Whitehead, Whitney Asher, Coury Hobbs, Abbey Elie, Jean Brooks, Amanda L. Zaleski, Brenda Foxen, Barb Lapke, Philippa Wright, Bristol Pavol, Gwen Carangi, Marla Turner, Howard Ellison, Katharine W. Sanders, Rikita S. Delamar, Virginia L. Wilson, Sarah M. Harvel, Alison M. Cartledge, Kaitlyn R. Bailey, Kathleen A. Mahon, Timothy Schuchard, Jennifer Humbert, Mark C. Hanson, Michael P. Cecil, James S. Abraham, Lorie Benedict, Claudia Slayton, Curtis Burnett, Rachel W. Ono-Lim, Sharon Budzinski, Shubi A. Khan, Sharon Goss, Terry Techmanski, Farida Valliani, Rimla Joseph, Edith Flores, Laurn Contreras, Ana Aguillon, Carrie-Ann Silvia, María Dolores Martín, Edmund Kenneth Kerut, Leslie W. Levenson, Louis B. Glade, Brian Cospolich, Maureen W. Stein, Stephen P. Laguardia, Thelma L. Sonza, Tracy M. Fife, Melissa Forschler, Jasmyne Watts, Judy Fritsch, Emese Futchko, Sarah Utech, Scott Baker, Miguel F. Roura, DAVID R. SUTTON, Scott A. Segel, James S. Magee, Cathy Jackson, Rebecca F. Goldfaden, Liudmila Quas, Elizabeth Ortiz, Michael F. Simpson, Robert E. Foster, Cosgrove Brian, James Trimm, Michael Bailey, Brian Snoddy, Van C. Reeder, Rachel Wilkinson, Harold P. Settle, Cynthia Massey, Angela Maiola, Michele Hall, Shelly Hall, Wanda Hall, Mark Xenakis, J. C. Barrett, Giovanni Campanile, David Anthou, Susan F. Neill, Steven P. Karas, Enrique Polanco, Norberto Schechtman, Grace Tischner, Kay Warren, Cynthia St Cyr, Menna Kuczinski, Maricruz Ibarra, Barry S. Horowitz, Jaime Steinsapir, Jeanette Mangual-Coughlin, Brittany Mooney, Precilia Vasquez, Kathleen Rodkey, Alexandria Biberstein, Christine Ignacio, Irina Robinson, Marcia Hibberd, Lisa B. Hoffman, Daniel J. Murak, Raghupathy Varavenkataraman, T. Elliott, Linda A. Cunningham, Heather L. Palmerton, Sheri Poole, Jeannine M. Moore, Ted Chandler, Robert W. Riley, Farah Z. Dawood, A.M. Abdul Azeem, Michael Cammarata, Ashleigh A. Owen, Shivani Aggarwal, Waqas Qureshi, Mohamed Faher Almahmoud, Abdullahi Oseni, Adam Leigh, Erin W Barnes, Adam Pflum, Amer I. Aladin, Karen Blinson, Vickie Wayne, Lynda Doomy, Michele Wall, Valerie Bitterman, Cindi A. Young, Rachel Grice, Lioubov Poliakova, Jorge Davalos, DAVID S. ROSENBAUM, Mark E. Boulware, Heather Mazzola, James R. Strader, Russell A. Linsky, David Asa Schwartz, Elizabeth Graf, Alicia Gneiting, Melissa Palmblad, Ashley Donlin, Emily Ensminger, Dawn M. Robinson, Carolyn Tran, Jeffrey Jacqmein, Darlene Bartilucci, Michael A. Koren, Barbara Maluchnik, Melissa K. Parks, Jennifer R. B. Miller, Cynthia DeFosse, Albert B. Knouse, Amy Delancey, Stephanie A. Chin, Thomas Stephens, Mag Sohal, Juana Ingram, Swarooparani Kumar, Heather A. Foley, Nina C Smith, Vera McKinney, Linda Schwarz, Judith Moore, H. Vernon Anderson, Stefano Sdringola-Maranga, Ali Emin Denktas, Elizabeth Turrentine, Rhonda Patterson, John C. Marshall, Terri Tolar, Donna Patrick, Pamela Schwartzkopf, Anthony M. Fletcher, Frances R. Harris, Sherry Clements, Tiffany Brown, William T. Smith, Stacey J. Baehl, Robin Fluty, Daniel VanHamersveld, Dennis Breen, Nancy Bender, Beverly Stafford, Tamika L. Washington, Margaret N. Pike, Mark A. Stich, Evyan Jawad, Amin Ur Rehman Nadeem, Jill Nyland, Rhonda Hamer, Kendra Calhoun, Charlotte Mall, Samuel Cadogan, Kati Raynes, Richard J. Katz, Lorraine R. Marshall, R Abbas, JAY L. DINERMAN, John T. Hartley, Beth