Prevention and management of VZV infection during pregnancy and the perinatal period

Résumé fourni par la source

• As an infection, chickenpox is more severe in pregnant women than in adults; it exposes the unborn child to three risks: congenital varicella syndrome, potentially severe neonatal varicella, and herpes zoster. • In the event of VZV contamination in a non-immunized pregnant woman, first-line prophylaxis consists in administration of anti-VZV immunoglobulins during the ten days following contact, at a dose of 0.5 to 1 ml /kg (IVL). • Maternal chickenpox during the seven days before and after birth can lead to severe neonatal chickenpox; this situation justifies administration in the child of anti-VZV immunoglobulins as soon as possible following birth (10 days maximum). • Occurrence of maternal chickenpox during the 21 days before and after birth can lead to severe neonatal chickenpox in a child born before 28 weeks of amenorrhea or weighing less than 1000 g at birth; this situation justifies administration in the child of anti-VZV immunoglobulins as soon as possible after birth (10 days maximum).

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.