Silica-based silver nanocomposite 80S/Ag as Aggregatibacter actinomycetemcomitans inhibitor and its in vitro bioactivity
Rattachement africain : tw, jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
As a commonly-found pathogen in periodontal disease, Aggregatibacter actinomycetemcomitans has been reported with several antibiotic resistance. Thus, to develop an alternative and protective therapy for A. actinomycetemcomitans infections is urgently needed in dentistry. In this study, we sought to synthesize a silica-based material to deliver silver nanoparticles for antibacterial purposes. Also, the bioactivities were examined via analyzing the formation of hydroxyapatite. The 80S/Ag powders were prepared by the evaporation-induced self-assembly method, with Si, Ca, P, and Ag composition ratios of 80, 15, 5, and 1/5/10 (mole percentage), respectively. The nitrogen adsorption-desorption isotherms, transmission electron microscope, selected area electron diffraction, and Fourier transform infrared spectroscopy were conducted for textural analyses. The disk diffusion test was carried out against A. actinomycetemcomitans strain ATCC 29523. In vitro bioactivity assessment involved soaking 80S/Ag membrane powders in acellular simulated body fluid. We successfully developed a material consisting of Si, Ca, P, and Ag, namely the 80S/Ag. In the antibacterial testing, the 80S/Ag demonstrated antibacterial activity against the commonly-found oral pathogen, A. actinomycetemcomitans, with a long-lasting effect for 168h. The formation of hydroxyapatite in simulated body fluid highlighted the characteristic of dentine remineralization for the 80S/Ag. The increased pH values after immersion in simulated body fluid would help neutralize the acidic oral environment. Our results indicate that 80S/Ag possesses remarkable antibacterial properties, hydroxyapatite formation, and increased pH values after immersion in simulated body fluid, supporting the potential therapeutic application of 80S/Ag for treating periodontal disease.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Silica-based silver nanocomposite 80S/Ag as Aggregatibacter actinomycetemcomitans inhibitor and its in vitro bioactivity
- Date Crossref
- 01/01/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kaohsiung Medical University Department of Clinical Dentistry pays non établi dans la noticeUniversité ou école supérieure
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Kaohsiung Medical University Chung-Ho Memorial Hospital pays non établi dans la noticeÉtablissement de santé
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Kaohsiung Municipal Ta-Tung Hospital Department of Dentistry pays non établi dans la noticeÉtablissement de santé
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Waseda University Research Institute for Science and Engineering pays non établi dans la noticeUniversité ou école supérieure
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I-Shou University Department of Medical Laboratory Science pays non établi dans la noticeUniversité ou école supérieure
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School of Dentistry pays non établi dans la noticeUniversité ou école supérieure
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School of Education pays non établi dans la noticeUniversité ou école supérieure
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College of Pharmacy Department of Fragrance and Cosmetic Science pays non établi dans la noticeUniversité ou école supérieure
Department of Clinical Dentistry — Kaohsiung Medical University, Kaohsiung Medical University Chung-Ho Memorial Hospital et Department of Dentistry — Kaohsiung Municipal Ta-Tung Hospital, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.