Accès ouvert déclaré
2023
article
Risk of Midlife Stroke After Adverse Pregnancy Outcomes: The FinnGen Study
Eliza C. Miller, Anni Kauko, Sarah E. Tom, Hannele M. Laivuori, Teemu Niiranen, Natalie Ann Bello, Aarno V. Palotie, Mark J. Daly, Bridget Riley-Gills, Howard J. Jacob, Dirk S. Paul, Athena Matakidou, Adam Platt, Heiko Runz, Sally John, George Okafo, Nathan M. Lawless, Heli Salminen‐Mankonen, Robert M. Plenge, Joseph Maranville, Mark I. McCarthy, Julie Hunkapiller, Margaret G. Ehm, Kirsi Auro, Simonne Longerich, Caroline S. Fox, Anders Mälarstig, Katherine Wood Klinger, Deepak Raipal, Eric P Green, Robert Graham, Robert Yang, Chris O ́Donnell, Tomi P. Mäkelä, Jaakko A. Kaprio, Petri Virolainen, Antti Hakanen, Terhi M Kilpi, Markus Perola, Jukka Partanen, Anne Pitkäranta, Taneli Raivio, Raisa Serpi, Tarja Laitinen, Veli‐Matti Kosma, Jari A. Laukkanen, Marco Hautalahti, Outi Tuovila, Raimo Pakkanen, Jeffrey F. Waring, Bridget M. Riley-Gillis, Fedik Rahimov, Ioanna Tachmazidou, Chia-Yen Chen, Zhihao Ding, Marc Jung, Shameek Biswas, Rion K. Pendergrass, David J. Pulford, Neha S. Raghavan, Adriana Huertas‐Vázquez, Jae-Hoon Sul, Xinli Hu, Sahar V. Mozaffari, Dawn M. Waterworth, Nicole Renaud, Ma ́en Obeidat, Samuli Ripatti, Johanna Schleutker, Mikko Arvas, Olli Carpén, Reetta Hinttala, Johannes Kettunen, Katriina Aalto‐Setälä, Mika A. P. Kähönen, Johanna Mäkelä, Reetta K. Kälviäinen, Valtteri Julkunen, Hilkka S. Soininen, Anne Marja Remes, Mikko O. Hiltunen, Jukka Peltola, Minna Raivio, Pentti J. Tienari, Juha O. Rinne, Roosa Kallionpää, Juulia Partanen, Ali Abbasi, Adam E. Ziemann, Nizar Smaoui, Anne Lehtonen, Susan Eaton, Sanni Lahdenperä, Natalie Bowers, Edmond Teng, Fanli Xu, Laura Addis, John D. Eicher, Qingqin S. Li, Karen Y. He, Ekaterina A. Khramtsova, Martti A. Färkkilä, Jukka T. Koskela, Sampsa Pikkarainen, Airi Jussila, Katri Kaukinen, Timo Blomster, MIKKO S. KIVINIEMI, Markku Voutilainen, Tim Y. -T. Lu, Linda C. McCarthy, Amy B. Hart, Meijian Guan, Jason Miller, Kirsi Kalpala, Melissa R. Miller, Kari K. Eklund, Antti Palomäki, Pia Isomäki, Laura Pirilä, Oili Kaipiainen‐Seppänen, Johanna A. Huhtakangas, Nina Mars, Apinya Lertratanakul, Marla Hochfeld, Jorge Esparza Gordillo, Fabiana de Andrade Farias, Nan Bing, Margit K. Pelkonen, Hannu Kankaanranta, Terttu H. Harju, Riitta Lahesmaa, Glenda Lassi, Hubert Chen, Joanna C. Betts, Rajashree Mishra, Majd Mouded, Debby Ngo, Felix C. Vaura, Veikko V Salomaa, Kaj Metsärinne, Jenni Aittokallio, Jussi A. Hernesniemi, Daniel Gordin, Juha P. Sinisalo, Marja‐Riitta Taskinen, Timo P. Hiltunen, Amanda Elliott, Mary Pat Reeve, Sanni Ruotsalainen, Benjamin Challis, Audrey Y. Chu, Dermot F. Reilly, Mike Mendelson, Jaakko Parkkinen, Tuomo J Meretoja, Heikki Joensuu, Johanna Mattson, Eveliina Salminen, Annika Auranen, Peeter Karihtala, Päivi Auvinen Klaus Elenius, Esa Pitkänen, Relja Popovic, Jennifer L. Schutzman, Diptee A. Kulkarni, Alessandro Porello, Andrey P. Loboda, Heli J. Lehtonen, Stefan I. McDonough, Sauli Vuoti, Kai Kaarniranta, Joni A. Turunen, Terhi Ollila, Hannu M T Uusitalo, Juha M Karjalainen, Mengzhen Liu, Stephanie J. Loomis, Erich C. Strauss, Hao Chen, Kaisa Tasanen, Laura Huilaja, Katariina Hannula‐Jouppi, Teea