Accès ouvert déclaré
2023
article
The Impact of Ferric Derisomaltose on Cardiovascular and Noncardiovascular Events in Patients With Anemia, Iron Deficiency, and Heart Failure With Reduced Ejection Fraction
Robin Ray, Ian Ford, John G.F. Cleland, Fraser J Graham, Fozia Ahmed, Abdallah Al‐Mohammad, Peter J. Cowburn, Chris Critoph, Philip A. Kalra, Rebecca Lane, Andrew Ludman, Pierpaolo Pellicori, Mark C. Petrie, Michelle M. Robertson, Alison Seed, Iain Squire, Paul R. Kalra, Elena Cowan, Serena Howe, Charlotte Turner, Rosalynn Austin, Rebeca Lane, Paula Rogers, Paul Foley, Badri Chandrasekaran, E Fraile, Lynsey Kyeremeh, Mark Petrie, Lorraine McGregor, Joanna Osmanska, Ninian N. Lang, Faheem Ahmad, Jude Fisher, Christina Summersgill, Katarzyna Adeniji, Rajkumar Chinnadurai, Lisa Massimo, Clare S. Hardman, Daisy Sykes, Sarah Frank, Simon Smith, Alan G. Japp, Mohamed Anwar, Beth Whittington, Vennessa Sookhoo, Janet Middle, Kay Housley, Andrew L. Clark, Jeanne Bulemfu, Christopher Critoph, Victor Chong, Stephen J. Wood, Benjamin R. Szwejkowski, Chim C. Lang, Jackie Duff, Susan M. MacDonald, Rebekah Schiff, Thuraia Nageh, Swapna Kunhunny, Roy S. Gardner, Marion McAdam, Elizabeth McPherson, Prithwish Banerjee, Eleanor Sear, Nigel Edwards, Jason Glover, Clare Murphy, Justin Cooke, Charles Spencer, Mark L. Francis, Iain Matthews, Hayley McKie, Andrew Marshall, Janet Large, Jenny Stratford, Piers Clifford, Sara Tavares, Christopher J. Boos, Philip J. Keeling, Debbie Hughes, Aaron Wong, Deborah J. Jones, Alex James, Rhys Williams, Stephen J Leslie, Jim Finlayson, Andrew Hannah, Philip Campbell, John Walsh, Jane Quinn, Callum Chapman, Susan Piper, Preeti Gupta, Victor Sim, Lucy Knibbs, Kristopher Lyons, Lana Dixon, Colin J. Petrie, Yuk-ki Wong, Catherine Labinjoh, Simon Duckett, Ian J. Massey, Henry Oluwasefunmi Savage, Sofia Matias, Jonaifah Ramirez, Charlotte Manisty, Ifza Hussain, Rajiv Sankaranarayanan, Gershan Davis, Samuel McClure, John Baxter, Eleanor Wicks, Jolanta Sobolewska, Jerry D. Murphy, Ahmed Elzayat, Alastair Cooke, Jay Wright, Simon G. Williams, Amal Muthumala, Parminder S Chaggar, Mandie Welch, Sudantha Bulugahapitiya, Thomas Jackson, Tapesh Pakrashi, Ameet Bakhai, Reto Gamma, Susan Ellery, Geraint H. Jenkins, Angus K. Nightingale, Elizabeth Thomson, Michele Robertson, Nicola Greenlaw, Kirsty Wetherall, Ross Clarke, Sharon Kean, A. C. Stevenson, Robbie S. Wilson, Sarah C. Boyle, John B. McHugh, Lisa Hall, Joanne Woollard, Claire Brunton, Eleanor Dinnett, Amanda Reid, Jill Nicholls, Anna Cunnington, Elizabeth Douglas, Margaret Fegen, Marc V. Jones, Sheila McGowan, Barbara Ross, Pamela Sandu, Pamela Surtees, Debra Stuart
5Citations signalées — pas une note de qualité
17Institutions déclarées
1Pays d’affiliation déclarés
Résumé fourni par la source
BACKGROUND: In some countries, intravenous ferric derisomaltose (FDI) is only licensed for treating iron deficiency with anemia. Accordingly, we investigated the effects of intravenous FDI in a subgroup of patients with anemia in the IRONMAN (Effectiveness of Intravenous (IV) Iron Treatment Versus Standard Care in Patients With Heart Failure and Iron Deficiency) trial. METHOD AND RESULTS: IRONMAN enrolled patients with heart failure, a left ventricular ejection fraction of ≤45%, and iron deficiency (ferritin <100 µg/L or transferrin saturation of <20%), 771 (68%) of whom had anemia (hemoglobin <12 g/dL for women and <13 g/dL for men). Patients were randomized, open label, to FDI (n = 397) or usual care (n = 374) and followed for a median of 2.6 years. The primary end point, recurrent hospitalization for heart failure and cardiovascular death, occurred less frequently for those assigned to FDI (rate ratio 0.78, 95% confidence interval 0.61-1.01; P = .063). First event analysis for cardiovascular death or hospitalization for heart failure, less affected by the coronavirus disease 2019 pandemic, gave similar results (hazard ratio 0.77, 95% confidence interval 0.62-0.96; P = .022). Patients randomized to FDI reported a better Minnesota Living with Heart Failure quality of life, for overall (P = .013) and physical domain (P = .00093) scores at 4 months. CONCLUSIONS: In patients with iron deficiency anemia and heart failure with reduced left ventricular ejection fraction, intravenous FDI improves quality of life and may decrease cardiovascular events.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The Impact of Ferric Derisomaltose on Cardiovascular and Noncardiovascular Events in Patients With Anemia, Iron Deficiency, and Heart Failure With Reduced Ejection Fraction
- Date Crossref
- 01/05/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Iron Metabolism and DisordersErythropoietin and Anemia TreatmentHemoglobinopathies and Related Disorders