Robert W. Cohen

Consensus Definition for Community-acquired Pneumonia in Children Using a Delphi Approach

Sarah Dutron, Joana Pissarra, Anna Deguet, Léa Domitien et autres

BACKGROUND: Although community-acquired pneumonia (CAP) is one of the most common infections in children, no standardized criteria for diagnosis exist. The objective of this study was to develop expert consensus for the diagnosis of pediatric CAP in countries with a high level …

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RSV immunization and Acute Otitis Media: perspectives beyond the first season

Inès Fafi, Corinne Lévy, Romain Basmaci, Robert W. Cohen et autres

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Respiratory Syncytial Virus Shapes Serotype-Specific Invasive Pneumococcal Disease Dynamics in Children: An Observational Study

Inès Fafi, Corinne Lévy, Emmanuelle Varon, Robert W. Cohen et autres

BACKGROUND: Pneumococcal nasopharyngeal colonization is the first step toward invasive pneumococcal disease (IPD). Respiratory syncytial virus (RSV) may trigger IPD, particularly for serotypes with low disease potential.We aimed to analyse the distribution of pneumococcal serotypes among paediatric IPD according to RSV circulation …

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Real-world Constraints Should Not Be Mistaken for Methodologic Weakness

Robert W. Cohen, Stéphane Béchet, Corinne Lévy

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Quantifying the mechanisms of vaccine-induced serotype replacement in Streptococcus pneumoniae using genome-informed modelling

Zein Assad, Kévin La, Corinne Lévy, Robert W. Cohen et autres

Abstract Streptococcus pneumoniae is a colonizer of the child’s nasopharynx and a leading cause of invasive pneumococcal disease (IPD). Despite widespread use of pneumococcal conjugate vaccines, recent rebounds in IPD incidence have coincided with serotype replacement. Whether this phenomenon is driven by …

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Dependencies in heterogeneous, lineage plastic patient–derived prostate cancer organoids revealed through integrated single–cell multiomics and CRISPR screening

Samir Zaidi, Maren Büttner, Weiran Feng, Caitlin Baxter et autres

Lineage plasticity and tumor heterogeneity limit the effectiveness of targeted therapies, yet the functional dependencies used to nominate therapeutic targets are often derived from homogeneous systems that fail to capture this complexity. Here, we establish a framework to resolve state-specific genetic vulnerabilities …

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Is the Interplay Between Maternal Tdap and Pneumococcal Conjugate Vaccines Relevant to Infant Pneumococcal Carriage?

C. Michael Levy, Ron Dagan, Stéphane Béchet, Robert W. Cohen

To The Editor—Maternal pertussis vaccination has been implemented for more than a decade in numerous countries and has demonstrated substantial benefits in preventing pertussis among young infants. In the absence of a monovalent pertussis vaccine, this strategy necessarily relies on combination vaccines …

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Characterization of Streptococcus pyogenes isolates from French children: emm-1 genotype is associated with invasive infections and spread of the M1UK clone

Philippe Bidet, Anna Giolito, Corinne Levy, Robert W. Cohen et autres

BACKGROUND: The bacterial determinants of Group A Streptococcus (GAS) associated with either invasive (IGASI) or non-invasive (NIGASI) infections remain controversial. METHODS: From 2014 to 2018, French children hospitalized for an IGASI were enrolled in a prospective multicenter study aimed at identifying bacterial …

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Interpretation of Respiratory Syncytial Virus Immunization Impact on Pediatric Acute Otitis Media: Key Considerations

Inès Fafi, Corinne Lévy, Romain Basmaci, Robert W. Cohen et autres

To the editor—We thank Ling Ting and Sheu for their insightful comments on our recently published article in Clinical Infectious Diseases, assessing the impact of respiratory syncytial virus (RSV) immunization on the rate of pediatric acute otitis media (AOM) in France [1]. …

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EE488 Health Economic Analysis of Risk- and Age-Based Pneumococcal Vaccination With PCV21 vs. PCV20 in France

Oluwaseun Sharomi, Manon Breau-Brunel, Robert W. Cohen, John Lang

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Post-COVID-19 resurgence of Mycoplasma pneumoniae infections in French children (ORIGAMI): a retrospective and prospective multicentre cohort study

Anaïs Chosidow, Zoha Maakaroun-Vermesse, Vichita Ok, Cécile Delecroix et autres

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Epidemiology and economic burden of hospitalizations attributable to Respiratory Syncytial Virus (RSV) infection among infants in France, 2016 to 2023 – EPIBREATHE study

Robert W. Cohen, Marta C. Nunes, Alexis Rybak, Louis Chillotti et autres

OBJECTIVES: Most of the clinical and economic burden of Respiratory Syncytial Virus (RSV) in pediatric populations is concentrated among infants aged < 1 year. This study aimed to estimate the recent incidence, healthcare costs and rehospitalization risk associated with RSV-related hospitalizations in …

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