Differences in Gut Microbiota Profiles and Microbiota Steroid Hormone Biosynthesis in Men with and Without Prostate Cancer
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Le résumé fourni par la source
Background: Although prostate cancer (PCa) is the most common cancer in men in Western countries, there is significant variability in geographical incidence. This might result from genetic factors, discrepancies in screening policies, or differences in lifestyle. Gut microbiota has recently been associated with cancer progression, but its role in PCa is unclear. Objective: Characterization of the gut microbiota and its functions associated with PCa. Design setting and participants: In a prospective multicenter clinical trial (NCT02241122), the gut microbiota profiles of 181 men with a clinical suspicion of PCa were assessed utilizing 16S rRNA sequencing. Outcome measurements and statistical analysis: Sequences were assigned to operational taxonomic units, differential abundance analysis, and α- and β-diversities, and predictive functional analyses were performed. Plasma steroid hormone levels corresponding to the predicted microbiota steroid hormone biosynthesis profiles were investigated. Results and limitations: , the most abundant genus of the cohort, and significantly higher in PCa patients. Predictive functional analyses revealed higher 5-α-reductase, copper absorption, and retinol metabolism in the PCa-associated microbiome. Plasma testosterone was associated negatively with the predicted microbial 5-α-reductase level. Conclusions: Gut microbiota of the PCa patients differed significantly compared with benign individuals. Microbial 5-α-reductase, copper absorption, and retinol metabolism are potential mechanisms of action. These findings support the observed association of lifestyle, geography, and PCa incidence. Patient summary: In this report, we found that several microbes and potential functions of the gut microbiota are altered in prostate cancer compared with benign cases. These findings suggest that gut microbiota could be the link between environmental factors and prostate cancer.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Differences in Gut Microbiota Profiles and Microbiota Steroid Hormone Biosynthesis in Men with and Without Prostate Cancer
- Date Crossref
- 01/04/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Turku Research Center for Infections and Immunity pays non établi dans la noticeUniversité ou école supérieure
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Turku University Hospital Department of Clinical Microbiology pays non établi dans la noticeÉtablissement de santé
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Mass General Brigham pays non établi dans la noticeÉtablissement de santé
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University of Gothenburg Department of Internal Medicine and Clinical Nutrition pays non établi dans la noticeUniversité ou école supérieure
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Åbo Akademi University pays non établi dans la noticeUniversité ou école supérieure
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Turku Centre for Computer Science pays non établi dans la noticeStructure de recherche
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Enterprise Service Group - Radiology pays non établi dans la noticeInstitution
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Biocodex: Biocodex Nordics pays non établi dans la noticeInstitution
Research Center for Infections and Immunity — University of Turku, Department of Clinical Microbiology — Turku University Hospital et Mass General Brigham, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.