Lamb, Lisa Eskridge, Donna Raymond, Kristy Clemmer, Denise M. Fine, Paula Beardsley, Janet Werner, Bette Mahan, Courtney VanTol, Robert Herman, Christine Raiser-Vignola, Felicia McShan, Stefanie A. Neill, David R. Blick, Michael J. Liston, Denetta K. Nelson, Sandra K. Dorrell, Patricia Wyman, AMBEREEN QURAISHI, Fernando Portilho Ferro, Frank Morris, Vicki J. Coombs, Autumn Mains, Austin A. Campbell, Jeanne Phelps, Cheryl A. Geary, Ellen G. Sheridan, J Downing, Arie Swatkowski, Tish Redden, Brian Dragutsky, Susan E. Thomas, Candace A. Mitchell, Diana Barker, Elanie Turcotte, Deborah Segerson, J. Guy, Karena De La Mora, Jennifer Hong, Dennis Do, R M Norris, Faisal Rashid Khan, Stacy Kelly-White, Alan S. Cleland, Rosalyn Alcalde-Crawford, Melissa Morgan, Brijmohan Sarabu, Megan Minor, Shweta Kamat, Stephanie M. Estes, Nancee Harless, A. P. S. Disney, Jodi L. Pagano, C. Alford, Noel W. Bedwell, Warren D. Hardy, Kevin Deandrade, Jessica G. Elmore, Anthony Haney, Miriam H. Brooks, Jose Torres, Terry Backer, Katie Backer, John Grayson Evans, Ricardo A. Silva, Lorraine H. Dajani, Veronica Yousif, Sion K. Roy, Ronald J. Oudiz, Sajad A. Hamal, Ferdinand R. Flores, A. L. Leahy, Debra Ayer, Swapna George, Chrisi Carine Stewart, Elvira Orellana, Cristina Boccalandro, Mary Rangel, Suzanne Hennings, Carl Vanselow, Teri Victor, Darlene Birdwell, Paul F. Haas, Anthony Sandoval, Gina Ciavarella, Caroline Saglam, Amy L. Bird, Keith Beck, Brian Poliquin, David Dominguez, Brittany Tenorio, Harvonya Perkins, Esther San Roman, Paris Bransford, Christy Lowrance, Marcy Broussard, Mary R. Ellis, Bobbi Skiles, Jessica Hamilton, Kathryn Hall, Diego Olvera, Julee Hartwell, Nevien Sorial, Kishlay Anand, Mary Rickman, Kevin S. Berman, Nirav J. Mehta, Annie Laborin, Rodger W. Rothenberger, Sarah Beauvilliers, Kathy Morrell, Michael P. Schachter, Cindy L. Perkins, Elizabeth A. Gordon, Jennifer Lauer, Kim Bichsel, Kelly A. Oliver, Leslie J. Mellor, Candice Demattia, Jennifer Schomburg, Yenniffer Moreno, Eduardo Mansur-Garza, Lena Rippstein, L. Chacon, Andrea Pena, Michelle King, Susan Richardson, Annette Jessop, Nicole Tucker, Whitney Royer, Gilbert Templeton, Ann Moell, Christine L. Weller, Melissa J. Botts, Gretel Hollon, Elsa Homberg-Pinassi, Paula K. Forest, Aref Bin Abhulhak, Devona Chun-Furlong, Deborah K. Harrington, Emily L. Harlynn, Marjorie Schmitt, Constance Shelsky, Patricia Feldick, Mary Cherrico, Courtney Jagle, Nicholas Warnecke, Debra Myer, Deanna J. Ruder, A. J. V. Underwood, Alan Rauba, George Carr, Barbara Oberhaus, Jessica Vanderfeltz, Mary Jo Stucky-Heil, Dale R. Gibson, Vonnie Fuentes, Kimberly L. Talbot, William C. Simon, Katlyn J. Grimes, Christina R. Wheeler, Cassaundra Shultz, Rhonda A. Metcalf, Jennifer Hill, Michelle R. Oliver, Ahmad Basharat, Fouzal Azeem, Abdul Rahim, George H. Freeman, Dawn Bloch, Heather Freeman, Jamie Brown, Sarah Rosbach, Pamela Melander, Nick Taralson, Alex C.H. Liu, K. Harms, Mahfouz Michale, José Luis García López, Maria Revoredo, Shari Edevane, Sarah Shawley, Timothy L. Jackson, MICHAEL J. OLIVER, Dina DeSalle, Patricia J. Matlock, Ionna M. Beraun, H Hendrix, G. Bromley, Ashley Niemerski, Gabby Teran, Sonia Guerrero, Murtaza Marvi, Zehra Palanpurwala, Andrea D. Torres, Patty Gloyd, Michelle Conger, Aziz L. Laurent, Olia Nayor, Catalina S. Villanueva, Munira Khambati, Tabetha