Effects of EPs 7630 on Illness Absence from Childcare or School due to Acute Bronchitis—A Meta-analysis
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Le résumé fourni par la source
Abstract Objective In the pediatric population, acute bronchitis (AB) is a leading cause of illness absence from childcare, school, or apprenticeship. We report a meta-analysis of double-blind, randomized trials with children and adolescents with AB (aged 1–18 years), who were treated with Pelargonium extract EPs 7630 or placebo for 7 days. Methods The average number of days absent from childcare, school, or apprenticeship due to illness and the proportion of patients still unable to return to their normal activities at treatment end were assessed. Results Literature search identified two eligible trials with a total of 420 patients. Illness absence was reported for all but two patients under placebo at baseline and for 46.7% (EPs 7630) and 85.0% (placebo) of patients at day 7. Meta-analysis risk ratio for absence at day 7 was 0.55 (95% confidence interval: 0.47, 0.64) for all patients, 0.59 (0.46, 0.76) for children younger than 6 years, and 0.53 (0.44, 0.64) for participants aged 6 to 18 years, all favoring EPs 7630. Compared with placebo, average time until return to normal activities was reduced by EPs 7630 by 1.51 (1.16, 1.86) days for all subjects, by 1.50 (0.92, 20.7) days for those younger than 6 years, and by 1.54 (1.11, 1.97) days for those 6 to 18 years of age (p < 0.001 favoring EPs 7630 for all treatment group comparisons shown). Conclusion For children and adolescents with AB, meta-analysis shows that EPs 7630 treatment for 7 days significantly reduces the average time of illness absence and significantly increases the proportion of patients able to return to normal activities within 1 week.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effects of EPs 7630 on Illness Absence from Childcare or School due to Acute Bronchitis—A Meta-analysis
- Date Crossref
- 12/01/2024
- Éditeur
- Mathematical Modelling and Numerical Simulation with Applications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Karl Landsteiner University of Health Sciences Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Dr Willmar Schwabe (Germany) pays non établi dans la noticeEntreprise
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University of Cologne Institute of Medical Statistics pays non établi dans la noticeUniversité ou école supérieure
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Evangelisches Krankenhaus Hamm pays non établi dans la noticeÉtablissement de santé
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Pomeranian Medical University pays non établi dans la noticeUniversité ou école supérieure
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Dr. Willmar Schwabe GmbH & Co. KG Research and Development pays non établi dans la noticeEntreprise
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Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Faculty of Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Pediatrics — Karl Landsteiner University of Health Sciences, Dr Willmar Schwabe (Germany) et Institute of Medical Statistics — University of Cologne, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.