Accès ouvert déclaré 2023 review

Disease-modifying therapies and features linked to treatment response in type 1 diabetes prevention: a systematic review

Jamie L. Felton, Kurt Griffin, Richard A. Oram, Cate Speake, S. Alice Long, Suna Önengüt-Gümüşcü, Stephen S. Rich, Gabriela S. F. Monaco, Carmella Evans‐Molina, Linda A. DiMeglio, Heba M. Ismail, Andrea K. Steck, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, Stephen E. Gitelman, John M. Wentworth, María J. Redondo, Emily K. Sims, Deirdre K. Tobias, Jordi Merino, Abrar Ahmad, Catherine Aiken, Jamie L. Benham, Dhanasekaran Bodhini, Amy L. Clark, Kevin Colclough, Rosa Corcoy, Sara J. Cromer, Daisy Duan, Ellen C. Francis, Pieter Gillard, Véronique Gingras, Romy Gaillard, Eram Haider, Alice E. Hughes, Jennifer M. Iklé, Laura M. Jacobsen, Anna R. Kahkoska, Jarno L. T. Kettunen, Raymond J. Kreienkamp, Lee‐Ling Lim, Jonna M. E. Männistö, Robert Massey, Niamh‐Maire Mclennan, Rachel G. Miller, Mario Luca Morieri, Jasper Most, Rochelle N. Naylor, Bige Ozkan, Kashyap Patel, Scott J. Pilla, Katsiaryna Prystupa, Sridharan Raghavan, Mary R. Rooney, Martin Schön, Zhila Semnani‐Azad, Magdalena Sevilla-González, Pernille Svalastoga, Wubet Worku Takele, Claudia H.T. Tam, Anne Cathrine B. Thuesen, Mustafa Tosur, Amelia S. Wallace, Caroline C. Wang, Jessie J. Wong, Jennifer M. Yamamoto, Katherine Young, Chloé Amouyal, Mette K. Andersen, Maxine P. Bonham, Mingling Chen, Feifei Cheng, Tinashe Chikowore, Sian C. Chivers, Christoffer Clemmensen, Adem Y. Dawed, Aaron J. Deutsch, Laura T. Dickens, Monika Dudenhöffer‐Pfeifer, María Mercè Fernández-Balsells, Hugo Fitipaldi, Stephanie L. Fitzpatrick, Mark O. Goodarzi, Jessica A. Grieger, Marta Guasch‐Ferré, Nahal Habibi, Torben Hansen, Chuiguo Huang, Arianna Harris-Kawano, Benjamin Hoag, Angus G. Jones, Robert W. Koivula, Aaron Leong, Gloria K. W. Leung, Ingrid Libman, Kai Liu, William L. Lowe, Robert W. Morton, Ayesha A. Motala, James S. Pankow, Maleesa Pathirana, Sofia Pazmiño, Dianna Perez, John R. Petrie, Camille E. Powe, Alejandra Quinteros, Rashmi Jain, Debashree Ray, Mathias Ried‐Larsen, Zeb Saeed, Vanessa Santhakumar, Sarah Kanbour, Sudipa Sarkar, Denise Scholtens, Elizabeth Selvin, Wayne Huey‐Herng Sheu, Maggie A. Stanislawski, Nele Steenackers, Norbert Stefan, Julie Støy, Rachael W. Taylor, Sok Cin Tye, Gebresilasea Gendisha Ukke, Bart Van der Schueren, Camille Vatier, Wesley Hannah, Sara L. White, Gechang Yu, Yingchai Zhang, Shao J. Zhou, Jacques Beltrand, Michel Polak, Ingvild Aukrust, Elisa De Franco, Sarah E. Flanagan, Kristin A. Maloney, Andrew McGovern, Janne Molnes, Mariam Nakabuye, Pål R. Njølstad, Hugo Pomares‐Millan, Michele Provenzano, Cécile Saint‐Martin, Cuilin Zhang, Yeyi Zhu, Sungyoung Auh, Russell J. de Souza, Andrea J. Fawcett, Chandra Gruber, Eskedar Getie Mekonnen, Emily Mixter, Diana Sherifali, Robert H. Eckel, John J. Nolan, Louis H. Philipson, Rebecca J. Brown, Liana K. Billings, Kristen E. Boyle, Tina Costacou, John Dennis, José C. Florez, Anna L. Gloyn, Maria F. Gomez, Peter A. Gottlieb, Siri Atma W. Greeley, Andrew T. Hattersley, Irl B. Hirsch, Marie‐France Hivert, Korey K. Hood, Jami L. Josefson, Soo Heon Kwak, Lori M. Laffel, Siew Lim, Ruth J. F. Loos, Ronald C.W., Chantal Mathieu, Nestoras Mathioudakis, James B. Meigs, Shivani Misra, Viswanathan Mohan, Rinki Murphy, Richard A. Oram, Katharine R. Owen, Susan E. Ozanne, Ewan R. Pearson, Wei Perng, Toni I. Pollin, Rodica Pop‐Busui, Richard E. Pratley, Leanne M. Redman, Rebecca M. Reynolds, Robert K. Semple, Jennifer L. Sherr, Arianne Sweeting, Miriam S. Udler, Kimberly K. Vesco, Tina Vilsbøll, Róbert Wágner, Paul W. Franks