J. Mumford, Melanie J. Castillo, Taddese Desta, Jerome Robinson, La Shawn Woods, Anita H Bahri, Nancy D. Herrera, Cecilia Casaclang, Jeffrey R. Unger, Mia K. Moon, Stephen Mohaupt, Larry Sandoval, Louisito Valenzuela, Victora Ramirez, Nelly Mata, Veronica Avila, Cynthia Montano-Pereira, O. Y. Barnett, William M. Webster, Lorraine M. Christensen, Leighna Bofman, Melanie Livingston, Stacey Adams, Joseph Hobbs, Leesa Koskela, Mia Katz, Samuel Mujica-Trenche, Franklin Cala, Noreen T. Rana, Jennifer Scarlett, Milagros Cala Anaya, Marsha Jones, Kelly D. Hollis, Debbie Roth, Kristin Eads, Tina Watts, Judy Perkins, Alice M. Arnold, Daniel C. Ginsberg, Denise Quinn, Nicole Cureton, David B. Fittingoff, Mohammed I. Iqbal, Stephen White, Edith Sisneros, Michelle Ducca, David Streja, Danny A. Campos, Jennifer Boak, Farzeen Amir, Felice Anderson, James J. Kmetzo, Mary O. Bongarzone, Dawn Scott, Mary Grace De Leon, Cynthia Buda, William F. Graettinger, Michelle Alex, E V Hess, James Govoni, Melissa Bartel, Travis Monchamp, Julie S. Roach, Sara A. Gibson, Amy M. Allfrey, Kristen Timpy, Kathy Bott, Karin A. Soucy, Jean Willis, Cecilia A. Valerio, A. Chunduri, Rebecca Coker, Nicole Vidrine, Ellen A. Thompson, Mark A. Studeny, Melissa K. Marcum, Tammy S. Monway, Douglas Kosmicki, Melissa J. Kelley, Corey M. Godfrey, Susan L. Krenk, Randy R. Holcomb, Deb K. Baehr, Mary K. Trauernicht, David R. Lowry, Betty Bondy Herts, Jean-Marie Downing, Carol Gamer Dignon, Elisabeth S. Cockrill, Pravinchandra G. Chapla, Diane Fera, MARGARET A. CHANG, Patricia Fredette, Tamie Ashby, Renee Bergin, Zebediah A Stearns, David B. Ware, Rachael M. Boudreaux, Francisco G Miranda, Joanna Rodriguez, Robert Tracy McKenzie, Amanda K. Huber, Rebecca Sommers, Heather J. Rowe, Stacy McLallen, M Haynes, Ashley Adamson, Janice Henderson, Lori McClure, Beverly A. Harris, Laura Ference, Sue Meissner-Dengler, Lisa Treasure, Doreen Nicely, Timothy L. Light, Tracey Osborn, Pablo E. Vivas, José Ríos, Dúnia Rodriguez, Roger DeRaad, James S. Walder, Oscar Bailon, Denice Hockett, Debbie Anderson, Kelli McIntosh, Amber Odegard, Andrew D. Shepherd, Laurence Kelley, Rajendra Shetty, Michael J. Castine, David Brill, Gregory L. Fisher, Nicole Richmond, Patricia A. Miller, Charlene Coneys, Yarixa Chanza, Monica Sumoza, Victoria M. Caudill, Kelly D. Harris, Courtney A. Manion, Melody Lineberger-Moore, Julie J. Wolfe, Barbara J. Rosen, Patricia Divito, Janet L. Moffat, Christina Michaelis, Prashant Koshy, D. Perea, Ghaith Al Yacoub, Stephanie Sadeghi, Thomas D. LeGalley, Rudolph F. Evonich, William J. Jean, Gary M. Friesen, J M Pap, David A. Pesola, Mark D. Cowan, Kristofer Dosh, Dianna M. Larson, Adele M. Price, Jodi A. Nease, Jane Anderson, Lori A. Piggott, Robert Iwaoka, Kevin Sharkey, Edward McMillan, Laurie Lowder, Latisha Morgan, Kyle Davis, Erica Breglio, Jasmine Summers, Rachel Poulimas, Muhammad Zahid, Hamid S Syed, Maria Escobar, Jacob T. Levy, Rahma Warsi, Carol Ma, Puxiao Cen, Kimberly A. Cawthon, Delores B. Barnes, Deanna G. Allen, Margaret L. Warrington, Carol R. Stastny, Robin J. Michaels, Mohamad Ali Saleh, John Sorin, Sunny Rathod, Urakay Juett, Steven Spencer, Aziza Keval, Jill McBride, Shane Young, Catherine Baxter, Carol A. Rasmussen, Shari L. Coxe, Luís Campos, Shahin Tavackoli, Diana Beckham, Darlynee Sanchez, Karanjit Basrai, Dorian