The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities
Rattachement africain : bd, Égypte. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Globally, prostate cancer (PCa) is regarded as a challenging health issue, and the number of PCa patients continues to rise despite the availability of effective treatments in recent decades. The current therapy with chemotherapeutic drugs has been largely ineffective due to multidrug resistance and the conventional treatment has restricted drug accessibility to malignant tissues, necessitating a higher dosage resulting in increased cytotoxicity. Plant-derived bioactive compounds have recently attracted a great deal of attention in the field of PCa treatment due to their potent effects on several molecular targets and synergistic effects with anti-PCa drugs. This review emphasizes the molecular mechanism of phytochemicals on PCa cells, the synergistic effects of compound-drug interactions, and stem cell targeting for PCa treatment. Some potential compounds, such as curcumin, phenethyl-isothiocyanate, fisetin, baicalein, berberine, lutein, and many others, exert an anti-PCa effect via inhibiting proliferation, metastasis, cell cycle progression, and normal apoptosis pathways. In addition, multiple studies have demonstrated that the isolated natural compounds: d-limonene, paeonol, lanreotide, artesunate, and bicalutamide have potential synergistic effects. Further, a significant number of natural compounds effectively target PCa stem cells. However, further high-quality studies are needed to firmly establish the clinical efficacy of these phytochemicals against PCa.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities
- Date Crossref
- 02/10/2023
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Rajshahi Department of Biochemistry and Molecular Biology pays non établi dans la noticeUniversité ou école supérieure
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Gopalganj Science and Technology University pays non établi dans la noticeUniversité ou école supérieure
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Chittagong Medical College Bachelor of Medicine and Surgery pays non établi dans la noticeÉtablissement de santé
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Ain Shams University Department of Pharmacognosy Cairo, Égypte (code pays fourni par la source)Université ou école supérieure
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Department of Biochemistry and Molecular Biology Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalgonj Bangladesh Department of Biochemistry and Molecular Biology pays non établi dans la noticeUniversité ou école supérieure
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Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalgonj Bangladesh pays non établi dans la noticeUniversité ou école supérieure
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Department of Genetic Engineering and Biotechnology Jashore University of Science and Technology (JUST) Jashore Bangladesh Department of Genetic Engineering and Biotechnology pays non établi dans la noticeUniversité ou école supérieure
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Department of Fisheries and Marine Bioscience Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalgonj Bangladesh pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Pharmacy Department of Pharmacognosy Cairo, Égypte (pays nommé en fin d’affiliation)Université ou école supérieure
Department of Biochemistry and Molecular Biology — University of Rajshahi, Gopalganj Science and Technology University et Bachelor of Medicine and Surgery — Chittagong Medical College, avec 6 autres affiliations. Pays d’affiliation : Égypte.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.