26Citations signalées — pas une note de qualité

163Institutions déclarées

26Pays d’affiliation déclarés

Résumé fourni par la source

BACKGROUND: Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Prevention efforts have focused on immune modulation and supporting beta cell health before or around diagnosis; however, heterogeneity in disease progression and therapy response has limited translation to clinical practice, highlighting the need for precision medicine approaches to T1D disease modification. METHODS: To understand the state of knowledge in this area, we performed a systematic review of randomized-controlled trials with ≥50 participants cataloged in PubMed or Embase from the past 25 years testing T1D disease-modifying therapies and/or identifying features linked to treatment response, analyzing bias using a Cochrane-risk-of-bias instrument. RESULTS: We identify and summarize 75 manuscripts, 15 describing 11 prevention trials for individuals with increased risk for T1D, and 60 describing treatments aimed at preventing beta cell loss at disease onset. Seventeen interventions, mostly immunotherapies, show benefit compared to placebo (only two prior to T1D onset). Fifty-seven studies employ precision analyses to assess features linked to treatment response. Age, beta cell function measures, and immune phenotypes are most frequently tested. However, analyses are typically not prespecified, with inconsistent methods of reporting, and tend to report positive findings. CONCLUSIONS: While the quality of prevention and intervention trials is overall high, the low quality of precision analyses makes it difficult to draw meaningful conclusions that inform clinical practice. To facilitate precision medicine approaches to T1D prevention, considerations for future precision studies include the incorporation of uniform outcome measures, reproducible biomarkers, and prespecified, fully powered precision analyses into future trial design.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Disease-modifying therapies and features linked to treatment response in type 1 diabetes prevention: a systematic review
Date Crossref: 05/10/2023
Éditeur: Springer Science and Business Media LLC
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.

