Accès ouvert déclaré 2023 review

Treatment effect heterogeneity following type 2 diabetes treatment with GLP1-receptor agonists and SGLT2-inhibitors: a systematic review

Katherine Young, Eram Haider McInnes, Robert Massey, Anna R. Kahkoska, Scott J. Pilla, Sridharan Raghavan, Maggie A. Stanislawski, Deirdre K. Tobias, Andrew McGovern, Adem Y. Dawed, Angus G. Jones, Ewan R. Pearson, John Dennis, Jordi Merino, Abrar Ahmad, Catherine Aiken, Jamie L. Benham, Dhanasekaran Bodhini, Amy L. Clark, Kevin Colclough, Rosa Corcoy, Sara J. Cromer, Daisy Duan, Jamie L. Felton, Ellen C. Francis, Pieter Gillard, Véronique Gingras, Romy Gaillard, Eram Haider, Alice E. Hughes, Jennifer M. Iklé, Laura M. Jacobsen, Jarno L. T. Kettunen, Raymond J. Kreienkamp, Lee‐Ling Lim, Jonna M. E. Männistö, Niamh‐Maire Mclennan, Rachel G. Miller, Mario Luca Morieri, Jasper Most, Rochelle N. Naylor, Bige Özkan, Kashyap Patel, Katsiaryna Prystupa, Sridaran Raghaven, Mary R. Rooney, Martin Schön, Zhila Semnani‐Azad, Magdalena Sevilla-González, Pernille Svalastoga, Wubet Worku Takele, Claudia H.T. Tam, Anne Cathrine B. Thuesen, Mustafa Tosur, Amelia S. Wallace, Caroline C. Wang, Jessie J. Wong, Jennifer M. Yamamoto, Chloé Amouyal, Mette K. Andersen, Maxine P. Bonham, Mingling Chen, Feifei Cheng, Tinashe Chikowore, Sian C. Chivers, Christoffer Clemmensen, Dana Dabelea, Aaron J. Deutsch, Laura T. Dickens, Linda A. DiMeglio, Monika Dudenhöffer‐Pfeifer, Carmella Evans‐Molina, María Mercè Fernández-Balsells, Hugo Fitipaldi, Stephanie L. Fitzpatrick, Stephen E. Gitelman, Mark O. Goodarzi, Jessica A. Grieger, Marta Guasch‐Ferré, Nahal Habibi, Torben Hansen, Chuiguo Huang, Arianna Harris-Kawano, Heba M. Ismail, Benjamin Hoag, Randi K. Johnson, Robert W. Koivula, Aaron Leong, Gloria K. W. Leung, Ingrid Libman, Kai Liu, S. Alice Long, William L. Lowe, Robert W. Morton, Ayesha A. Motala, Suna Önengüt-Gümüşcü, James S. Pankow, Maleesa Pathirana, Sofia Pazmiño, Dianna Perez, John R. Petrie, Camille E. Powe, Alejandra Quinteros, Rashmi Jain, Debashree Ray, Mathias Ried‐Larsen, Zeb Saeed, Vanessa Santhakumar, Sarah Kanbour, Sudipa Sarkar, Gabriela S. F. Monaco, Denise Scholtens, Elizabeth Selvin, Wayne Huey‐Herng Sheu, Cate Speake, Nele Steenackers, Andrea K. Steck, Norbert Stefan, Julie Støy, Rachael W. Taylor, Sok Cin Tye, Gebresilasea Gendisha Ukke, Marzhan Urazbayeva, Bart Van der Schueren, Camille Vatier, John M. Wentworth, Wesley Hannah, Sara L. White, Gechang Yu, Yingchai Zhang, Shao J. Zhou, Jacques Beltrand, Michel Polak, Ingvild Aukrust, Elisa De Franco, Sarah E. Flanagan, Kristin A. Maloney, Janne Molnes, Mariam Nakabuye, Pål R. Njølstad, Hugo Pomares‐Millan, Michele Provenzano, Cécile Saint‐Martin, Cuilin Zhang, Yeyi Zhu, Sungyoung Auh, Russell J. de Souza, Andrea J. Fawcett, Chandra Gruber, Eskedar Getie Mekonnen, Emily Mixter, Diana Sherifali, Robert H. Eckel, John J. Nolan, Louis H. Philipson, Rebecca J. Brown, Liana K. Billings, Kristen E. Boyle, Tina Costacou, José C. Florez, Anna L. Gloyn, Maria F. Gomez, Peter A. Gottlieb, Siri Atma W. Greeley, Kurt Griffin, Andrew T. Hattersley, Irl B. Hirsch, Marie‐France Hivert, Korey K. Hood, Jami L. Josefson, Soo Heon Kwak, Lori M. Laffel, Siew Lim, Ruth J. F. Loos, Ronald C.W., Chantal Mathieu, Nestoras Mathioudakis, James B. Meigs, Shivani Misra, Viswanathan Mohan, Rinki Murphy, Richard A. Oram, Katharine R. Owen, Susan E. Ozanne, Wei Perng, Toni I. Pollin, Rodica Pop‐Busui, Richard E. Pratley, Leanne M. Redman, María J. Redondo, Rebecca M. Reynolds, Robert K. Semple, Jennifer L. Sherr, Emily K. Sims, Arianne Sweeting, Miriam S. Udler, Kimberly K. Vesco, Tina Vilsbøll, Róbert Wágner, Stephen S. Rich, Paul W. Franks