T. Salmi, Sirkku A. Peltonen, Leena M. Koulu, David F. Choy, Ying Wu, Pirkko J. Pussinen, Aino Salminen, Tuula Anneli Salo, David P. C. Rice, Pekka Nieminen, Ulla Palotie, Maria Siponen, Liisa Suominen, Päivi Mäntylä, Ulvi Kahraman Gürsoy, Vuokko Anttonen, Kirsi Sipilä, Venla Kurra, Laura Kotaniemi‐Talonen, Oskari Heikinheimo, Ilkka E. J. Kalliala, Lauri A. Aaltonen, Varpu Jokimaa, Marja Vääräsmäki, Outi Uimari, Laure C. Morin-Papunen, Maarit J. Niinimäki, Terhi Piltonen, Katja Kivinen, Elisabeth Widén, Taru Tukiainen, Mark Daly, Niko Välimäki, Eija K. Laakkonen, Jaakko S. Tyrmi, Heidi Silven, Eeva Sliz, Riikka K. Arffman, Susanna M. Savukoski, Triin Laisk, Natalia Pujol, Janet Kumar, Iiris Hovatta, Erkki Tapio Isometsä, Hanna Maria Ollila, Jaana Suvisaari, Thomas D. Als, Antti A. Mäkitie, Argyro J. Bizaki-Vallaskangas, Sanna Katriina Toppila-Salmi, Tytti Willberg, Elmo Saarentaus, Antti A. Aarnisalo, Elisa Rahikkala, Kristiina Aittomäki, Fredrik O. Åberg, Mitja Kurki, Aki Samuli Havulinna, Juha Mehtonen, Priit Palta, Shabbeer Hassan, Pietro Della, Briotta Parolo, Wei Zhou, Mutaamba Maasha, Susanna M. Lemmelä, Manuel A. Rivas, Mari Niemi, Aoxing Liu, Arto Lehistö, Andrea Ganna, Vincent Llorens, Henrike Heyne, Joel T Rämö, Rodos Rodosthenous, Satu J. Strausz, Tuula Palotie, Kimmo Palin, Javier Gracia‐Tabuenca, Harri Siirtola, Tuomo Kiiskinen, Jiwoo Lee, Kristin Tsuo, Kati Kristiansson, Kati Hyvärinen, Jarmo Ritari, Katri Pylkäs, Minna K. Karjalainen, Tuomo Mantere, Eeva Kangasniemi, Sami Heikkinen, Nina Pitkänen, Samuel Lessard, Clément Chatelain, Perttu Terho, Sirpa Soini, Eero Punkka, Sanna Siltanen, Teijo Kuopio, Anu Jalanko, Huei-Yi Shen, Risto Kajanne, Mervi Aavikko, Henna Palin, Malla-Maria Linna, Masahiro Kanai, L. Elisa Lahtela, Mari Anneli Kaunisto, Elina Kilpeläinen, Timo Petteri Sipila, Oluwaseun Alexander Dada, Awaisa Ghazal, Anastasia Kytölä, Rigbe G. Weldatsadik, Kati M. Donner, Anu Loukola, Päivi Laiho, Tuuli Sistonen, Essi Kaiharju, Markku Laukkanen, Elina Järvensivu, Sini Lähteenmäki, Lotta Männikkö, Regis Wong, Auli Toivola, Minna Brunfeldt, Hannele Mattsson, Sami Koskelainen, Tero Hiekkalinna, Teemu I. Paajanen, Kalle Pärn, Mart Kals, Shuang Luo, Shanmukha Sampath Padmanabhuni, Marianna Niemi, Mika Helminen, Tiina Hannele Luukkaala, Iida Vähätalo, Jyrki Pitkänen, Sarah Smith, Tom Southerington
29Citations signalées, ce qui n’est pas une note de qualité
8Institutions déclarées
2Pays d’affiliation déclarés
Rattachement africain : us, fi.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Adverse pregnancy outcomes (APO) contribute to higher risk of maternal cerebrovascular disease, but longitudinal data that include APO and stroke timing are lacking. We hypothesized that APO are associated with younger age at first stroke, with a stronger relationship in those with >1 pregnancy with APO. METHODS: We analyzed longitudinal Finnish nationwide health registry data from the FinnGen Study. We included women who gave birth after 1969 when the hospital discharge registry was established. We defined APO as a pregnancy affected by gestational hypertension, preeclampsia, eclampsia, preterm birth, small for gestational age infant, or placental abruption. We defined