Current Principles, Challenges, and New Metrics in pH-Responsive Drug Delivery Systems for Systemic Cancer Therapy
Rattachement africain : ru. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The paradigm of drug delivery via particulate formulations is one of the leading ideas that enable overcoming limitations of traditional chemotherapeutic agents. The trend toward more complex multifunctional drug carriers is well-traced in the literature. Nowadays, the prospectiveness of stimuli-responsive systems capable of controlled cargo release in the lesion nidus is widely accepted. Both endogenous and exogenous stimuli are employed for this purpose; however, endogenous pH is the most common trigger. Unfortunately, scientists encounter multiple challenges on the way to the implementation of this idea related to the vehicles' accumulation in off-target tissues, their immunogenicity, the complexity of drug delivery to intracellular targets, and finally, the difficulties in the fabrication of carriers matching all imposed requirements. Here, we discuss fundamental strategies for pH-responsive drug delivery, as well as limitations related to such carriers' application, and reveal the main problems, weaknesses, and reasons for poor clinical results. Moreover, we attempted to formulate the profiles of an "ideal" drug carrier in the frame of different strategies drawing on the example of metal-comprising materials and considered recently published studies through the lens of these profiles. We believe that this approach will facilitate the formulation of the main challenges facing researchers and the identification of the most promising trends in technology development.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Current Principles, Challenges, and New Metrics in pH-Responsive Drug Delivery Systems for Systemic Cancer Therapy
- Date Crossref
- 22/05/2023
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Saratov State University Science Medical Center pays non établi dans la noticeUniversité ou école supérieure
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Ministry of Health of the Russian Federation pays non établi dans la noticeOrganisme public
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Saratov State Medical University Central Research Laboratory pays non établi dans la noticeUniversité ou école supérieure
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Sechenov University pays non établi dans la noticeUniversité ou école supérieure
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N. I. Lobachevsky State University of Nizhny Novgorod Institute of Biology and Biomedicine pays non établi dans la noticeUniversité ou école supérieure
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I. M. Sechenov First Moscow State Medical University Institute of Molecular Theranostics pays non établi dans la noticeUniversité ou école supérieure
Science Medical Center — Saratov State University, Ministry of Health of the Russian Federation et Central Research Laboratory — Saratov State Medical University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.