42Citations signalées — pas une note de qualité

165Institutions déclarées

26Pays d’affiliation déclarés

Résumé fourni par la source

BACKGROUND: A precision medicine approach in type 2 diabetes requires the identification of clinical and biological features that are reproducibly associated with differences in clinical outcomes with specific anti-hyperglycaemic therapies. Robust evidence of such treatment effect heterogeneity could support more individualized clinical decisions on optimal type 2 diabetes therapy. METHODS: We performed a pre-registered systematic review of meta-analysis studies, randomized control trials, and observational studies evaluating clinical and biological features associated with heterogenous treatment effects for SGLT2-inhibitor and GLP1-receptor agonist therapies, considering glycaemic, cardiovascular, and renal outcomes. After screening 5,686 studies, we included 101 studies of SGLT2-inhibitors and 75 studies of GLP1-receptor agonists in the final systematic review. RESULTS: Here we show that the majority of included papers have methodological limitations precluding robust assessment of treatment effect heterogeneity. For SGLT2-inhibitors, multiple observational studies suggest lower renal function as a predictor of lesser glycaemic response, while markers of reduced insulin secretion predict lesser glycaemic response with GLP1-receptor agonists. For both therapies, multiple post-hoc analyses of randomized control trials (including trial meta-analysis) identify minimal clinically relevant treatment effect heterogeneity for cardiovascular and renal outcomes. CONCLUSIONS: Current evidence on treatment effect heterogeneity for SGLT2-inhibitor and GLP1-receptor agonist therapies is limited, likely reflecting the methodological limitations of published studies. Robust and appropriately powered studies are required to understand type 2 diabetes treatment effect heterogeneity and evaluate the potential for precision medicine to inform future clinical care.

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Contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Treatment effect heterogeneity following type 2 diabetes treatment with GLP1-receptor agonists and SGLT2-inhibitors: a systematic review
Date Crossref: 05/10/2023
Éditeur: Springer Science and Business Media LLC
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.

