Abstract 17282: Ninety-Day Thrombotic Events in Patients With COVID-19, Association With Vaccination Status, and Changes Over Time: The Corona-VTE Network Study
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Le résumé fourni par la source
Background: Venous thromboembolism (VTE) and arterial thrombosis are among serious complications of COVID-19 in the early post-infection period. Data are less consistent about subsequent risk during convalescence, the association between vaccination status and COVID-19-assocaited thrombosis, or how the event rates may have changed over time. Methods: In this multicenter study, adult patients who received inpatient or outpatient care for confirmed COVID-19 at Mass General-Brigham health system, Beth Israel Deaconess Medical Center, Anne Arundel Medical Center, University of Virginia Medical Center, University of Colorado Health System, and Thomas Jefferson University Health System were included, with Brigham and Women’s Hospital serving as the coordinating center. Data were entered into a centralized database. Thrombotic events were adjudicated by independent physicians. Outcomes were assessed at 90-day follow-up. Findings were pre-specified to be assessed separately for hospitalized patients with COVID-19 vs outpatients. Results: The study included 9,932 patients (03/2020-06/2022, age: 54.8 ± 19.9 years; 55.7% female). In hospitalized patients, the 90-day cumulative incidence of VTE (n = 269) was 6.4% (95% CI: 5.6-7.2%). Respective 90-day event rates for arterial thrombosis (n = 98) were 2.3 % (95% CI: 1.8-2.9%). Event rates were lower for outpatients (Figure, Panel A). Ninety-day cumulative incidence of VTE and arterial thrombosis based on history of vaccination (restricted to cohort from 12/14/2020 onward) are presented in Panel B. The change in VTE and in arterial thrombotic events over time is represented in Figure, Panel C. Conclusions: In this multicenter study, 90-day adjudicated thrombotic events were important complications for hospitalized patients with COVID-19, while the event rates were very low among outpatients. Association between vaccination status and outcomes and trends over time require further investigation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Abstract 17282: Ninety-Day Thrombotic Events in Patients With COVID-19, Association With Vaccination Status, and Changes Over Time: The Corona-VTE Network Study
- Date Crossref
- 07/11/2023
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Brigham and Women's Hospital pays non établi dans la noticeÉtablissement de santé
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Cambia pays non établi dans la noticeOrganisation à but non lucratif
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Bruce Technologies (United States) pays non établi dans la noticeEntreprise
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Thomas Jefferson University pays non établi dans la noticeUniversité ou école supérieure
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Philadelphia University pays non établi dans la noticeUniversité ou école supérieure
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Charlottesville Medical Research pays non établi dans la noticeÉtablissement de santé
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Bühler (United Kingdom) pays non établi dans la noticeEntreprise
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University of Colorado Denver pays non établi dans la noticeUniversité ou école supérieure
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St. Gregory's University pays non établi dans la noticeUniversité ou école supérieure
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Brigham and Womens Hosp pays non établi dans la noticeInstitution
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Bellerose pays non établi dans la noticeInstitution
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Antoine Bejjani Brigham and Women's Hosp pays non établi dans la noticeInstitution
Brigham and Women's Hospital, Cambia et Bruce Technologies (United States), avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.