Helms, Erica Clinton, Kasie Smith, Arnold Ghitis, Henry Cusnir, Mary Klaus Clark, Madhavagopal Cherukuri, Ameta Scarfaru, Stephen D. Nash, Loretta C. Grimm, anna grace, Kylie McElheran, Dino Subasic, Zedrick Buhay, Janet Litvinoff, Deepak Kumar Shah, Shannon Cervantes, Freda Usher, Theodor Trusevich, Ronnie L. Garcia, Jamison Wyatt, Rahul Bose, Holllilyn Miska, Traci Spivey, Amy B. Wren, Katie E. Vance, Lani L. Holman, P. Gibbons, E. Eby, Sandra Shepard, Soratree Charoenthongtrakul, Brett Thomas Snodgrass, Mohammed Nazem, Shelly Keteenburg, Prathima Murthy, Frederic Prater, Ashley Rumfelt, Christina Eizensmits, Lisa Iannuzzi, Pourus R. Patel, Clellia Bergamino, Elizabeth McFeaters, Botros Rizk, Emiljia Pflaum, Danny Kalish, Rex Ambatali, Mona Ameli, Delaina Sanguinetti, Rakesh Vaidya, Robert J. Bos, Alexandra Wils, Tamara Jacobs, Erik Badings, L. A. Ebels-Tuinbeek, Mayke L. Scholten, Esther Bayraktar-Verver, Debby Zweers, Manoek Schiks, Carolien Kalkman, Tineke Tiemes, Jeanette Mulderij, Walter R. M. Hermans, K Dabrowska, Wilma Wijnakker, Ronald K. Loo, Jennifer A. deGraauw, Giny Reijnierse, Mirjam van der Zeijst, Mariska Scholten, Henk R. Hofmeijer, Antoinette van Dijk-van der Zanden, Dineke J. van Belle, Jan van Es, Gera Van Buchem, Wendy Zijda, Harald Verheij, Linnea Oldenhof-Janssen, Martina Bader, Marije M. Löwik, Sandra Stuij, Pascal J.M.J Vantrimpont, Krista van Aken, Karen K. Hamilton, Arno van der Weerdt, Han Blömer, Gabriela van Laerhoven, Raymond Tukkie, Maarten C. W. Janssen, Gerard Verdel, J. Küpper, Bob van Vlies, Caroline Kalkman, Joke Vooges, M. Vermaas, Jeanne de Graauw, Riny Van de Loo, Rachel Langenberg, N Haenen, F. A. M. Smeets, Arko Scheepmaker, Marcel J. W. Grosfeld, Ilvy van Lieshout, Marleen H van den Berg, M. E. Wittekoek, Petra Mol, Antionette Stapel, Marion J. Sierevogel, N vd Ven, A Berkelmans, Eric P. Viergever, Hanneke Kramer, Wilma Engelen, K van Houwelingen, Thierry X. Wildbergh, Coriet Hobé-Rap, Marjan van Doorn, Petra Bunschoten, Michel Freericks, Mireille E. Emans, Petra Den Boer-Penning, Els Verlek, Christine Freericks, Cornelis de Nooijer, Christina Welten, Ingrid Groenenberg, C van der Horst, E Vonk, Geert Tjeerdsma, Gerard M. Jochemsen, Corinne van Daalen, I. Danse, L. Kuipers, Anke Pieterse, Antonius Oomen, Daan de Waard, Willem Jan Flu, Z. Kromhout, Petra Van der Bij, Rob Feld, Brigitta Hessels-Linnemeijer, Rob Lardinois, Jan L. Posma, Zwanette R. Aukema-Wouda, Marjolijn Hendriks-van Woerden, Desiree van Wijk, Driek Beelen, Ingrid H. Hendriks, Jan J C Jonker, Stefanie Schipperen, Vicdan Köse, Gloria Rojas, Linda Goedhart, Hanneke van Meurs, Jacqueline Rijssemus, Jacqueline Hoogendijk, Lindy Swinkels-Diepenmaat, Wouter van Kempen, Marloes de Louw-Jansen, Dominique Bierens-Peters, Marianne E. Wittekoek, Irmaina Agous, Geert J. Schenk, Willem W. van Kempen, Janneke Wittekoek, Kevin Cox, Deborah Font Julia, Roel Janssen, Melchor Nierman, Hilligje Katerberg, Irene van der Haar, Taco van Mesdag, Leyda M. Alvarez Costa, Manon Schensema, Salomé Zweekhorst, Lauri Hanewinckel, Joyce Olsthoorn, Johan C Berends, Arie C. van der Spek, Roy van der Berg, Rob J. Timmermann, I Boerema, Iryna Mudruk, Anna Khrystoforova, S. M. Kyselov, Y.V. Hilova, Pavlo Logoida, Nataliia A. Sanina, Ilona P Golikova, Olena Nemchyna, Ivan I. Isaichikov, Olga Potapova, Iurii