Institutions déclarées

University of Exeter Royal Devon and Exeter Hospital University of Dundee Genomics (United Kingdom)University of North Carolina at Chapel Hill Johns Hopkins University Johns Hopkins Medicine VA Eastern Colorado Health Care System University of Colorado Anschutz University of Colorado Denver Brigham and Women's Hospital Harvard University Exeter Hospital Exeter Hospital University of Copenhagen Novo Nordisk Foundation Massachusetts General Hospital Lund University University of Cambridge Rosie Hospital University of Calgary Madras Diabetes Research Foundation Cardinal Glennon Children’s Medical Center Saint Louis University Universitat Autònoma de Barcelona Instituto de Salud Carlos III Hospital de Sant Pau Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine Institut de Recerca Sant Pau Broad Institute Indiana University School of Medicine Indiana University – Purdue University Indianapolis Rutgers, The State University of New Jersey Centre Hospitalier Universitaire Sainte-Justine Université de Montréal Erasmus MC Stanford University University of Florida University of Helsinki Helsinki University Hospital Institute for Molecular Medicine Finland Folkhälsans Forskningscentrum Boston Children's Hospital Chinese University of Hong Kong University of Malaya Asia Diabetes Foundation Boston Children's Museum University of Eastern Finland Kuopio University Hospital The Queen's Medical Research Institute University of Edinburgh University of Pittsburgh University of Padua Zuyderland Medisch Centrum University of Chicago Deutsches Diabetes-Zentrum e.V.German Center for Diabetes Research Heinrich Heine University Düsseldorf Slovak Academy of Sciences Institute of Experimental Endocrinology of the Slovak Academy of Sciences University of Bergen Haukeland University Hospital Eastern Health Monash University Baylor College of Medicine Children's Nutrition Research Center at Baylor College of Medicine Texas Children's Hospital University of Manitoba Inserm Sorbonne Université Nutrition et obésité : approches systémiques Assistance Publique – Hôpitaux de Paris Dalian Medical University Second Affiliated Hospital of Chongqing Medical University Chongqing Medical University King's College London University of the Witwatersrand Riley Hospital for Children Richard L. Roudebush VA Medical Center Institut d'Investigació Biomèdica de Girona Hospital Universitari de Girona Doctor Josep Trueta Northwell Health Feinstein Institute for Medical Research University of California, San Francisco Cedars-Sinai Medical Center The University of Adelaide University of South Dakota Sanford Children's Specialty Clinic Colorado School of Public Health University of Oxford Oxford Centre for Diabetes, Endocrinology and Metabolism Children's Hospital of Pittsburgh Benaroya Research Institute Northwestern University Population Health Research Institute McMaster University University of KwaZulu-Natal University of Virginia University of Minnesota KU Leuven University of Glasgow University of Southern Denmark Rigshospitalet National Health Research Institutes Taipei Veterans General Hospital Taichung Veterans General Hospital Steno Diabetes Centers Aarhus University Hospital University Children's Hospital Tübingen Institute of Diabetes Research Newcastle University Joslin Diabetes Center University Medical Center Groningen Hôpital Saint-Antoine Centre de Recherche Saint-Antoine The Royal Melbourne Hospital The University of Melbourne Deakin University Walter and Eliza Hall Institute of Medical Research Guy's and St Thomas' NHS Foundation Trust Hôpital Necker-Enfants Malades Institut Cochin University of Maryland, Baltimore Dartmouth College Azienda USL di Bologna University of Bologna Pitié-Salpêtrière Hospital National University of Singapore Kaiser Permanente National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases Lurie Children's Hospital Impact American Diabetes Association University of Antwerp University of Gondar University of Colorado Boulder Trinity College Dublin Wexford General Hospital Endeavor Health Aarhus University Royal Devon & Exeter NHS Foundation Trust Sanford Research University of Washington Université de Sherbrooke Harvard Pilgrim Health Care Seoul National University Hospital Icahn School of Medicine at Mount Sinai Imperial College Healthcare NHS Trust Imperial College London Dr. Mohan's Diabetes Specialities Centre University of Auckland Counties Manukau District Health Board Auckland District Health Board Wellcome/MRC Institute of Metabolic Science Oxford BioMedica (United Kingdom)University of Michigan Translational Research Institute for Metabolism and Diabetes Pennington Biomedical Research Center Institute of Genetics and Cancer Yale University The University of Sydney Royal Prince Alfred Hospital Kaiser Permanente Center for Health Research Düsseldorf University Hospital

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Sujets associés

Diabetes Treatment and ManagementPancreatic function and diabetesDiabetes Management and Research

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