Institutions déclarées

Indiana University School of Medicine Indiana University – Purdue University Indianapolis University of South Dakota Sanford Research University of Exeter Royal Devon & Exeter NHS Foundation Trust NIHR Exeter Clinical Research Facility Benaroya Research Institute University of Virginia Richard L. Roudebush VA Medical Center Sansum Diabetes Research Institute University of Colorado Anschutz Colorado School of Public Health Baylor College of Medicine University of California, San Francisco Diabetes Australia The Royal Melbourne Hospital The University of Melbourne Walter and Eliza Hall Institute of Medical Research Texas Children's Hospital Brigham and Women's Hospital Harvard University University of Copenhagen Novo Nordisk Foundation Massachusetts General Hospital Lund University University of Cambridge Rosie Hospital University of Calgary Madras Diabetes Research Foundation Cardinal Glennon Children’s Medical Center Saint Louis University Universitat Autònoma de Barcelona Instituto de Salud Carlos III Hospital de Sant Pau Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine Institut de Recerca Sant Pau Broad Institute Johns Hopkins University Johns Hopkins Medicine Rutgers, The State University of New Jersey Centre Hospitalier Universitaire Sainte-Justine Université de Montréal Erasmus MC University of Dundee Genomics (United Kingdom)Stanford University University of Florida University of North Carolina at Chapel Hill University of Helsinki Helsinki University Hospital Institute for Molecular Medicine Finland Folkhälsans Forskningscentrum Boston Children's Hospital Chinese University of Hong Kong University of Malaya Asia Diabetes Foundation Boston Children's Museum University of Eastern Finland Kuopio University Hospital The Queen's Medical Research Institute University of Edinburgh University of Pittsburgh University of Padua Zuyderland Medisch Centrum University of Chicago Deutsches Diabetes-Zentrum e.V.German Center for Diabetes Research Heinrich Heine University Düsseldorf VA Eastern Colorado Health Care System University of Colorado Denver Slovak Academy of Sciences Institute of Experimental Endocrinology of the Slovak Academy of Sciences University of Bergen Haukeland University Hospital Eastern Health Monash University Children's Nutrition Research Center at Baylor College of Medicine University of Manitoba Inserm Sorbonne Université Nutrition et obésité : approches systémiques Assistance Publique – Hôpitaux de Paris Dalian Medical University Second Affiliated Hospital of Chongqing Medical University Chongqing Medical University King's College London University of the Witwatersrand Institut d'Investigació Biomèdica de Girona Hospital Universitari de Girona Doctor Josep Trueta Northwell Health Feinstein Institute for Medical Research Cedars-Sinai Medical Center The University of Adelaide Sanford Children's Specialty Clinic University of Oxford Oxford Centre for Diabetes, Endocrinology and Metabolism Children's Hospital of Pittsburgh Northwestern University Population Health Research Institute McMaster University University of KwaZulu-Natal University of Minnesota KU Leuven University of Glasgow University of Southern Denmark Rigshospitalet National Health Research Institutes Taipei Veterans General Hospital Taichung Veterans General Hospital Steno Diabetes Centers Aarhus University Hospital University Children's Hospital Tübingen Institute of Diabetes Research Newcastle University Joslin Diabetes Center University Medical Center Groningen Hôpital Saint-Antoine Deakin University Guy's and St Thomas' NHS Foundation Trust Hôpital Necker-Enfants Malades Institut Cochin University of Maryland, Baltimore Dartmouth College Azienda USL di Bologna University of Bologna Pitié-Salpêtrière Hospital National University of Singapore Kaiser Permanente National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases Lurie Children's Hospital Impact American Diabetes Association University of Antwerp University of Gondar University of Colorado Boulder Trinity College Dublin Wexford General Hospital Endeavor Health Aarhus University University of Washington Université de Sherbrooke Harvard Pilgrim Health Care Seoul National University Hospital Icahn School of Medicine at Mount Sinai Imperial College Healthcare NHS Trust Imperial College London Dr. Mohan's Diabetes Specialities Centre University of Auckland Counties Manukau District Health Board Auckland District Health Board Wellcome/MRC Institute of Metabolic Science Oxford BioMedica (United Kingdom)University of Michigan Translational Research Institute for Metabolism and Diabetes Pennington Biomedical Research Center Institute of Genetics and Cancer Yale University The University of Sydney Royal Prince Alfred Hospital Kaiser Permanente Center for Health Research Düsseldorf University Hospital

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Sujets associés

Diabetes and associated disordersDiabetes Management and ResearchPancreatic function and diabetes

Lire en accès ouvert Consulter la publication primaire DOI