Accès ouvert déclaré 2024 review

Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis

Abrar Ahmad, Lee‐Ling Lim, Mario Luca Morieri, Claudia H.T. Tam, Feifei Cheng, Tinashe Chikowore, Monika Dudenhöffer‐Pfeifer, Hugo Fitipaldi, Chuiguo Huang, Sarah Kanbour, Sudipa Sarkar, Robert W. Koivula, Ayesha A. Motala, Sok Cin Tye, Gechang Yu, Yingchai Zhang, Michele Provenzano, Diana Sherifali, Russell J. de Souza, Deirdre K. Tobias, Jordi Merino, Catherine Aiken, Jamie L. Benham, Dhanasekaran Bodhini, Amy L. Clark, Kevin Colclough, Rosa Corcoy, Sara J. Cromer, Daisy Duan, Jamie L. Felton, Ellen C. Francis, Pieter Gillard, Véronique Gingras, Romy Gaillard, Eram Haider, Alice E. Hughes, Jennifer M. Iklé, Laura M. Jacobsen, Anna R. Kahkoska, Jarno L. T. Kettunen, Raymond J. Kreienkamp, Jonna M. E. Männistö, Robert Massey, Niamh‐Maire Mclennan, Rachel G. Miller, Jasper Most, Rochelle N. Naylor, Bige Ozkan, Kashyap Patel, Scott J. Pilla, Katsiaryna Prystupa, Sridharan Raghavan, Mary R. Rooney, Martin Schön, Zhila Semnani‐Azad, Magdalena Sevilla-González, Pernille Svalastoga, Wubet Worku Takele, Anne Cathrine B. Thuesen, Mustafa Tosur, Amelia S. Wallace, Caroline C. Wang, Jessie J. Wong, Jennifer M. Yamamoto, Katherine Young, Chloé Amouyal, Mette K. Andersen, Maxine P. Bonham, Mingling Chen, Sian C. Chivers, Christoffer Clemmensen, Dana Dabelea, Adem Y. Dawed, Aaron J. Deutsch, Laura T. Dickens, Linda A. DiMeglio, Carmella Evans‐Molina, María Mercè Fernández-Balsells, Stephanie L. Fitzpatrick, Stephen E. Gitelman, Mark O. Goodarzi, Jessica A. Grieger, Marta Guasch‐Ferré, Nahal Habibi, Torben Hansen, Arianna Harris-Kawano, Heba M. Ismail, Benjamin Hoag, Randi K. Johnson, Angus G. Jones, Aaron Leong, Gloria K. W. Leung, Ingrid Libman, Kai Liu, S. Alice Long, William L. Lowe, Robert W. Morton, Suna Önengüt-Gümüşcü, James S. Pankow, Maleesa Pathirana, Sofia Pazmiño, Dianna Perez, John R. Petrie, Camille E. Powe, Alejandra Quinteros, Rashmi Jain, Debashree Ray, Mathias Ried‐Larsen, Zeb Saeed, Vanessa Santhakumar, Gabriela S. F. Monaco, Denise Scholtens, Elizabeth Selvin, Wayne Huey‐Herng Sheu, Cate Speake, Maggie A. Stanislawski, Nele Steenackers, Andrea K. Steck, Norbert Stefan, Julie Støy, Rachael W. Taylor, Gebresilasea Gendisha Ukke, Marzhan Urazbayeva, Bart Van der Schueren, Camille Vatier, John M. Wentworth, Wesley Hannah, Sara L. White, Shao J. Zhou, Jacques Beltrand, Michel Polak, Ingvild Aukrust, Elisa De Franco, Sarah E. Flanagan, Kristin A. Maloney, Andrew McGovern, Janne Molnes, Mariam Nakabuye, Pål R. Njølstad, Hugo Pomares‐Millan, Cécile Saint‐Martin, Cuilin Zhang, Yeyi Zhu, Sungyoung Auh, Andrea J. Fawcett, Chandra Gruber, Eskedar Getie Mekonnen, Emily Mixter, Robert H. Eckel, John J. Nolan, Louis H. Philipson, Rebecca J. Brown, Liana K. Billings, Kristen E. Boyle, Tina Costacou, John Dennis, José C. Florez, Anna L. Gloyn, Peter A. Gottlieb, Siri Atma W. Greeley, Kurt Griffin, Andrew T. Hattersley, Irl B. Hirsch, Marie‐France Hivert, Korey K. Hood, Jami L. Josefson, Soo Heon Kwak, Lori M. Laffel, Siew Lim, Ruth J. F. Loos, Ronald C.W., Chantal Mathieu, Nestoras Mathioudakis, James B. Meigs, Shivani Misra, Viswanathan Mohan, Rinki Murphy, Richard A. Oram, Katharine R. Owen, Susan E. Ozanne, Ewan R. Pearson, Wei Perng, Toni I. Pollin, Rodica Pop‐Busui, Richard E. Pratley, Leanne M. Redman, María J. Redondo, Rebecca M. Reynolds, Robert K. Semple, Jennifer L. Sherr, Emily K. Sims, Arianne Sweeting, Miriam S. Udler, Kimberly K. Vesco, Tina Vilsbøll, Róbert Wágner, Stephen S. Rich, Paul W. Franks, Maria F. Gomez

