Primary Synovial Sarcoma of the Bone: A Case Report and Literature Review
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Le résumé fourni par la source
BACKGROUND/AIM: Synovial sarcoma (SS), a spindle cell sarcoma, typically occurs in the soft tissues of the extremities and rarely develops in the bones as a primary tumor. To our knowledge, no case of SS in the metacarpal bone has been reported. CASE REPORT: We report a case of primary SS of the metacarpal bone. Considering the clinical and imaging findings, SS was difficult to diagnose; therefore, we performed an open biopsy. Next, we performed a wide resection following the management guidelines for SS of the soft tissue. Immunohistochemistry (IHC) showed positive staining for SS18:SSX and SSX, and fluorescence in situ hybridization showed positive staining for the SS18 split. Owing to FNCLCC grade 3 tumor and the R1 margin, adjuvant chemotherapy with ifosfamide and doxorubicin was initiated. Finally, SS of the bone was diagnosed. Furthermore, we reviewed a total of 37 published cases of primary bone SS, including our case. Age and sex were almost the same in all cases of bone SS, and the most frequent site was the long bone in the lower extremity. CONCLUSION: IHC for SS18::SSX and SSX antibodies are beneficial for diagnosing general SS and SS of the bone. Moreover, SS of the bone should be considered in the differential diagnosis of spindle cell sarcomas of the bone. Wide resection and chemotherapy are recommended as current treatment strategies, although further studies are required regarding treatment validity.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Primary Synovial Sarcoma of the Bone: A Case Report and Literature Review
- Date Crossref
- 30/08/2023
- Éditeur
- International Institute of Anticancer Research
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Yamanashi pays non établi dans la noticeUniversité ou école supérieure
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Saitama International Medical Center pays non établi dans la noticeÉtablissement de santé
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Saitama Medical University Department of Pathology pays non établi dans la noticeUniversité ou école supérieure
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Social Insurance Saitama Chuo Hospital pays non établi dans la noticeÉtablissement de santé
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Interdisciplinary Graduate School of Medicine Department of Orthopedic Surgery pays non établi dans la noticeUniversité ou école supérieure
University of Yamanashi, Saitama International Medical Center et Department of Pathology — Saitama Medical University, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.