Fabiola Ferdinand

Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity

Alexis Moscoso, Fiona Heeman, Sheelakumari Raghavan, Alejandro Costoya‐Sánchez et autres

Importance: Tau positron emission tomography (PET) allows in vivo detection of neurofibrillary tangles, a core neuropathologic feature of Alzheimer disease (AD). Objective: To provide estimates of the frequency of tau PET positivity and its associated risk of clinical outcomes. Design, Setting, and …

es, se, us, ch, kr, nl, br, de, ca, gb (code pays fourni par la source)

Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease

Christina Tremblay, Shady Rahayel, Alexandre Pastor‐Bernier, Frédéric St‐Onge et autres

Alzheimer's disease is associated with pre-symptomatic changes in brain morphometry and accumulation of abnormal tau and amyloid-beta pathology. Studying the development of brain changes prior to symptoms onset may lead to early diagnostic biomarkers and a better understanding of Alzheimer's disease pathophysiology. …

ca (code pays fourni par la source)

Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson’s disease

Alex I. Wiesman, Victoria Madge, Edward A. Fon, Alain Dagher et autres

Parkinson's disease (PD) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (SN) and the locus coeruleus (LC), respectively, resulting in motor and cognitive impairments. Although SN dopamine dysfunction has clear neurophysiological effects, the association of …

ca (code pays fourni par la source)

Neurobehavioral Mechanisms Influencing the Association Between Generativity, the Desire to Promote Well-Being of Younger Generations, and Purpose in Life in Older Adults at Risk for Alzheimer’s Disease

Caitlin S. Walker, LINDA C. LI, Giulia Baracchini, Jennifer Tremblay‐Mercier et autres

OBJECTIVES: Generativity, the desire and action to improve the well-being of younger generations, is associated with purpose in life among older adults. However, the neurobehavioral factors supporting the relationship between generativity and purpose in life remain unknown. This study aims to identify …

ca, us (code pays fourni par la source)

Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains

Marc James Quesnel, Anne Labonté, Cynthia Picard, Henrik Zetterberg et autres

Insulin, insulin-like growth factors (IGF) and their receptors are highly expressed in the adult hippocampus. Thus, disturbances in the insulin-IGF signalling pathway may account for the selective vulnerability of the hippocampus to nascent Alzheimer's disease (AD) pathology. In the present study, we …

ca, us, se, gb, cn, fr (code pays fourni par la source)

Resting-state MRI functional connectivity as a neural correlate of multidomain lifestyle adherence in older adults at risk for Alzheimer’s disease

Meishan Ai, Timothy P. Morris, Jiahe Zhang, Adrián Noriega de la Colina et autres

Prior research has demonstrated the importance of a healthy lifestyle to protect brain health and diminish dementia risk in later life. While a multidomain lifestyle provides an ecological perspective to voluntary engagement, its association with brain health is still under-investigated. Therefore, understanding …

us, ca (code pays fourni par la source)

Assessment of white matter hyperintensity severity using multimodal magnetic resonance imaging

Olivier Parent, Aurélie Bussy, Gabriel A. Devenyi, Alyssa Dai et autres

Abstract White matter hyperintensities are radiological abnormalities reflecting cerebrovascular dysfunction detectable using MRI. White matter hyperintensities are often present in individuals at the later stages of the lifespan and in prodromal stages in the Alzheimer’s disease spectrum. Tissue alterations underlying white matter …

ca (code pays fourni par la source)

Spatial Extent of Amyloid-β Levels and Associations With Tau-PET and Cognition

Hazal Ozlen, Alexa Pichet Binette, Theresa Köbe, Pierre‐François Meyer et autres

Importance: Preventive trials of anti-amyloid agents might preferably recruit persons showing earliest biologically relevant β-amyloid (Aβ) binding on positron emission tomography (PET). Objective: To investigate the timing at which Aβ-PET binding starts showing associations with other markers of Alzheimer disease. Design, Setting, …

ca, us (code pays fourni par la source)

Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment

Cherie Strikwerda‐Brown, Diana A. Hobbs, Julie Gonneaud, Frédéric St‐Onge et autres

Importance: National Institute on Aging-Alzheimer's Association (NIA-AA) workgroups have proposed biological research criteria intended to identify individuals with preclinical Alzheimer disease (AD). Objective: To assess the clinical value of these biological criteria to identify older individuals without cognitive impairment who are at …

ca, us, fr, se, au (code pays fourni par la source)

Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer’s Disease

Alexa Pichet Binette, Étienne Vachon‐Presseau, John C. Morris, Randall John Bateman et autres

BACKGROUND: Major prevention trials for Alzheimer's disease (AD) are now focusing on multidomain lifestyle interventions. However, the exact combination of behavioral factors related to AD pathology remains unclear. In 2 cohorts of cognitively unimpaired individuals at risk of AD, we examined which …

ca, us (code pays fourni par la source)

Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer’s Disease

Sander C.J. Verfaillie, Alexa Pichet Binette, Étienne Vachon‐Presseau, Shirin Tabrizi et autres

ca, nl, us (code pays fourni par la source)

P4‐310: The Effect of Lumbar Puncture on the Retention of the Prevent‐ad Cohort ad

Pedro Rosa‐Neto, Tharick Ali Pascoal, Joanne Frenette, Jennifer Tremblay‐Mercier et autres

In preventive clinical trials, cerebrospinal fluid (CSF) provides valuable means for enriching populations, ascertaining target engagements as well as a measuring the efficacy of drug interventions. However, retention constitutes a challenge given the adverse effects associated with longitudinal lumbar punctures (LP). Here …

ca (code pays fourni par la source)