48Citations signalées — pas une note de qualité

162Institutions déclarées

26Pays d’affiliation déclarés

Résumé fourni par la source

BACKGROUND: Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with Type 2 diabetes (T2D). METHODS: We conducted a systematic review and meta-analysis of longitudinal studies to identify potentially novel prognostic factors that may improve CVD risk prediction in T2D. Out of 9380 studies identified, 416 studies met inclusion criteria. Outcomes were reported for 321 biomarker studies, 48 genetic marker studies, and 47 risk score/model studies. RESULTS: Out of all evaluated biomarkers, only 13 showed improvement in prediction performance. Results of pooled meta-analyses, non-pooled analyses, and assessments of improvement in prediction performance and risk of bias, yielded the highest predictive utility for N-terminal pro b-type natriuretic peptide (NT-proBNP) (high-evidence), troponin-T (TnT) (moderate-evidence), triglyceride-glucose (TyG) index (moderate-evidence), Genetic Risk Score for Coronary Heart Disease (GRS-CHD) (moderate-evidence); moderate predictive utility for coronary computed tomography angiography (low-evidence), single-photon emission computed tomography (low-evidence), pulse wave velocity (moderate-evidence); and low predictive utility for C-reactive protein (moderate-evidence), coronary artery calcium score (low-evidence), galectin-3 (low-evidence), troponin-I (low-evidence), carotid plaque (low-evidence), and growth differentiation factor-15 (low-evidence). Risk scores showed modest discrimination, with lower performance in populations different from the original development cohort. CONCLUSIONS: Despite high interest in this topic, very few studies conducted rigorous analyses to demonstrate incremental predictive utility beyond established CVD risk factors for T2D. The most promising markers identified were NT-proBNP, TnT, TyG and GRS-CHD, with the highest strength of evidence for NT-proBNP. Further research is needed to determine their clinical utility in risk stratification and management of CVD in T2D.

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Contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis
Date Crossref: 22/01/2024
Éditeur: Springer Science and Business Media LLC
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.