V. Gura, Larysa Berestetska, О. О. Кулянда, Oleksandr Tantsura, O. S. Kulbachuk, Volodymyr Petsentiy, Ihor Biskub, Tetyana Handych, Oleg Lagkuti, Alyna Gagarina, Taras Chendey, O. Bilonko, Olena O Matova, Larysa Bezrodna, O. Yarynkina, Tetiana Ovdiienko, Volodymyr Randchenko, Maryna Mospan, O. O. Butko, Olga Romanenko, Mykhailo Pavelko, Iryna Sichkaruk, Світлана Олексіївна Лазарева, Olena A. Kudryk, Inessa M. Koltsun, T. Magdalits, Sergei Zadorozhniy, Kira Kompaniiets, Andrii Ivanov, Sergiy Romanenko, Pavlo Kaplan, В Ю Романов, Oksana Mykytyuk, Н. С. Зайцева, Sergiy N. Pyvovar, Lyudmyla Burdeuna, Emerita Serdobinska, Татьяна Ивановна Шевченко, Igor I. Ivanytskyi, Olena V. Khyzhnyak, Н. В. Калинкина, Olena Keting, Olena Sklyanna, Olga Kashanska, A. N. Shevelok, Marina Khristichenko, Ievgenii Y. Titov, Danilenko O. Oleksander, Nataliia S. Polenova, Н. В. Алтуніна, Viktoriia Kororaieva, Stanislav Zborovskiy, Leonid Kholopov, Iurii Suliman, Л. В. Лукашенко, Stanislav Shvaykin, Olexandr M. Glavatskiy, Roman O. Sychov, R Kulynych, O. A. Skarzhevskyi, Н. Довган, Marta Horbach, О. П. Черкасова, И. А. Тыщенко, Liudmyla Todoriuk, Світлана Кізім, Nataliia Brodi, O. V. Ivanko, Olga Garbarchuk, Liudmyla Alieksieieva, Tetiana L. Shandra, Olena Beregova, Larisa Bodretska, Світлана Наскалова, Іванна Антонюк-Щеглова, O. V. Bondarenko, Natalia G. Andreeva, Iryna I. Vakalyuk, O CHOVGANYUK, N.R. Artemenko, K. A. Maltsev, Natalia Kalishevich, Natalia G. Kondratyeva, S A Nikitina, Maria V. Martjanova, Anna V. Sokolova, Д. О. Драгунов, Olga Kolesnik, Vera N. Larina, Oxana Tsygankova, Maria O. Ivanova, Illia A. Karpov, Elena M. Aronova, E. S. Vedernikova, Ekaterina I. Lubinskaya, T. Ya. Burak, Sergey I. Skichko, Farhad Rasulev, Ekaterina B. Soldatova, Alexander L. Fenin, Ilya I. Laptev, Е. Е. Лучинкина, Alexandr Akatov, N. Polenova, Natalia N. Slavina, Irina N. Korovnika, Marina Yu Prochorova, R. M. Shakirova, Elena N. Andreicheva, Olga A. Krasnova, Tinatin V. Lobzhanidze, Т Б Дмитрова, Viktoriya V. Stakhiv, Maria I. Pechatnikova, Alexandra V. Panova, Maria Y. Tipikina, Oxana Rotar, Nikolay Bokovin, Saule Karabalieva, Farid Tumarov, Е. В. Васильева, Н. Г. Ложкина, Ekaterina V. Filippova, Alisa I. Sharkaeva, Natalia Yu Tolkacheva, Elena N. Domracheva, I. T. Abesadze, М. З. Алугишвили, Е. П. Николаева, N. V. Smirnova, Valentina I. Rodionova, Polina V. Dolovstaya, I. E. Yunonin, Sergey V. Kadin, Т. С. Свеклина, Anna V. Bushmanova, E. Barkova, Irina S. Gomova, Yana Valerevna Brytkova, Tatiana B. Ivanova, M. Yu. Zubareva, I. S. Skopets, Lybov A. Galashevskaya, Emilia D. Butinskaya, Olga G. Gusarova, Yana R. Pavlova, M. P. Serebrenitskaya, Vitalina F. Grygorieva, Gulnara R. Kuchaeva, Inna A. Vasileva, G. Ospanova, Yulia V. Vahrusheva, I. A. Semenova, Irina E.E. Mikhailova, Olga O. Kvasova, Valeria Shurygina, Alexey E. Rivin, Alexey O. Savelyev, Olesya O. Milyaeva, Nadezhda N. Lapshina, Ninel A. Lantsova, Pavel V. Alexandrov, Evgeniy A. Orlikov, А. Yu. Falkovskaya, Tatiana M. Ripp, Sergey V. Triss, Stanislav E. Pekarskiy, Sitkova Ekaterina, Evgeniya N. Zhuravleva, Olga Perova, Г. П. Ковалева, Л. Н. Мищенко, Boris P. Garshin, Svetlana Kutuzova, Lyudmila I. Provotorova, Igor P. Zadvorny, Ольга Владимировна Охапкина, А. О. Хрусталев, Tatiana Suvorova, Elena S. Shaf, Varvara A. Vershinina, A. A. Kozulin, O. A. Oleynik, Irina