stroke as first hospital admission for ischemic stroke or nontraumatic intracerebral or subarachnoid hemorrhage, excluding stroke during pregnancy or within 1 year postpartum. We used Kaplan-Meier survival curves and multivariable-adjusted Cox and generalized linear models to assess the relationship between APO and future stroke. RESULTS: We included 144 306 women with a total of 316 789 births in the analysis sample, of whom 17.9% had at least 1 pregnancy with an APO and 2.9% experienced an APO in ≥2 pregnancies. Women with APO had more comorbidities including obesity, hypertension, heart disease, and migraine. Median age at first stroke was 58.3 years in those with no APO, 54.8 years in those with 1 APO, and 51.6 years in those with recurrent APO. In models adjusted for sociodemographic characteristics and stroke risk factors, risk of stroke was greater in women with 1 APO (adjusted hazard ratio, 1.3 [95% CI, 1.2-1.4]) and recurrent APO (adjusted hazard ratio, 1.4 [95% CI, 1.2-1.7]) compared with those with no APO. Women with recurrent APO had more than twice the stroke risk before age 45 (adjusted odds ratio, 2.1 [95% CI, 1.5-3.1]) compared with those without APO. CONCLUSIONS: Women who experience APO have earlier onset of cerebrovascular disease, with the earliest onset in those with more than 1 affected pregnancy.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Risk of Midlife Stroke After Adverse Pregnancy Outcomes: The FinnGen Study
- Date Crossref
- 01/07/2023
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Columbia University
Department of Neurology
pays non établi dans la notice
Université ou école supérieure
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University of Turku
Department of Internal Medicine
pays non établi dans la notice
Université ou école supérieure
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Turku University of Applied Sciences
pays non établi dans la notice
Université ou école supérieure
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Tampere University Hospital
and Maternal Health Research
pays non établi dans la notice
Établissement de santé
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Tampere University
pays non établi dans la notice
Université ou école supérieure
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Institute for Molecular Medicine Finland
pays non établi dans la notice
Structure de recherche
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Finnish Institute for Health and Welfare
Department of Health
pays non établi dans la notice
Organisme public
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Cedars-Sinai Medical Center
Department of Cardiology
pays non établi dans la notice
Établissement de santé
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University of Helsinki
Institute for Molecular Medicine Finland
pays non établi dans la notice
Université ou école supérieure
Department of Neurology — Columbia University, Department of Internal Medicine — University of Turku et Turku University of Applied Sciences, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Neurological Complications and SyndromesPregnancy and preeclampsia studiesCardiovascular Issues in Pregnancy