Anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh
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Le résumé fourni par la source
INTRODUCTION: Arsenic methylation converts inorganic arsenic (iAs) to monomethyl (MMA) and dimethyl (DMA) arsenic compounds. Body mass index (BMI) has been positively associated with arsenic methylation efficiency (higher DMA%) in adults, but evidence in pregnancy is inconsistent. We estimated associations between anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh. METHODS: We enrolled pregnant women (n = 784) (median [IQR] gestational week: 14 [13, 15]) in Gaibandha District, Bangladesh from 2018 to 2019. Anthropometric measures were BMI, subscapular and triceps skinfold thicknesses, and mid-upper arm circumference (MUAC), fat area (MUAFA), and muscle area (MUAMA). Arsenic methylation measures were urinary iAs, MMA, and DMA divided by their sum and multiplied by 100 (iAs%, MMA%, and DMA%), primary methylation index (MMA/iAs; PMI), and secondary methylation index (DMA/MMA; SMI). In complete cases (n = 765 [97.6%]), we fitted linear, beta, and Dirichlet regression models to estimate cross-sectional differences in iAs%, MMA%, DMA%, PMI, and SMI per IQR-unit difference in each anthropometric measure, adjusting for drinking water arsenic, age, gestational age, education, living standards index, and plasma folate, vitamin B12, and homocysteine. RESULTS: , respectively. Median (IQR) iAs%, MMA%, DMA%, PMI, and SMI were 12.0 (9.3, 15.2)%, 6.6 (5.3, 8.3)%, 81.0 (77.1, 84.6)%, 0.6 (0.4, 0.7), and 12.2 (9.3, 15.7), respectively. In both unadjusted and adjusted linear models, all anthropometric measures were negatively associated with iAs%, MMA%, and PMI and positively associated with DMA% and SMI. For example, fully adjusted mean differences (95% CI) in DMA% per IQR-unit difference in BMI, subscapular skinfolds thickness, triceps skinfold thickness, MUAC, MUAFA, and MUAMA were 1.72 (1.16, 2.28), 1.58 (0.95, 2.21), 1.74 (1.11, 2.37), 1.45 (0.85, 2.06), 1.70 (1.08, 2.31), and 0.70 (0.13, 1.27) pp, respectively. CONCLUSIONS: Anthropometric measures were positively associated with arsenic methylation efficiency among pregnant women in the early second trimester.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh
- Date Crossref
- 01/10/2023
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Johns Hopkins University pays non établi dans la noticeUniversité ou école supérieure
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Columbia University Department of Environmental Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of North Carolina at Chapel Hill Department of Environmental Sciences & Engineering pays non établi dans la noticeUniversité ou école supérieure
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University of Graz Institute of Chemistry - Analytical Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Lamont-Doherty Earth Observatory pays non établi dans la noticeStructure de recherche
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Child Health Research Foundation pays non établi dans la noticeOrganisation à but non lucratif
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Johns Hopkins Bloomberg School of Public Health Department of Environmental Health & Engineering pays non établi dans la noticeUniversité ou école supérieure
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JiVitA Maternal and Child Health and Nutrition Research Project pays non établi dans la noticeInstitution
Johns Hopkins University, Department of Environmental Health Sciences — Columbia University et Department of Environmental Sciences & Engineering — University of North Carolina at Chapel Hill, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.