The evidence-based role of catecholaminergic PET tracers in Neuroblastoma. A systematic review and a head-to-head comparison with mIBG scintigraphy
Rattachement africain : it, ch, il, gb, dk, nl, fr, de, us, es, ca, pt. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Background Molecular imaging is pivotal in staging and response assessment of children with neuroblastoma (NB). [123I]-metaiodobenzylguanidine (mIBG) is the standard imaging method; however, it is characterised by low spatial resolution, time-consuming acquisition procedures and difficult interpretation. Many PET catecholaminergic radiotracers have been proposed as a replacement for [123I]-mIBG, however they have not yet made it into clinical practice. We aimed to review the available literature comparing head-to-head [123I]-mIBG with the most common PET catecholaminergic radiopharmaceuticals. Methods We searched the PubMed database for studies performing a head-to-head comparison between [123I]-mIBG and PET radiopharmaceuticals including meta-hydroxyephedrine ([11C]C-HED), 18F-18F-3,4-dihydroxyphenylalanine ([18F]DOPA) [124I]mIBG and Meta-[18F]fluorobenzylguanidine ([18F]mFBG). Review articles, preclinical studies, small case series (< 5 subjects), case reports, and articles not in English were excluded. From each study, the following characteristics were extracted: bibliographic information, technical parameters, and the sensitivity of the procedure according to a patient-based analysis (PBA) and a lesion-based analysis (LBA). Results Ten studies were selected: two regarding [11C]C-HED, four [18F]DOPA, one [124I]mIBG, and three [18F]mFBG. These studies included 181 patients (range 5–46). For the PBA, the superiority of the PET method was reported in two out of ten studies (both using [18F]DOPA). For LBA, PET detected significantly more lesions than scintigraphy in seven out of ten studies. Conclusions PET/CT using catecholaminergic tracers shows superior diagnostic performance than mIBG scintigraphy. However, it is still unknown if such superiority can influence clinical decision-making. Nonetheless, the PET examination appears promising for clinical practice as it offers faster image acquisition, less need for sedation, and a single-day examination.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The evidence-based role of catecholaminergic PET tracers in Neuroblastoma. A systematic review and a head-to-head comparison with mIBG scintigraphy
- Date Crossref
- 14/11/2023
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Ente Ospedaliero Ospedali Galliera pays non établi dans la noticeÉtablissement de santé
-
Ente Ospedaliero Cantonale pays non établi dans la noticeInstitution
-
Istituto Imaging della Svizzera Italiana pays non établi dans la noticeÉtablissement de santé
-
Università della Svizzera italiana pays non établi dans la noticeUniversité ou école supérieure
-
University of Lausanne pays non établi dans la noticeUniversité ou école supérieure
-
Tel Aviv University Department of Nuclear Medicine pays non établi dans la noticeUniversité ou école supérieure
-
Schneider Children's Medical Center pays non établi dans la noticeÉtablissement de santé
-
Great Ormond Street Hospital for Children NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
-
University of Copenhagen Rigshospitalet pays non établi dans la noticeUniversité ou école supérieure
-
Rigshospitalet pays non établi dans la noticeÉtablissement de santé
-
University Medical Center Utrecht Department of Nuclear Medicine and Radiology pays non établi dans la noticeÉtablissement de santé
-
Institut Curie Department of Nuclear Medicine pays non établi dans la noticeOrganisation à but non lucratif
Ente Ospedaliero Ospedali Galliera, Ente Ospedaliero Cantonale et Istituto Imaging della Svizzera Italiana, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.