Martynova, Н. В. Кижватова, Alla Sergeevna Salasyuk, В. В. Цома, Alla A. Ledyaeva, Elena V. Chumachek, Suzanne Blignaut, Tersia Y. Alexander, Thirumani Govender, Samatha M. Du Toit, Leya Motala, Areesh Gassiep, Christina Naude, Marli Terblanche, Marlien Snoer, Berenice Pillay, De Vries Basson, Clive H. Corbett, Marisa E. Theron, Bianca Fouche, M. Coetzee, Pieter Odendall, F.H. van Wijk, Anna-Mari Conradie, Trudie Van der Westhuizen, Carine Tredoux, Mohamed S. Mookdam, Andie J. Van der Merwe, Karin Snyman, Gerda Smal, Y Jäger, Thomas A. Mabin, Annusca King, Lindy L. Henley, Brenda M. Zwane, Jane Robinson, Marinda Karsten, Andonia M. Page, Valerie Nsabiyumva, Charmaine Krahenbuhl, Jaiprakash D. Patel, Yunus E. Motala, Ayesha Dawood, Nondumiso B. Koza, Lenore M.S. Peters, Shavashni Ramlachan, Wilhelm J. Bodenstein, Pierre‐Yves Le Roux, Lizelle Fouche, Cecilia M. Boshoff, Haroon Mitha, Fathima Khan, Henry P Cyster, Helen Cyster, E. C. Wessels, Florence J. Jacobs, Melanie A. Sebastian, Deborah A. Sebastian, N. Mahomed, Ignatius Immink, Celia Cotzee, Tanja Cronje, Madele Roscher, M Roux, Yvonne A. Trinder, Renata Wnętrzak-Michalska, Magdalena Piszczek, Andrzej Piela, Ewa Czernecka, Dorota Knychas, Alina Walczak, Izabella Gładysz, Katarzyna Filas, Ewelina Kiluk, Krzysztof Świgło, Iwona Jędrzejczyk, Kamila Łuczyńska, Katarzyna Tymendorf, Wojciech Piesiewicz, Wojciech L. Kinasz, Stefan Samborski, Ilona Bartuś, Gramzyna Latocha Korecka, Ewa Gulaj, Jolanta Sopa, Bogusław Derlaga, Marcin Baisiak, A Kowalisko, Edyta Stainszewska-Marasazlek, Bartosz Szafran, Małgorzata Świątkiewicz, Artur J. Racewicz, Sławomir Grycel, Jerzy Supronik, Sylwia Walendziuk, Magdalena Tarantowicz, Agata Stasiak, Anna Sidorowicz-Białynicka, Marek Dwojak, Ewa Jaźwińska−Tarnawska, K. Kupczyk, Kamila Martowska, Kamila Kulon, Katarzyna Gajda, Bivin Wilson, Krithika Velusamy, Swaidha S. Sadhiq, Bhavani Siddeshi, M Bhanukumar, Abhishek Srivatsav, Madhan Ramesh, Sri Harsha Chalasani, Mini Johnson, Prashanth Gopu, Jeesa George, Sowmya Somashekar Reddy, Swetha Tessy Thara Eleena, Damodara Rao Kodem, Haritha N. Nakkella, Padma Kumari Mandula, Anjan Kumar Vuriya, Syamala Rajana, Aruna Kale, Rajeev Tiwari, Raina Jain, Vipin Kailasmal Jain, Srilakshmi Mandayam Adhyapak, Lumin Sheeba, Chandrasekar Uma, Aditya V. Kulkarni, Madiwalayya Shivakantayya Ganachari, Ruma Sambrekar, Mohammad Bilal, Kalyan Chakravarthy, Ravi Badhavath, Sravan Kumar, Meenakshi Simhadri, Farooque Salamuddin, Venkat Prasad, Vivek Dwivedi, Sudha Sarna, Tilak Arora, Deepak Chawla, Archana Sathe, Chaware Gayatree, Ajeet Nanda, Ram Avtar, JYOTI DHAR SHARMA, Vaibhavi P S Sasirekha D, Deepthi Kobbajji, Ramya Ningappa, Shwetha Shree, Kiran Chandrashekar, S. Sowjanya, I G Devika, N Yashaswini, L Rathna, Rupal J. Shrimanker, Lakshmi Vinutha Reddy, Kolamala Sumathi, Babitha Devi, Bina N. Naik, Rohini Manjunath, Tony V. Kunjumon, Jesline Thomas, Shaik Samdhani, Kasthuri Selvam, Poongothai Subramani, Nandakumar Parthasarathy, Nirmal K. Bohra, Anvesh K. Gatla, Cheryl Horbatuk, Julie Sills, Emily Davey, Liz Paramonczyk, Olga Racanelli, David C. Crowley, Sandy Strybosch, André Bélanger, Jean Palardy, Alicia Schiffrin, Sylvie F. Gauthier, Norman Kalyniuk, Shawn D. Whatley, Heather Lappala, Grishma J. Patel, Matthew Reeve, Catherine Nora Moran, Jody Everitt, Teresa Cristina Abreu Ferrari, Christine