Protective factors for children with autism spectrum disorder during COVID-19-related strict lockdowns: a Shanghai autism early developmental cohort study
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Le résumé fourni par la source
Abstract Background COVID-19 lockdowns increased the risk of mental health problems, especially for children with autism spectrum disorder (ASD). However, despite its importance, little is known about the protective factors for ASD children during the lockdowns. Methods Based on the Shanghai Autism Early Developmental Cohort, 188 ASD children with two visits before and after the strict Omicron lockdown were included; 85 children were lockdown-free, while 52 and 51 children were under the longer and the shorter durations of strict lockdown, respectively. We tested the association of the lockdown group with the clinical improvement and also the modulation effects of parent/family-related factors on this association by linear regression/mixed-effect models. Within the social brain structures, we examined the voxel-wise interaction between the grey matter volume and the identified modulation effects. Results Compared with the lockdown-free group, the ASD children experienced the longer duration of strict lockdown had less clinical improvement (β = 0.49, 95% confidence interval (CI) [0.19–0.79], p = 0.001) and this difference was greatest for social cognition (2.62 [0.94–4.30], p = 0.002). We found that this association was modulated by parental agreeableness in a protective way (−0.11 [−0.17 to −0.05], p = 0.002). This protective effect was enhanced in the ASD children with larger grey matter volumes in the brain's mentalizing network, including the temporal pole, the medial superior frontal gyrus, and the superior temporal gyrus. Conclusions This longitudinal neuroimaging cohort study identified that the parental agreeableness interacting with the ASD children's social brain development reduced the negative impact on clinical symptoms during the strict lockdown.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Protective factors for children with autism spectrum disorder during COVID-19-related strict lockdowns: a Shanghai autism early developmental cohort study
- Date Crossref
- 24/11/2023
- Éditeur
- Cambridge University Press (CUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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XinHua Hospital pays non établi dans la noticeÉtablissement de santé
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Shanghai Children's Hospital pays non établi dans la noticeÉtablissement de santé
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University of Liège Psychology and Neuroscience of Cognition Research Unit pays non établi dans la noticeUniversité ou école supérieure
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Kunming Medical University Center for Experimental Studies and Research pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Kunming Medical University pays non établi dans la noticeÉtablissement de santé
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Shanghai Jiao Tong University Department of Developmental and Behavioral Pediatric and Child Primary Care pays non établi dans la noticeUniversité ou école supérieure
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Shanghai Mental Health Center pays non établi dans la noticeÉtablissement de santé
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Shanghai Key Laboratory of Psychotic Disorders pays non établi dans la noticeStructure de recherche
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Central South University Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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Second Xiangya Hospital of Central South University pays non établi dans la noticeÉtablissement de santé
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Fudan University Psychiatry Department of Huashan Hospital pays non établi dans la noticeUniversité ou école supérieure
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Huashan Hospital pays non établi dans la noticeÉtablissement de santé
XinHua Hospital, Shanghai Children's Hospital et Psychology and Neuroscience of Cognition Research Unit — University of Liège, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.