Resveratrol: a potential medication for the prevention and treatment of varicella zoster virus-induced ischemic stroke
Rattachement africain : cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Infection rate of varicella zoster virus (VZV) is 95% in humans, and VZV infection is strongly associated with ischemic stroke (IS). However, the underlying molecular mechanisms of VZV-induced IS are still unclear, and there are no effective agents to treat and prevent VZV-induced IS. OBJECTIVE: By integrating bioinformatics, this study explored the interactions between VZV and IS and potential medication to treat and prevent VZV-induced IS. METHODS: In this study, the VZV and IS datasets from the GEO database were used to specify the common genes. Then, bioinformatics analysis including Gene Ontology, Kyoto Encyclopedia Genes Genomes and Protein-Protein Interaction network analysis was performed. Further, the hub genes, transcription factor (TF) gene interactions, TF-miRNA co-regulatory network and potential drug were obtained. Finally, validation was performed using molecular docking and molecular dynamics simulations. RESULTS: The potential molecular mechanisms of VZV-induced IS were studied using multiple bioinformatics tools. Ten hub genes were COL1A2, DCN, PDGFRB, ACTA2, etc. TF genes and miRNAs included JUN, FOS, CREB, BRCA1, PPARG, STAT3, miR-29, etc. A series of mechanism may be involved, such as inflammation, oxidative stress, blood-brain barrier disruption, foam cell generation and among others. Finally, we proposed resveratrol as a potential therapeutic medicine for the prevention and treatment of VZV-induced IS. Molecular docking and molecular dynamics results showed that resveratrol and hub genes exhibited strong binding score. CONCLUSIONS: Resveratrol could be an alternative for the prevention and treatment of VZV-IS. More in vivo and in vitro studies are needed in the future to fully explore the molecular mechanisms between VZV and IS and for medication development.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Resveratrol: a potential medication for the prevention and treatment of varicella zoster virus-induced ischemic stroke
- Date Crossref
- 05/10/2023
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Jilin University Department of Neurovascular Surgery pays non établi dans la noticeUniversité ou école supérieure
-
Changchun University of Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
-
First Hospital of Jilin University pays non établi dans la noticeÉtablissement de santé
-
Union Hospital pays non établi dans la noticeÉtablissement de santé
-
Jilin Jianzhu University pays non établi dans la noticeUniversité ou école supérieure
-
College of Traditional Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
-
School of Public Health pays non établi dans la noticeUniversité ou école supérieure
-
Ltd Jilin Connell Pharmaceutical Co. pays non établi dans la noticeEntreprise
Department of Neurovascular Surgery — Jilin University, Changchun University of Chinese Medicine et First Hospital of Jilin University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.