Accès ouvert déclaré
2023
article
HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis
Martin E. Baumdick, Annika Niehrs, Frauke Degenhardt, Maria Schwerk, Ole Hinrichs, Ana Jordan-Paiz, Benedetta Padoan, Lucy H.M. Wegner, Sebastian Schloer, Britta F. Zecher, Jakob Malsy, Vinita R. Joshi, Christin Illig, Jennifer Schröder‐Schwarz, Kimberly J. Möller, Felix Felix, Flomm, Markus Flosbach, Julia Jäger, Niklas Jeromin, Johannes M. Jung, Mareike Ohms, Konrad Reinshagen, Johann Rische, Adrian Sagebiel, Deborah Sandfort, Fenja Steinert, Christian Tomuschat, Jasmin Wesche, Maureen P. Martin, Yuko Yuki, Mikki Ozawa, Jürgen Sauter, Alexander H. Schmidt, Daniel Pérez, Anastasios D. Giannou, Mary Carrington, Randall S. Davis, Udo Schumacher, Guido Sauter, Samuel Huber, Victor G. Puelles, Nathaniel Melling, Shifteh Abedian, Clara Abraham, Jean–Paul Achkar, Tariq Ahmad, Rudi Alberts, Behrooz Z. Alizadeh, Leila Amininejad, Ashwin N. Ananthakrishnan, Vibeke Andersen, Carl A. Anderson, Jane M. Andrews, Vito Annese, Guy Aumais, Leonard Baidoo, Robert N. Baldassano, Peter A. Bampton, Murray L. Barclay, Jeffrey C. Barrett, Johannes Bethge, Claire Bewshea, Joshua C. Bis, Alain Bitton, B.K. Thelma, Gabrielle Boucher, Oliver Brain, Stephan Brand, Steven R. Brant, Jae Hee Cheon, Angela Chew, Judy H. Cho, Isabelle Cleynen, Ariella Cohain, Rachel Cooney, Anthony Croft, Mark J. Daly, Mauro D’Amato, Silvio Danese, Naser Ebrahim Daryani, Lisa W. Datta, Goda Denapienė, Lee A. Denson, Kathy L. Devaney, Olivier Dewit, R. D’Incà, Hazel E. Drummond, Marla Dubinsky, Richard H. Duerr, Cathryn Edwards, David Ellinghaus, Pierre Ellul, Motohiro Esaki, Jonah Essers, Lynnette Ferguson, Eleonora A. Festen, Philip Fleshner, Tim Florin, Denis Franchimont, Yuta Fuyuno, Richard B. Gearry, Michel Georges, Christian Gieger, Jürgen Glas, Philippe Goyette, Todd Green, Anne M. Griffiths, Stephen L. Guthery, Håkon Håkonarson, Jonas Halfvarson, Katherine Hanigan, Talin Haritunians, Ailsa Hart, C J Hawkey, Nicholas K. Hayward, Matija Hedl, Paul Henderson, Georgina L. Hold, Myhunghee Hong, Xinli Hu, Hailiang Huang, Jean‐Pierre Hugot, Ken Hui, Marcin Imieliński, Omid Jazayeri, Laimas Jonaitis, Luke Jostins, Garima Juyal, Ramesh C. Juyal, Rahul Kalla, Tom H. Karlsen, Nicholas A. Kennedy, Mohammed Azam Khan, Won Ho Kim, Takanari Kitazono, Gediminas Kiudelis, Michiaki Kubo, Subra Kugathasan, Limas Kupčinskas, Christopher A Lamb, Katrina M. de Lange, Anna Latiano, Debby Laukens, Ian C. Lawrance, James Lee, Charlie W. Lees, Mārcis Leja, Nina Lewis, Johan Van Limbergen, Paolo Lionetti, Jimmy Z. Liu, Edouard Louis, Yang Luo, Gillian Mahy, Masoud Malekzadeh, Reza Malekzadeh, John Mansfield, Suzie Marriott, Dunecan Massey, Christopher G. Mathew, Toshiyuki Matsui, Dermot McGovern, Vandana Midha, Raquel Milgrom, Samaneh Mirzaei, Mitja Mitrovič, Grant W. Montgomery, Craig Mowat, Christoph Müller, William G. Newman, Aylwin Ng, Siew C. Ng, Sok Meng Evelyn Ng, Susanna Nikolaus, Kaida Ning, Markus M. Nöthen, Ioannis Oikonomou, David T. Okou, Timothy R. Orchard, Orazio Palmieri, Miles Parkes, Anne Phillips, Cyriel Y. Ponsioen, Uroš Potočnik, Hossein Poustchi, Natalie J. Prescott, Deborah D. Proctor, Graham Radford-Smith, Jean‐François Rahier, Miguel Regueiro, Walter Reinisch, Florian Rieder, John D. Rioux, Rebecca L Roberts, Gerhard Rogler, Richard K. Russell, Jeremy Sanderson, Miquel Sans, Jack Satsangi, Eric E. Schadt, Michael Scharl, John Schembri, Stefan Schreiber, L. Philip Schumm, Regan L. Scott, Mark Seielstad, Tejas Shah, Yashoda Sharma, Mark S. Silverberg, Alison Simmons, Lisa A. Simms, Abhey Singh, Jurgita Skieceviciene, Suzanne van Sommeren, Kyuyoung Song, Ajit Sood, Sarah L. Spain, A. Hillary Steinhart, Joanne M. Stempak, Laura Stronati, Joseph J.