Advanced diffusion-weighted MRI and proteomic analysis as potential predictors of renal tumor histopathology

Le résumé fourni par la source

In this prospective, single-center study, we evaluated the use of intravoxel incoherent motion model of diffusion (IVIM-DWI) and high-throughput urine proteomics associated with inflammation for diagnosis and characterization of small renal masses. IVIM-DWI parameters had good to excellent diagnostic performance in identifying clear-cell renal cell carcinomas (ccRCC), as well as in distinguishing between stages of ccRCC. In a subset of patients with IVIM-DWI and proteomics, we observed significant correlations between IVIM and proteomic analytes which had differential expression between ccRCC and non-ccRCC, and are involved in promoting the recruitment, expansion and activation of innate and adaptive immune cells.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.