Sirus Jesudasen

Tiling 16S rRNA Gene Amplicon Sequencing Identifies Bacterial Species Soon After Lung Transplant That Predict Acute Cellular Rejection

Sirus Jesudasen, Dastan Haghnazari, Minsik Kim, Laura Brenner et autres

BACKGROUND: The lung bacteriome is increasingly recognized as consequential in lung transplant (LTx) outcomes; however, most studies are limited to genus-level taxonomic resolution. METHODS: LTx recipients at Ohio State University Wexner Medical Center were recruited for this study. By protocol, bronchoscopy is …

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First, do NOHARM: towards clinically safe large language models.

David Wu, Fateme Nateghi Haredasht, Saloni Kumar Maharaj, Priyank Jain et autres

Large language models (LLMs) are routinely used by physicians and patients for medical advice, yet their clinical safety profiles remain poorly characterized. We present NOHARM (Numerous Options Harm Assessment for Risk in Medicine), a benchmark using 100 real primary care-to-specialist consultation cases …

Adjudicated Cardiovascular Events in Patients With COVID‐19: Association With Vaccination Status and Changes over Time

Behnood Bikdeli, Darsiya Krishnathasan, Antoine Bejjani, Candrika D. Khairani et autres

Background Patients with COVID‐19 are at risk of thrombotic and cardiovascular complications. Existing risk estimates derive from early COVID‐19 experiences. More recent event rates, temporal trends, and the association between vaccination status and cardiovascular outcomes remain unclear. Methods The CORONA‐VTE Network (COVID‐19 …

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Association between Active Cancer and Risk of Thrombotic and Cardiovascular Outcomes in Outpatients with COVID-19: A CORONA-VTE Network Analysis

Bridget McGonagle, Christie Greason, Darsiya Krishnathasan, Giovanni Scimeca et autres

Coronavirus disease 2019 (COVID-19) and active cancer are each independently associated with excess risk of thrombotic and cardiovascular events. However, data are limited regarding the risk of these events in outpatients with active cancer and concomitant COVID-19. This study aimed to retrospectively …

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Nasal Microbiome Profiles Are Associated With Prospective Respiratory Viral Infection Risk in School-aged Children

C.-Y. Huang, Dastan Haghnazari, Abiyad Baig, M. Kim et autres

Abstract RATIONALE: Emerging research shows the nasal microbiome has the potential to change susceptibility to respiratory infections. In our study, we investigated whether the nasal microbiome in children with asthma is associated with prospective risk of viral infection. METHODS: In a prospective …

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Species Level Identification Via Tiling 16s rRNA Gene Amplicon Sequencing for Microbiome Characterization of Bronchoalveolar Lavage Fluid in Lung Transplant Patients: A Proof-of-Concept Study

Sirus Jesudasen, D. Haghnazari, Laura Brenner, J. Rosenheck et autres

Abstract RATIONALE: Microbiome sequencing of respiratory samples is challenging due to low bacterial biomass and prevalent “contaminant” human DNA. Pulmonary microbiome analyses typically focus on amplicon sequencing of a 16S rRNA gene region and are thus typically limited to genus-level taxonomic classification. …

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A Tropical Disease in the Snow: Leptospirosis in a Healthy New Englander

Erin P. Sundel, Hannah Kerman, Sirus Jesudasen, Margaret M. Hayes

Abstract Leptospirosis is a spirochete infection frequently diagnosed in tropical areas. In rare cases, leptospirosis progresses to an icteric phase (Weil's disease) which includes pulmonary injury, renal failure, and can be fatal if not promptly detected. We present a 71-year-old man without …

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Lung's New Lease: Kaposi's Sarcoma After Lung Transplant Responsive to Everolimus

Sirus Jesudasen, Rene S. Bermea, Jacqueline Mojica, S. Lands et autres

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Exploration of Microbial Serostatus and Leukocyte Telomere Lengths in Patients Referred for Lung Transplantation

Sirus Jesudasen, S. Mervis, Shuang Zhao, B.C. Keller

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Characterizing Telomere Lengths in Leukocyte Subsets of Lung Transplant Referrals

Sirus Jesudasen, S. Mervis, Shiqi Zhao, Brian C. Keller

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Navigating Dual Battles: Lung Transplant Success Amidst Incidental Advanced Cancer on Explant

Sirus Jesudasen, B. Keller, Eriberto Michel, S. Nandavaram

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When the Lungs Breathe Trouble: Ureaplasma Infection Causing Hyperammonemia Syndrome, Followed by HSV Pneumonitis, After Bilateral Lung Transplant

Sirus Jesudasen, Rene S. Bermea, Isabel P. Neuringer, S. Nandavaram et autres