�Y. Sung, Stephan R. Targan, Kirstin M. Taylor, Emilie Théâtre, Leif Törkvist, Esther A. Torres, Mark Tremelling, Holm H. Uhlig, Junji Umeno, Homayon Vahedi, Eric Vasiliauskas, Anje ter Velde, Nicholas T. Ventham, Séverine Vermeire, Hein W. Verspaget, Martine De Vos, Kai Wang, Ming‐Hsi Wang, Rinse K. Weersma, Zhi Wei, David C. Whiteman, Cisca Wijmenga, David C. Wilson, Juliane Winkelmann, Sunny H. Wong, Ramnik J. Xavier, Keiko Yamazaki, Suk‐Kyun Yang, Byong Duk Ye, Sebastian Zeißig, Bin Zhang, Hu Zhang, Hu Zhang, Wei Zhang, Hongyu Zhao, Zhen Zhao, Marcus Altfeld, Madeleine J. Bunders
21Citations signalées, ce qui n’est pas une note de qualité
16Institutions déclarées
4Pays d’affiliation déclarés
Rattachement africain : de, sk, us, dk.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background & Aims Ulcerative colitis (UC) is characterized by severe inflammation and destruction of the intestinal epithelium, and is associated with specific risk single nucleotide polymorphisms in HLA class II . Given the recently discovered interactions between subsets of HLA-DP molecules and the activating natural killer (NK) cell receptor NKp44, genetic associations of UC and HLA-DP haplotypes and their functional implications were investigated. Methods HLA-DP haplotype and UC risk association analyses were performed (UC: n = 13,927; control: n = 26,764). Expression levels of HLA-DP on intestinal epithelial cells (IECs) in individuals with and without UC were quantified. Human intestinal 3-dimensional (3D) organoid cocultures with human NK cells were used to determine functional consequences of interactions between HLA-DP and NKp44. Results These studies identified HLA-DPA1∗01:03-DPB1∗04:01 ( HLA-DP401 ) as a risk haplotype and HLA-DPA1∗01:03-DPB1∗03:01 ( HLA-DP301 ) as a protective haplotype for UC in European populations. HLA-DP expression was significantly higher on IECs of individuals with UC compared with controls. IECs in human intestinal 3D organoids derived from HLA-DP401 pos individuals showed significantly stronger binding of NKp44 compared with HLA-DP301 pos IECs. HLA-DP401 pos IECs in organoids triggered increased degranulation and tumor necrosis factor production by NKp44 + NK cells in cocultures, resulting in enhanced epithelial cell death compared with HLA-DP301 pos organoids. Blocking of HLA-DP401–NKp44 interactions (anti-NKp44) abrogated NK cell activity in cocultures. Conclusions We identified an UC risk HLA-DP haplotype that engages NKp44 and activates NKp44 + NK cells, mediating damage to intestinal epithelial cells in an HLA-DP haplotype–dependent manner. The molecular interaction between NKp44 and HLA-DP401 in UC can be targeted by therapeutic interventions to reduce NKp44 + NK cell–mediated destruction of the intestinal epithelium in UC.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis
- Date Crossref
- 01/10/2023
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Immune Cell Function and InteractionMicroscopic ColitisIL-33, ST2, and ILC Pathways