Environmental enrichment promotes adaptive responding during tests of behavioral regulation in male heterogeneous stock rats
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Le résumé fourni par la source
Organisms must regulate their behavior flexibly in the face of environmental challenges. Failure can lead to a host of maladaptive behavioral traits associated with a range of neuropsychiatric disorders, including attention deficit hyperactivity disorder, autism, and substance use disorders. This maladaptive dysregulation of behavior is influenced by genetic and environmental factors. For example, environmental enrichment produces beneficial neurobehavioral effects in animal models of such disorders. The present study determined the effects of environmental enrichment on a range of measures related to behavioral regulation using a large cohort of male, outbred heterogeneous stock (HS) rats as subjects to mimic the genetic variability found in the human population. Subjects were reared from late adolescence onwards either in pairs in standard housing with minimal enrichment (n=200) or in groups of 16 in a highly enriched environment consisting of a large multi-level cage filled with toys, running wheels, and shelters (n=64). Rats were subjected to a battery of tests, including: (i) locomotor response to novelty, (iI) light reinforcement, (iii) social reinforcement, (iv) reaction time, (v) a patch-depletion foraging test, (vi) Pavlovian conditioned approach, (vii) conditioned reinforcement, and (viii) cocaine conditioned cue preference. Results indicated that rats housed in the enriched environment were able to filter out irrelevant stimuli more effectively and thereby regulate their behavior more efficiently than standard-housing rats. The dramatic impact of environmental enrichment suggests that behavioral studies using standard housing conditions may not generalize to more complex environments that may be more ethologically relevant.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Environmental enrichment promotes adaptive responding during tests of behavioral regulation in male heterogeneous stock rats
- Date Crossref
- 03/07/2023
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University at Buffalo Clinical and Research Institute on Addictions pays non établi dans la noticeUniversité ou école supérieure
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University of California San Diego Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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Wake Forest University pays non établi dans la noticeUniversité ou école supérieure
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California State University Department of Psychology pays non établi dans la noticeUniversité ou école supérieure
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Oregon Health & Science University Department of Behavioral Neuroscience pays non établi dans la noticeUniversité ou école supérieure
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Wake Forest School of Medicine Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
Clinical and Research Institute on Addictions — University at Buffalo, Department of Psychiatry — University of California San Diego et Wake Forest University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.