Resting-state MRI functional connectivity as a neural correlate of multidomain lifestyle adherence in older adults at risk for Alzheimer’s disease
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Le résumé fourni par la source
Prior research has demonstrated the importance of a healthy lifestyle to protect brain health and diminish dementia risk in later life. While a multidomain lifestyle provides an ecological perspective to voluntary engagement, its association with brain health is still under-investigated. Therefore, understanding the neural mechanisms underlying multidomain lifestyle engagement, particularly in older adults at risk for Alzheimer's disease (AD), gives valuable insights into providing lifestyle advice and intervention for those in need. The current study included 139 healthy older adults with familial risk for AD from the Prevent-AD longitudinal aging cohort. Self-reported exercise engagement, cognitive activity engagement, healthy diet adherence, and social activity engagement were included to examine potential phenotypes of an individual's lifestyle adherence. Two adherence profiles were discovered using data-driven clustering methodology [i.e., Adherence to healthy lifestyle (AL) group and Non-adherence to healthy lifestyle group]. Resting-state functional connectivity matrices and grey matter brain features obtained from magnetic resonance imaging were used to classify the two groups using a support vector machine (SVM). The SVM classifier was 75% accurate in separating groups. The features that show consistently high importance to the classification model were functional connectivity mainly between nodes located in different prior-defined functional networks. Most nodes were located in the default mode network, dorsal attention network, and visual network. Our results provide preliminary evidence of neurobiological characteristics underlying multidomain healthy lifestyle choices.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Resting-state MRI functional connectivity as a neural correlate of multidomain lifestyle adherence in older adults at risk for Alzheimer’s disease
- Date Crossref
- 09/05/2023
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Northeastern University Department of Psychology pays non établi dans la noticeUniversité ou école supérieure
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McGill University Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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Douglas Mental Health University Institute pays non établi dans la noticeÉtablissement de santé
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Alzheimer Society of Canada pays non établi dans la noticeOrganisation à but non lucratif
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University of Illinois Urbana-Champaign pays non établi dans la noticeUniversité ou école supérieure
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Montreal Neurological Institute and Hospital pays non établi dans la noticeÉtablissement de santé
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Southern States University pays non établi dans la noticeUniversité ou école supérieure
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Université de Montréal pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins University pays non établi dans la noticeUniversité ou école supérieure
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Wake Forest University pays non établi dans la noticeUniversité ou école supérieure
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Washington University in St. Louis pays non établi dans la noticeUniversité ou école supérieure
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Alzheimer's Association pays non établi dans la noticeOrganisation à but non lucratif
Department of Psychology — Northeastern University, Department of Psychiatry — McGill University et Douglas Mental Health University Institute, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.