Hao Chen

PRRSV-induced glucose-6-phosphate transporter promotes viral replication by suppressing type I interferon transcription

Xibao Shi, Keqi Wang, Yuyao Wang, Siyu Peng et autres

cn (code pays fourni par la source)

The gut methanotroph Methylocystis intestini modulates intestinal peristalsis and fat metabolism via reducing methane levels

Yiming Zhao, Hao Chen, Jing Huang, Ludmila Chistoserdova et autres

Methane, a predominant component of human intestinal gas, has been reported to be associated with a reduction in intestinal transit speed, as well as correlations with elevated body mass index. While the gut methanogenic archaea that produce this gas have been studied, …

cn, us (code pays fourni par la source)

ManualVLA: A Unified VLA Model for Chain-of-Thought Manual Generation and Robotic Manipulation

Chenyang Gu, Jiaming Liu, Hao Chen, Runzhong Huang et autres

Vision-Language-Action (VLA) models have recently emerged, demonstrating strong generalization in robotic scene understanding and manipulation. However, when confronted with long-horizon tasks that require defined goal states, such as LEGO assembly or object rearrangement, existing VLA models still face challenges in coordinating high-level …

Automatic processing and real-time analysis system for deep brain electrical signals based on sensing-enabled DBS

Lingxiao Guan, Fan Yu, Guokun Zhang, Yichen Zheng et autres

脑深部电刺激（Deep Brain Stimulation, DBS）作为一种成熟的神经调控技术，已成为帕金森病、强迫症等神经精神疾病的重要治疗手段。近年来，具备感知功能的DBS设备通过在输出刺激的同时记录局部场电位（Local Field Potential, LFP），实现了从单向“写脑”到双向“读脑-写脑”的重要突破，推动了双向闭环脑机融合的发展。然而，基于可感知DBS的局部场电位信号研究面临两个核心科学问题：一是信噪分离难题，即在全植入环境下如何从所记录的信号中有效分离目标生理信号与噪声；二是实时性与安全性的协同优化，即如何在脑机数据安全交互的同时，进行实时精准分析及输出调节。 针对上述问题，本研究提出了系统化的基于可感知DBS的脑深部电信号处理与分析方法。针对噪声伪迹的复杂性，本研究设计了基于双分支深度神经网络的自动识别算法，在验证集中取得93.9%的识别准确率；在跨患者、跨标注者的测试集上识别准确率达86.0%；并基于此构建了从预处理到特征提取的自动分析流程。针对实时性及安全性问题，本研究提出了基于安全协议的实时信号传输与在线处理方法，信号传输的平均延迟增量仅1.32±0.37 ms。基于此，本研究进一步集成了NERCN神经信号研究平台（NERCN NeuroSignal Research，NNSR），实现了对基于可感知DBS采集的深脑信号从离线分析到在线实时传输处理的全链路技术支持。验证表明，本研究能够在复杂环境下识别深脑神经活动特征并支持实时分析，为神经调控机制探索和疗法创新提供了可靠技术支撑。

3D bioprinting using PEG-based extracellular matrix drives extravillous trophoblast differentiation in organoids

Claire Richards, Hao Chen, Matthew B. O’Rourke, Matthew Paul Padula et autres

au (code pays fourni par la source)

Enantiopure Dual-Helical Covalent Organic Framework Nanotubes Mediated by Supramolecular Assembly

Wenda Li, Hengyue Xu, Hongyi Zhang, Hao Chen et autres

Despite significant advancements in designing covalent organic frameworks (COFs), the directed engineering of them with mesoscopic chirality remains challenging due to the dynamic equilibrium between crystallization kinetics and intermolecular interactions. Herein, we propose a biomimetic chiral supramolecular assembly-mediated (CSAM) strategy for the …

us, sk, cn (code pays fourni par la source)

Nuclear factor IX could facilitate porcine reproductive and respiratory syndrome virus (PRRSV) replication and suppresses retinoic acid-inducible gene I (RIG-I) and toll-like receptor 3 (TLR-3)-mediated type I interferon transcription

Xibao Shi, Yuqi Xing, Hao Chen, Keqi Wang et autres

cn (code pays fourni par la source)

Exposure to harmful algal blooms and socio-demographic patterns: Evidence from six decades of analysis in Florida, USA

Hao Chen

cn, us (code pays fourni par la source)

Explain Any Pathological Concept: Discovering Hierarchical Explanations for Pathology Foundation Models

Shuting Xu, Junlin Hou, Hao Chen

cn, hk (code pays fourni par la source)

ELK1 modulates SF3B3 transcriptional activity to stimulate proliferation and inhibit apoptosis in gastric cancer through the activation of the MAPK pathway

Yaqing Zhang, Lei Gao, Lixin Liu, Hao Chen

Gastric cancer (GC) ranks as the fifth most common malignancy globally. Aberrant alternative splicing is implicated in tumorigenesis and progression. SF3B3, a key subunit of the spliceosome complex, is closely linked to alternative splicing dysfunction when its expression is dysregulated. This study …

cn (code pays fourni par la source)

Matrix directs trophoblast differentiation in a bioprinted organoid model of early placental development

Claire Richards, Hao Chen, Matthew B. O’Rourke, Grace Owen et autres

Trophoblast organoids can provide crucial insights into mechanisms of placentation, however their potential is limited by highly variable extracellular matrices unable to reflect in vivo tissues. Here, we present a bioprinted placental organoid model, generated using the first trimester trophoblast cell line, …

au (code pays fourni par la source)

Combating Counterfeit Drugs via Machine Learning-Enabled Array Screening of Multilayer Evolutionary Combinatorial Libraries

Huihai Li, Hao Chen, Weiwei Ni, Yutao Jin et autres

Counterfeit drugs are a global issue that has a serious impact on patient morbidity and mortality. Driven by nonspecific cross-reactivity, sensor arrays enable the concurrent discrimination of structurally related drug molecules. Nevertheless, rapidly generating sensor element libraries without a labor-intensive synthesis remains …

cn, us (code pays fourni par la source)