Bouffard, Jirir Frohlich, Gordon Francis, John A. Mancini, Gregory P. Bondy, Patricia Fulton, David W. Blank, Angela M. Lombardo, Mylène Roy, Jackie Chow, Hyman Fox, William J. Grootendorst, Angela B. Hutchinson, S. Chan, Christie Fitzgerald, Lynn Wilkins, Rebecca L. Raymond, Arlene Reyes, Lavoie Marc André, Denis Fortin, Hélène Ouimet, Thanh-Thao Tôn-Nu, Martine Dussureault, Marie-Hélène Blain, Madeleine Roy, Nathalie Kopajko, Chantal Fleury, Karine Maheux, Gabriela Valentina Ciobotaru, Maria C. Constantinescu, Carmen-Lucia Gherghinescu, Anamaria Avram, Ioan Maniţiu, Radu I. Cojan, Octavian M. Pirvu, Aura Sinpetrean, Lucian Gheorghe Pop, Delia Lupu, Radu Usvat, Ana Petrişor, Nicoleta Dumitru, Camelia Moruju, Adelina Gheorghita, Magda Mitu, Cosmin Macarie, Ana Maria Pop, Iulia Grancea, Mihaela Cosma, Mihaela Crisan, Elizabeth Herron, Anthony Michael Dart, Paul John Nestel, Sally B Kay, K. Carter, Imran Badshah, Ashley Makepeace, Jocelyn J. Drinkwater, Michelle England, Azette Rafei, Kylie Patterson, Alicia Josephine Jenkins, Sybil A. McAuley, Sue M. Kent, Joy E. Vibert, Leonie Perrett, Samantha L. Kaye, Monika O’Connor, Nimalie Perera, Kerry A. Kearins, Christinia Dicamillo, Heather D. Anderson, Louise Ferguson, S. Radtke, Charles T. Thamarappillil, Janice M. Boys, A. Long, Toni Shanahan, Michael Nyguyen, Nicole Forrest, D Greenwell, Sarah L. Price, Aye Nyein Tint, Priya Sumithran, Tamara L. Debreceni, Lisa A.S. Walker, Mary Caruana, Kira Edwards, Maria Stathopoulos, Cilla J. Haywood, Dimitar Sajkov, S. Pringle, Anne Tabner, Kathrina Bartolay, Chamindi Abeyratne, Kylie Bragg, Patrick Mulhern, Peter Purnell, Randall Hendriks, Lyn Williams, Jane Hamlyn, Aurelia Connelly, Jan Hoffman, Samantha Bailey, Jane Kerr, Zarnia Morrison, Sarah Maeder, Roberta McEwan, Prasanna Kunasekera, Patrice McGregor, Jo Young, Sharon E. Berry, Rick Cutfield, Michelle Choe, Catherine M. McNamara, Narrinder K. Shergill, Petra Crone, Miles Williams, Keith Dyson, Diana H. Schmid, Audrey C. Doak, Melissa Spooner, Colin C. Edwards, Anne Turner, Gráinne McAnnalley, Raewyn A. Fisher, Fraser Hamilton, Denis H. Friedlander, Melissa R. Kirk, Jayne Scales, Marguerite A. McLelland, Neelam Dalman, Cathy E. Vickers, Carolyn Chang Jackson, W. Patrick Coleman, Phillip I. Garden, Wendy F. Arnold

5Citations signalées, ce qui n’est pas une note de qualité
12Institutions déclarées
3Pays d’affiliation déclarés

Rattachement africain : nl, us, fr. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

AIMS: Icosapent ethyl lowers triglycerides and significantly reduces major adverse cardiovascular events (MACE), though treatment effects may vary between individuals. This study aimed to determine the relative and absolute effects of icosapent ethyl on MACE according to baseline cardiovascular disease (CVD) risk in patients with atherosclerotic cardiovascular disease (ASCVD). METHODS AND RESULTS: Participants from the Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial (REDUCE-IT) with ASCVD were included (n = 5785). The primary outcome was 3-point MACE, i.e. non-fatal myocardial infarction, non-fatal stroke, or cardiovascular death. Baseline 5-year risk of MACE was estimated using the European Society of Cardiology (ESC) guideline-recommended SMART2 risk score. Modification of the relative treatment effects of icosapent ethyl