The role of h-FABP and Myoglobin in Determining Disease Severity and Prognosis in STEMI
Rattachement africain : kh, tr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Introduction: Acute coronary syndrome (ACS) remains as a single biggest cause of death worldwide.Heart-type fatty acid -binding protein (h-FABP) and myoglobin are small proteins present in the myocyte cytosol.In cases of myocardial damage, they can freely pass into the bloodstream.Thus, they might be useful in the diagnosis of ACS.The aim of this prospective study was to search the relationship between h-FABP and myoglobin levels and disease severity and mortality.Methods: One hundred-fourty-nine male patients with ST-elevation myocardial infarction consitututed our study population.Two groups occurred according to low (<23) and high (≥23) SYNTAX score as group 1 and group 2. Blood specimens were taken for h-FABP and myoglobin analysis at hospital admission and at 12 h.Patients underwent coronary angiography for diagnosis and treatment, and the SYNTAX score was calculated.Participants were followed up for 72 months, and cardiovascular mortality rates were recorded.Results: H-FABP at admission and h-FABP level at 12 th h were lower in group 1 than in group 2 (p<0.001).We did not find significant differences between the myoglobin levels measured at the time of hospital entrance and at the 12 th h in both groups.During 72-month follow-up, 123 patients survived and the survivors had a lower SYNTAX score, and a lower h-FABP level at admission.In the univariate analysi, h-FABP levels at admission and at 12 h were found to be independent predictors of coronary artery disease (CAD) severity.However, h-FABP levels did not predict mortality.Conclusion: In patients with ACS, measuring h-FABP levels at admission and in the late period (12 th hour) are helpful, not only in the diagnosis but also severity and seriousness of CAD.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The role of h-FABP and Myoglobin in Determining Disease Severity and Prognosis in STEMI
- Date Crossref
- 31/05/2023
- Éditeur
- Galenos Yayinevi
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Health Science pays non établi dans la noticeUniversité ou école supérieure
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Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi pays non établi dans la noticeÉtablissement de santé
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Sağlık Bilimleri Üniversitesi pays non établi dans la noticeUniversité ou école supérieure
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Burdur Mehmet Akif Ersoy Üniversitesi pays non établi dans la noticeUniversité ou école supérieure
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Istanbul Eye Hospital pays non établi dans la noticeÉtablissement de santé
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İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi pays non établi dans la noticeÉtablissement de santé
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Göztepe Prof. Dr. Süleyman Yalçın City Hospital pays non établi dans la noticeÉtablissement de santé
University of Health Science, Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi et Sağlık Bilimleri Üniversitesi, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.