How Sex Hormones Affect Migraine: An Interdisciplinary Preclinical Research Panel Review
Rattachement africain : us, se. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Sex hormones and migraine are closely interlinked. Women report higher levels of migraine symptoms during periods of sex hormone fluctuation, particularly during puberty, pregnancy, and perimenopause. Ovarian steroids, such as estrogen and progesterone, exert complex effects on the peripheral and central nervous systems, including pain, a variety of special sensory and autonomic functions, and affective processing. A panel of basic scientists, when challenged to explain what was known about how sex hormones affect the nervous system, focused on two hormones: estrogen and oxytocin. Notably, other hormones, such as progesterone, testosterone, and vasopressin, are less well studied but are also highlighted in this review. When discussing what new therapeutic agent might be an alternative to hormone therapy and menopause replacement therapy for migraine treatment, the panel pointed to oxytocin delivered as a nasal spray. Overall, the conclusion was that progress in the preclinical study of hormones on the nervous system has been challenging and slow, that there remain substantial gaps in our understanding of the complex roles sex hormones play in migraine, and that opportunities remain for improved or novel therapeutic agents. Manipulation of sex hormones, perhaps through biochemical modifications where its positive effects are selected for and side effects are minimized, remains a theoretical goal, one that might have an impact on migraine disease and other symptoms of menopause. This review is a call to action for increased interest and funding for preclinical research on sex hormones, their metabolites, and their receptors. Interdisciplinary research, perhaps facilitated by a collaborative communication network or panel, is a possible strategy to achieve this goal.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- How Sex Hormones Affect Migraine: An Interdisciplinary Preclinical Research Panel Review
- Date Crossref
- 07/02/2024
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Association of Migraine Disorders pays non établi dans la noticeOrganisation à but non lucratif
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North Carolina State University pays non établi dans la noticeUniversité ou école supérieure
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North Central State College pays non établi dans la noticeUniversité ou école supérieure
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Washington University in St. Louis pays non établi dans la noticeUniversité ou école supérieure
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Brigham and Women's Hospital pays non établi dans la noticeÉtablissement de santé
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Stanford University Department of Anesthesia pays non établi dans la noticeUniversité ou école supérieure
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University of Colorado Denver pays non établi dans la noticeUniversité ou école supérieure
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Lund University Department of Clinical Sciences pays non établi dans la noticeUniversité ou école supérieure
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NC State University Department of Biological Sciences pays non établi dans la noticeUniversité ou école supérieure
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Washington University School of Medicine Division of Clinical and Translational Research pays non établi dans la noticeUniversité ou école supérieure
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University of Colorado School of Medicine Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
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Brain Performance Center and Research Institute pays non établi dans la noticeStructure de recherche
Association of Migraine Disorders, North Carolina State University et North Central State College, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.