Institutions déclarées

Lund University Chinese University of Hong Kong University of Malaya Asia Diabetes Foundation University of Padua Dalian Medical University Second Affiliated Hospital of Chongqing Medical University Chongqing Medical University University of the Witwatersrand Johns Hopkins University Johns Hopkins Medicine University of Oxford Oxford Centre for Diabetes, Endocrinology and Metabolism University of KwaZulu-Natal Joslin Diabetes Center University Medical Center Groningen Azienda USL di Bologna University of Bologna Population Health Research Institute McMaster University Impact Hamilton Health Sciences Harvard University University of Copenhagen Novo Nordisk Foundation Massachusetts General Hospital University of Cambridge Rosie Hospital University of Calgary Madras Diabetes Research Foundation Cardinal Glennon Children’s Medical Center Saint Louis University University of Exeter Universitat Autònoma de Barcelona Instituto de Salud Carlos III Hospital de Sant Pau Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine Institut de Recerca Sant Pau Broad Institute Indiana University School of Medicine Indiana University – Purdue University Indianapolis Rutgers, The State University of New Jersey Centre Hospitalier Universitaire Sainte-Justine Université de Montréal Erasmus MC University of Dundee Genomics (United Kingdom)Stanford University University of Florida University of North Carolina at Chapel Hill University of Helsinki Helsinki University Hospital Institute for Molecular Medicine Finland Folkhälsans Forskningscentrum Boston Children's Hospital Boston Children's Museum University of Eastern Finland Kuopio University Hospital The Queen's Medical Research Institute University of Edinburgh University of Pittsburgh Zuyderland Medisch Centrum University of Chicago Deutsches Diabetes-Zentrum e.V.German Center for Diabetes Research Heinrich Heine University Düsseldorf VA Eastern Colorado Health Care System University of Colorado Denver Slovak Academy of Sciences Institute of Experimental Endocrinology of the Slovak Academy of Sciences University of Bergen Haukeland University Hospital Eastern Health Monash University Baylor College of Medicine Children's Nutrition Research Center at Baylor College of Medicine Texas Children's Hospital University of Manitoba Inserm Sorbonne Université Nutrition et obésité : approches systémiques Assistance Publique – Hôpitaux de Paris King's College London University of Colorado Anschutz Riley Hospital for Children Richard L. Roudebush VA Medical Center Institut d'Investigació Biomèdica de Girona Hospital Universitari de Girona Doctor Josep Trueta Northwell Health Feinstein Institute for Medical Research University of California, San Francisco Cedars-Sinai Medical Center The University of Adelaide University of South Dakota Sanford Children's Specialty Clinic Colorado School of Public Health Royal Devon & Exeter NHS Foundation Trust Children's Hospital of Pittsburgh Benaroya Research Institute Northwestern University University of Virginia University of Minnesota KU Leuven University of Glasgow University of Southern Denmark Rigshospitalet Brigham and Women's Hospital National Health Research Institutes Taipei Veterans General Hospital Taichung Veterans General Hospital Steno Diabetes Centers Aarhus University Hospital University Children's Hospital Tübingen Institute of Diabetes Research Newcastle University Hôpital Saint-Antoine The Royal Melbourne Hospital The University of Melbourne Deakin University Walter and Eliza Hall Institute of Medical Research Guy's and St Thomas' NHS Foundation Trust Hôpital Necker-Enfants Malades Institut Cochin University of Maryland, Baltimore Dartmouth College Pitié-Salpêtrière Hospital National University of Singapore Kaiser Permanente National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases Lurie Children's Hospital American Diabetes Association University of Antwerp University of Gondar University of Colorado Boulder Trinity College Dublin Wexford General Hospital Endeavor Health Sanford Research University of Washington Université de Sherbrooke Harvard Pilgrim Health Care Seoul National University Hospital Icahn School of Medicine at Mount Sinai Imperial College Healthcare NHS Trust Imperial College London Dr. Mohan's Diabetes Specialities Centre University of Auckland Counties Manukau District Health Board Auckland District Health Board Oxford BioMedica (United Kingdom)Wellcome/MRC Institute of Metabolic Science University of Michigan Translational Research Institute for Metabolism and Diabetes Pennington Biomedical Research Center Institute of Genetics and Cancer Yale University The University of Sydney Royal Prince Alfred Hospital Kaiser Permanente Center for Health Research Düsseldorf University Hospital Aarhus University

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Sujets associés

Cardiovascular Disease and AdiposityCardiovascular Function and Risk FactorsCardiac Imaging and Diagnostics

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