by baseline risk was assessed using Cox proportional hazards models, including a treatment-by-risk interaction. Next, treatment effects were assessed stratified by quartiles of baseline risk. During a median follow-up of 4.8 years (interquartile range 3.2-5.3), MACE occurred in 361 vs. 489 patients in the icosapent ethyl vs. placebo group [95% confidence interval (CI)]; hazard ratio (HR) 0.72 (0.63-0.82), absolute risk reduction (ARR) 4.4% (2.6-6.2%), number needed to treat (NNT) 23 (16-38), and 5-year Kaplan-Meier estimated cumulative incidence reduction (CIR) 5.7% (3.5-7.9%). Icosapent ethyl significantly reduced MACE in all risk quartiles, with an HR (95% CI) of 0.62 (0.43-0.88), 0.66 (0.48-0.92), 0.69 (0.53-0.90), and 0.78 (0.63-0.96), respectively (P for treatment-by-risk interaction = 0.106). The ARR (95% CI) increased across risk quartiles, i.e. was 3.9% (1.0-6.8%), 4.3% (1.2-7.3%), 5.1% (1.4-8.7%), and 5.6% (1.3-10.0%), respectively. This translates to NNTs (95% CI) of 26 (15-98), 24 (14-84), 20 (11-70), and 18 (10-77). The 5-year CIR (95% CI) was 4.8% (1.3-8.2%), 5.0% (1.3-8.7%), 6.1% (1.7-10.5%), and 7.7% (2.3-13.2%), respectively. Consistent results were obtained for 5-point MACE, additionally including coronary revascularization and unstable angina. CONCLUSION: Among patients with ASCVD and elevated triglyceride levels, icosapent ethyl significantly reduces the risk of MACE irrespective of baseline CVD risk, though absolute benefits are largest for patients at the highest risk.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref
Effects of icosapent ethyl according to baseline residual risk in patients with atherosclerotic cardiovascular disease: results from REDUCE-IT
Date Crossref
27/04/2024
Éditeur
Oxford University Press (OUP)
Type
journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

  • University Medical Center Utrecht pays non établi dans la notice
    Établissement de santé
  • Mount Sinai Health System Mount Sinai Heart pays non établi dans la notice
    Établissement de santé
  • Icahn School of Medicine at Mount Sinai pays non établi dans la notice
    Université ou école supérieure
  • Meander Medisch Centrum pays non établi dans la notice
    Établissement de santé
  • Amsterdam Neuroscience pays non établi dans la notice
    Structure de recherche
  • Amsterdam University Medical Centers pays non établi dans la notice
    Établissement de santé
  • University of Amsterdam pays non établi dans la notice
    Université ou école supérieure
  • Université Paris Cité pays non établi dans la notice
    Université ou école supérieure
  • Assistance Publique – Hôpitaux de Paris pays non établi dans la notice
    Établissement de santé
  • Alliance nationale pour les sciences de la vie et de la santé pays non établi dans la notice
    Organisme public
  • Inserm pays non établi dans la notice
    Organisme public
  • Laboratoire de Recherche Vasculaire Translationnelle pays non établi dans la notice
    Structure de recherche

University Medical Center Utrecht, Mount Sinai Heart — Mount Sinai Health System et Icahn School of Medicine at Mount Sinai, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Fatty Acid Research and HealthLipoproteins and Cardiovascular HealthCardiovascular Health and Disease Prevention
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